Staining tumor cells with biotinylated ACL-I, a lectin isolated from the marine sponge, Axinella corrugata

2012 ◽  
Vol 88 (1) ◽  
pp. 1-9 ◽  
Author(s):  
RR Dresch ◽  
GD Zanetti ◽  
FJ Irazoqui ◽  
VG Sendra ◽  
N Zlocowski ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Marine Sponge ◽  
Axinella Corrugata

scholarly journals Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110337
Author(s):  
Shu-Yen Fang ◽  
Sheng-Yuan Chen ◽  
You-Ying Chen ◽  
Tsu-Jen Kuo ◽  
Zhi-Hong Wen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Marine Sponge ◽  
Biosynthetic Pathway ◽  
Spectroscopic Methods

A new natural indole, vibrindole B (1), together with known analogs, vibrindole A (2), trisindoline (3), norharmane (4), and 3-(hydroxyacetyl)indole (5), produced by the bacterium Pseudovibrio denitrificans P81, were isolated from a sponge, Aaptos species. The structures of indoles 1 to 5 were established by spectroscopic methods. The proposed biosynthetic pathway of 1 to 5 is also discussed, starting from tryptophan. Moreover, indoles 1 to 3 were found to exhibit cytotoxicity toward T24 tumor cells with IC50 values of 1.71 ± 0.11, 4.53 ± 0.14, and 2.26 ± 0.26 µM, respectively.

scholarly journals Compounds from the marine sponge Cribrochalina vasculum offer a way to target IGF-1R mediated signaling in tumor cells

Oncotarget ◽  
2016 ◽  
Vol 7 (31) ◽  
pp. 50258-50276 ◽  
Author(s):  
Ana Zovko ◽  
Metka Novak ◽  
Petra Hååg ◽  
Dimitry Kovalerchick ◽  
Teresa Holmlund ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Marine Sponge

Immunohistochemical localization of an N-acetyl amino-carbohydrate specific lectin (ACL-I) of the marine sponge Axinella corrugata

2011 ◽  
Vol 113 (6) ◽  
pp. 671-674 ◽  
Author(s):  
Roger Remy Dresch ◽  
Gilberto Dolejal Zanetti ◽  
João Henrique Corrêa Kanan ◽  
Beatriz Mothes ◽  
Cléa Beatriz Lerner ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Immunohistochemical Localization ◽  
Axinella Corrugata

Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.

Tetrahedron ◽  
2004 ◽  
Vol 60 (33) ◽  
pp. 7053-7059 ◽  
Author(s):  
Shunji Aoki ◽  
Liwei Cao ◽  
Kouhei Matsui ◽  
Rachmaniar Rachmat ◽  
Shin-ichi Akiyama ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Marine Sponge ◽  
P Glycoprotein

scholarly journals Neopetrosiamides, Peptides from the Marine Sponge Neopetrosia sp. that Inhibit Amoeboid Invasion by Human Tumor Cells.

ChemInform ◽  
2006 ◽  
Vol 37 (1) ◽  
Author(s):  
David E. Williams ◽  
Pamela Austin ◽  
Ana R. Diaz-Marrero ◽  
Rob Van Soest ◽  
Teatulohi Matainaho ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Marine Sponge ◽  
Human Tumor ◽  
Human Tumor Cells

scholarly journals Gracilosulfates A–G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 454
Author(s):  
Larisa K. Shubina ◽  
Tatyana N. Makarieva ◽  
Vladimir A. Denisenko ◽  
Roman S. Popov ◽  
Sergey A. Dyshlovoy ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Tumor Cells ◽  
Marine Sponge ◽  
Specific Antigen ◽  
Structural Motif ◽  
Structural Group

Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A–G (1–7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structures were determined by NMR and MS methods. The compounds 1, 2, 4, 6, and 7 inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.

Development of a red-shifted fluorescence-based assay for SARS-coronavirus 3CL protease: identification of a novel class of anti-SARS agents from the tropical marine sponge Axinella corrugata

2006 ◽  
Vol 387 (8) ◽  
pp. 1063-1074 ◽  
Author(s):  
Pamela Hamill ◽  
Derek Hudson ◽  
Richard Y. Kao ◽  
Polly Chow ◽  
Meera Raj ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Acid Ethyl Ester ◽  
Coumarin Derivative ◽  
Sars Coronavirus ◽  
Acceptor Pair ◽  
Donor And Acceptor ◽  
Axinella Corrugata ◽  
Black Hole Quencher

Abstract SARS-coronavirus (SARS-CoV) encodes a main protease, 3CLpro, which plays an essential role in the viral life cycle and is currently the prime target for discovering new anti-coronavirus agents. In this article, we report our success in developing a novel red-shifted (RS) fluorescence-based assay for 3CLpro and its application for identifying small-molecule anti-SARS agents from marine organisms. We have synthesised and characterised the first generation of a red-shifted internally quenched fluorogenic substrate (RS-IQFS) for 3CLpro based on resonance energy transfer between the donor and acceptor pair CAL Fluor Red 610 and Black Hole Quencher-1 (K m and k cat values of 14 μM and 0.65 min-1). The RS-IQFS primary sequence was selected based on the results of our screening analysis of 3CLpro performed using a series of blue-shifted (BS)-IQFSs corresponding to the 3CLpro-mediated cleavage junctions of the SARS-CoV polyproteins. In contrast to BS-IQFSs, the RS-IQFS was not susceptible to fluorescence interference from coloured samples and allowed for successful screening of marine natural products and identification of a coumarin derivative, esculetin-4-carboxylic acid ethyl ester, a novel 3CLpro inhibitor (IC50=46 μM) and anti-SARS agent (EC50=112 μM; median toxic concentration >800 μM) from the tropical marine sponge Axinella corrugata.

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