Effect of Lactic Acid Content into on during Miconazole Eye Drops to be Used for Infection Preventive

Purpose: The aims of this study were to prepare a 0.1% Miconazole (MCZ) eye-drop solution and to evaluate the stability and physical properties of the preparation.

Safety Evaluations of Topical Vitamin K1 for Epidermal Growth Factor Receptor Inhibitor-Induced Rash

Papulopustular rash occurs in 80% of patients receiving Epidermal Growth Factor Receptor Inhibitor therapy for cancer. Topical vitamin K1, a phosphatase inhibitor, could reduce epidermal growth factor receptor inhibitor-induced rash. This preliminary safety study evaluated a novel topical 0.1% vitamin K1product for potential use in patients with epidermal growth factor receptor inhibitor-induced rash. Ten healthy subjects applied topical 0.1% vitamin K1 to healthy and tape stripped skin every 12 hours for five doses. Vitamin K1 levels were measured by ELISA in serum and plasma at 0, 26, and 50 hours. Vitamin K1 levels ranged between 0 to 8.22ng/ml. Bivariate correlative analyses showed no association between mean vitamin K1 concentration and time (r=0.008, p=0.930). Using a range of vitamin K1 concentrations (2.5 to 100ng/ml) that encompassed and exceeded the levels detected in our healthy subjects, we evaluated the ability of vitamin K1 to reverse cetixumab-induced Epidermal Growth Factor Receptor inhibition in A549 lung cancer cells. Vitamin K1 did not significantly change phosphorylated-Epidermal Growth Factor Receptor levels in cetuximab-treated cells (p>0.670). In conclusion, systemic vitamin K1 levels up to 100ng/ml would not interfere with epidermal growth factor receptor inhibitor therapy. Our next step is to test the effectiveness of our 0.1% topical VK1 formulation for Epidermal Growth Factor Receptor Inhibitor-induced rash in patients receiving epidermal growth factor receptor inhibitor therapy in a randomized, placebo-controlled, blinded study.

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation and Cancer in Real World: Meta-Analysis of Retrospective Observational Studies

Background: Evidence on the safety and effectiveness of Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) in Atrial Fibrillation (AF) patients with cancer is rather limited, so we performed this meta-analysis to compare the efficacy and safety of NOACs with vitamin K antagonists (VKAs) in real-world patients with AF and cancer.

Observational Follow-Up Study of Hospitalized Patients Diagnosed with COVID-19 to Evaluate the Effectiveness of the Pharmacological Treatment Used to Treat this Disease. COVID-19 Registry

Background: During the early months of the pandemic (between March and April 2020), a pragmatic, non-commercial clinical investigation was conducted to recognize the clinical status and severity of patients hospitalized with COVID-19, in accordance with available treatments authorized by regulatory agencies.

SARS Cov2 in Children

It is a general viral disease, which means that it can be transmitted from animal to human and vice versa, and this indicates that it is a virus that transcends different races and types of living organisms.

Erectile Dysfunction and Premature Ejaculation Drugs: Mode of Action and Analytical Methods Literature Review

This literature review focuses on drugs used for erectile dysfunction and premature ejaculation, in respect of mode of action and different analytical techniques used for their determination either alone or in combination with other drugs in different pharmaceutical and biological matrices. The cited drugs are Sildenafil, Avanafil, Apomormphine, Yohimbine, Tramadol, Dapoxetine, and Trazodone.

Investigation of Dry Granulation and Wet Granulation Effect on Dissolution Profile of the Developed Film Coated Tablets Containing Eplerenone

The objective is to observe and improve drug release of Eplerenone which is BCS Class II API by applying dry granulation and wet granulation process. Inspra 50 mg film coated tablets, manufactured by Pfizer, were taken as reference product to compare with dissolution profiles of dry granulation applied product and wet granulation applied product. Investigation of the effect of wet granulation process on dissolution profiles of Eplerenone 50 mg film coated tablets has been demonstrated out in the scope the study. While f2 similarity factor is 44.93 for dry granulation applied product, it is 60.62 for wet granulation applied product when compared to reference product. It comply that dissolution rate of wet granulation applied product is more proper to the specification than dry granulation applied product. The study demonstrates the effect of different granulation process on dissolution rate.

Genetic Effects of Ultra-High-Diluted-Biomedicines Gall 30C, Gall 200C, and Gall 1000C may be Vaccines against Plant and COVID-19 Diseases: Improved Agriculture-Health-Medical-Pharmaceutical-ScienceTechnology-Communication-Issues!

The current coronavirus 2 (SARS-CoV-2) outbreaks of Coronavirus disease 2019 (COVID-19) pandemic have emphasized the vulnerability of human populations to novel viral pressures, causing an emergent global pandemic and badly impacts on agriculture-environment-health-socio-economy medical-pharmaceutical-science-technology-communication-issues. And India emphasis on okra, Abelmoschus esculentus (L.) Moench Cv. Ankur-40, the ‘Nature’s-Gift to Human-Disease-Free-Healthy-Life’ and the most ‘Economically-Important Number-One Consumption-Vegetable-Crops,’ is damaged by different pathogens like nematodes, causing the root-knot (RK) disease which is easily controlled by different chemical-pesticides, and so it is an urgent need to develop potential epidemiological and biomedical vaccines. The Ultra-High-Diluted Biomedicines (UHDBM) Gall 30C, Gall 200C, and Gall 100C, prepared from Okra Root-Galls (ORG) or Gall MT, applied by foliar spray @ 20 mL/plant each group respectively, are highly effective against the root-knot disease of okra, with increasing fresh-plant growth and fruit production. The UHDBM; Gall 30C, Gall 200C, and Gall 1000-pretreatments are more effective than the untreated ones, and Gall 200C shows the most potential result in all respects. The genetic-effects of UHDBM thought to induce systemic acquired resistance response of the treated plants through the expression of pathogenesis-related (PR)- proteins-genes (22 to 4 numbers), which are more or less similar molecular range (295 kD to 11 kD) of many coronaviruses, and it will responsible for preventing RK and COVID-19 like variant-virus diseases by inducing defense-resistance or increasing innate-immunity, and enriching agricultureenvironment-health-socio-economy-medical-pharmaceutical-science-technology-communication-issues (AEHSEMPSTCI) with the toxic-free world, and it may help to develop best potential new preventive treatments methods or drug or vaccines, in the field of ‘21st Century COVID-19 like Pandemic in the new normal situation in future.

Sparfloxacin Distribution in Human Saliva

Aim: The aim of this study is to assess the penetration of sparfloxacin in mixed human saliva after a single oral dose of 400mg in Caucasian healthy subjects.