Relative Bioavailability and Pharmacokinetic Parameters Following Adminstration of Single Oral Dose (2×150 mg) of Chloroquine Tablet in Healthy Subjects

1995 ◽  
Vol 21 (20) ◽  
pp. 2393-2402 ◽  
Author(s):  
H. Tajecadeh ◽  
M. R. Rouini ◽  
A. Gharecolchian
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Relative Bioavailability ◽  
Pharmacokinetic Parameters

scholarly journals Sparfloxacin Distribution in Human Saliva

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Kolaci M ◽  
Deda L
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Human Saliva

Aim: The aim of this study is to assess the penetration of sparfloxacin in mixed human saliva after a single oral dose of 400mg in Caucasian healthy subjects.

Absorption; metabolism and excretion of a single oral dose of 14c-paliperidone 1mg in healthy subjects (PAL-053)

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
M Vermeir ◽  
S Boom ◽  
I Naessens ◽  
K Talluri ◽  
M Eerdekens ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects

scholarly journals Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers.

2001 ◽  
Vol 27 (4) ◽  
pp. 375-379
Author(s):  
Masahiko Obayashi ◽  
Yoshiaki Matsumoto ◽  
Kayoko Hashimoto ◽  
Takayoshi Kosugi ◽  
Minoru Kurokawa ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Volunteers ◽  
Single Oral Dose ◽  
Pharmacokinetic Parameters

Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects

2020 ◽  
Vol 85 (5) ◽  
pp. 899-906 ◽  
Author(s):  
Ken Ogasawara ◽  
Christine Xu ◽  
Vanaja Kanamaluru ◽  
Maria Palmisano ◽  
Gopal Krishna
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Oral Doses

scholarly journals Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Wirin Limopasmanee ◽  
Sunee Chansakaow ◽  
Noppamas Rojanasthien ◽  
Maleeya Manorot ◽  
Chaichan Sangdee ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Postmenopausal Women ◽  
Pharmacokinetic Parameters ◽  
Soy Milk ◽  
Open Label ◽  
Fixed Sequence ◽  
Time Curve ◽  
Oral Doses

A combination of soy isoflavones andLiu Wei Di Huang Wan(LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed withβ-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentrationCmax, time to reach peak concentrationTmax, area under the plasma concentration-time curve (AUC), and half-life (t1/2). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens.

Effects of Cloprednol and other Corticosteroids on Hypothalamic-Pituitary-Adrenal Axis Function

1976 ◽  
Vol 4 (5) ◽  
pp. 326-337 ◽  
Author(s):  
Eduardo Ortega ◽  
Consuelo Rodriguez ◽  
L James Strand ◽  
Eugene Segre
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Hpa Axis ◽  
Healthy Subjects ◽  
Plasma Cortisol ◽  
Cortisol Response ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Hpa Function

The effects of cloprednol and other synthetic corticosteroids on hypothalamic-pituitary-adrenal (HPA) function were studied in healthy subjects after administration of a single oral dose of corticosteroid at 6 a.m. or 6 p.m., and after daily 6 a.m. administration of corticosteroids at various doses for seven days. The degree of HPA suppression was assessed by metyrapone tests (METP), insulin hypoglycaemia tests (IHT) and 6 a.m. fasting plasma Cortisol concentrations. Regardless of the corticosteroid tested, 6 p.m. dosing was at least four-fold more suppressive of METP response than 6 a.m. administration. At therapeutically equivalent doses, single doses of triamcinolone and dexamethasone were more suppressive of HPA-axis function than cloprednol, hydrocortisone or prednisolone. After 6 a.m. administration for seven days, 12·5 mg of cloprednol did not impair the Cortisol response to IHT or interfere with the METP response. The clinically equivalent dose of prednisolone (25 mg) resulted in slightly greater HPA-axis suppression. All doses of dexamethasone (0·5, 3·75 and 6·0 mg) and of betamethasone (2·0, 4·0 and 6·5 mg) were more suppressive of HPA-axis function than either cloprednol or prednisolone. These results suggest that at equipotent anti-inflammatory doses, cloprednol is slightly less suppressive of HPA-axis function than prednisolone, and both cloprednol and prednisolone are much less suppressive than dexamethasone or betamethasone.

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