Location of Tumour Cells in Colon Tissue by Texas Red Labelled Pentosan Polysulphate, an Inhibitor of a Cell Surface Protease

1996 ◽  
Vol 10 (3) ◽  
pp. 203-214 ◽  
Author(s):  
M. Anees
Keyword(s):  
Cell Surface ◽  
Tumour Cells ◽  
Colon Tissue ◽  
A Cell ◽  
Pentosan Polysulphate ◽  
Texas Red ◽  
Cell Surface Protease

Labelling of Tumour Cells with a Biotinylated Inhibitor of a Cell Surface Protease

1991 ◽  
Vol 4 (4) ◽  
pp. 337-346 ◽  
Author(s):  
F. S. Steven ◽  
M. M. Griffin ◽  
L. A. Williams ◽  
N. W. Clarke ◽  
H. Maier
Keyword(s):  
Cell Surface ◽  
Tumour Cells ◽  
A Cell ◽  
Cell Surface Protease

scholarly journals Involvement of Domain 3 in Oligomerization by the Protective Antigen Moiety of Anthrax Toxin

2001 ◽  
Vol 183 (6) ◽  
pp. 2111-2116 ◽  
Author(s):  
Jeremy Mogridge ◽  
Michael Mourez ◽  
R. John Collier
Keyword(s):  
Cell Surface ◽  
Mammalian Cells ◽  
Protective Antigen ◽  
Anthrax Toxin ◽  
Membrane Insertion ◽  
A Cell ◽  
Domain 3 ◽  
Active Fragment ◽  
Cell Surface Protease ◽  
Pa Domain

ABSTRACT Protective antigen (PA), a component of anthrax toxin, binds receptors on mammalian cells and is activated by a cell surface protease. The resulting active fragment, PA63, forms ring-shaped heptamers, binds the enzymic moieties of the toxin, and translocates them to the cytosol. Of the four crystallographic domains of PA, domain 1 has been implicated in binding the enzymic moieties; domain 2 is involved in membrane insertion and oligomerization; and domain 4 binds receptor. To determine the function of domain 3, we developed a screen that allowed us to isolate random mutations that cause defects in the activity of PA. We identified several mutations in domain 3 that affect monomer-monomer interactions in the PA63 heptamer, indicating that this may be the primary function of this domain.

Inhibition of a Cell Surface Protease After Cisplatin Chemotherapy

1991 ◽  
Vol 5 (2) ◽  
pp. 151-164
Author(s):  
F. S. Steven ◽  
J. Zoeller ◽  
H. Maier ◽  
I. A. Born
Keyword(s):  
Cell Surface ◽  
A Cell ◽  
Cell Surface Protease

Fluorescent Inhibitors of a Cell Surface Protease Used to Locate Leukaemia Cells in Kidney Sections

1987 ◽  
Vol 1 (3) ◽  
pp. 203-213 ◽  
Author(s):  
F. S. Steven ◽  
M. M. Griffin ◽  
T. L. H. Wong ◽  
H. Jackson ◽  
F. Barnett
Keyword(s):  
Cell Surface ◽  
A Cell ◽  
Cell Surface Protease

Affinity Preparation of a Protein Inhibitor Recognising a Cell Surface Protease

1993 ◽  
Vol 7 (1) ◽  
pp. 65-76 ◽  
Author(s):  
F. S. Steven ◽  
Mm. Griffin ◽  
J. Bell ◽  
I. C. Talbot
Keyword(s):  
Cell Surface ◽  
Protein Inhibitor ◽  
A Cell ◽  
Cell Surface Protease
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