Percutaneous Absorption of LHRH Through Porcine Skin: Effect of N-Methyl 2-Pyrrolidone and Isopropyl Myristate

1997 ◽  
Vol 23 (11) ◽  
pp. 1111-1114 ◽  
Author(s):  
K. S. Bhatia ◽  
J. Singh
Keyword(s):  
Percutaneous Absorption ◽  
Skin Effect ◽  
Isopropyl Myristate ◽  
Porcine Skin

scholarly journals Preparation, Characterisation, and Topical Delivery of Terbinafine

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 548 ◽  
Author(s):  
A. S. M. Monjur Al Hossain ◽  
Bruno C. Sil ◽  
Fotis Iliopoulos ◽  
Rebecca Lever ◽  
Jonathan Hadgraft ◽  
...  
Keyword(s):  
Propylene Glycol ◽  
Fungal Infections ◽  
Isopropyl Myristate ◽  
Limited Information ◽  
Free Base ◽  
Porcine Skin ◽  
Salt Form ◽  
Scanning Calorimetry ◽  
Polyethylene Glycol 200

Terbinafine (TBF) is commonly used in the management of fungal infections of the skin because of its broad spectrum of activity. Currently, formulations containing the free base and salt form are available. However, there is only limited information in the literature about the physicochemical properties of this drug and its uptake by the skin. In this work, we conducted a comprehensive characterisation of TBF, and we also examined its percutaneous absorption in vitro in porcine skin. TBF-free base was synthesised from the hydrochloride salt by a simple proton displacement reaction. Both the free base and salt form were further analysed using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). Delivery of TBF-free base in excised porcine skin was investigated from the following solvents: Isopropyl myristate (IPM), propylene glycol monolaurate (PGML), Transcutol® (TC), propylene glycol (PG), polyethylene glycol 200 (PEG 200), oleic acid (OL), ethanol (EtOH), and isopropyl alcohol (IPA). Permeation and mass balance studies confirmed that PG and TC were the most efficacious vehicles, delivering higher amounts of TBF-free base to the skin compared with a commercial gel (p < 0.05). These preliminary results are promising and will inform the development of more complex formulations in future work.

Parathion metabolism during percutaneous absorption in perfused porcine skin

1990 ◽  
Vol 38 (3) ◽  
pp. 245-254 ◽  
Author(s):  
Michael P. Carver ◽  
Patricia E. Levi ◽  
J.Edmond Riviere
Keyword(s):  
Percutaneous Absorption ◽  
Porcine Skin

Evaluation of Quantum Dot Skin Penetration in Porcine Skin: Effect of Age and Anatomical Site of Topical Application

2019 ◽  
Vol 32 (4) ◽  
pp. 182-191 ◽  
Author(s):  
Christofori M.R.R. Nastiti ◽  
Yousuf Mohammed ◽  
Krishna C. Telaprolu ◽  
Xiaowen Liang ◽  
Jeffrey E. Grice ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Topical Application ◽  
Skin Effect ◽  
Skin Penetration ◽  
Anatomical Site ◽  
Porcine Skin ◽  
Effect Of Age
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