Understanding the availability, prevalence of use, desired effects, acute toxicity and dependence potential of the novel opioid MT-45

2014 ◽  
Vol 53 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Sindhu Siddiqi ◽  
Charlotte Verney ◽  
Paul Dargan ◽  
David M. Wood
Keyword(s):  
Acute Toxicity ◽  
The Novel ◽  
Dependence Potential

scholarly journals Acute toxicity studies of an novel natural polymer vigna mungo in swiss albino rats

2021 ◽  
Vol 12 (1) ◽  
pp. 947-953
Author(s):  
Krishnaveni Manubolu ◽  
Sreenivasulu Munna ◽  
Chandrasekhar Kothapalli Bonnoth
Keyword(s):  
Acute Toxicity ◽  
Test Group ◽  
Pharmaceutical Formulations ◽  
Vigna Mungo ◽  
Albino Rats ◽  
The Novel ◽  
Natural Polymer ◽  
Toxicity Studies ◽  
Solvent Extraction Method ◽  
Histopathological Studies

The aim of the present research is to investigate acute toxicity profiling of isolated Vigna mungo new natural polymer. Safety administration is the primitive criterion for any drug substance. To explore the safety and toxicity profiling of the novel polymer, this study was carried out. Vigna mungo novel polymer was isolated from the pulverised seeds of Vigna mungo which is part and parcel of our diet. This polymer is obtained using a non-solvent extraction method using acetone. Acute toxicity studies were performed according to the OECD guidelines 420. In this, the selected animal model is Swiss albino rats, grouped into control and test containing each three animals. 2000 mg/kg of Vigna mungo polymer was administered to a test group and did not produced any abnormalities and behavioural changes. Furthermore, histopathological studies, body weight, haematological parameters did not presented abnormal values. The observations found 2000mg/kg of a dose of the polymer did not cause lethality and death of any animal till 14 days of a period. It was concluded that Vigna mungo novel polymer is safe to administer up to 2000mg/kg dose. Hence, the novel Vigna mungo polymer is safer for therapeutic use in pharmaceutical formulations.

Preclinical Acute Toxicity Studies and Dosimetry Estimates of the Novel Sigma-1 Receptor Radiotracer, [18F]SFE

2006 ◽  
Vol 8 (5) ◽  
pp. 284-291 ◽  
Author(s):  
Rikki N. Waterhouse ◽  
Jun Zhao ◽  
Michael G. Stabin ◽  
Hanna Ng ◽  
Janice Schindler-Horvat ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
The Novel ◽  
Sigma 1 Receptor ◽  
Toxicity Studies ◽  
Sigma 1

Acute Toxicity Associated With the Recreational Use of the Novel Psychoactive Benzofuran N -methyl-5-(2 aminopropyl)benzofuran

2017 ◽  
Vol 69 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Katharina E. Hofer ◽  
Katrin Faber ◽  
Daniel M. Müller ◽  
Till Hauffe ◽  
Urs Wenger ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
The Novel ◽  
Recreational Use

scholarly journals Acute toxicity associated with the recreational use of the novel dissociative psychoactive substance methoxphenidine

2014 ◽  
Vol 52 (10) ◽  
pp. 1288-1291 ◽  
Author(s):  
Katharina E. Hofer ◽  
Colette Degrandi ◽  
Daniel M. Müller ◽  
Ursina Zürrer-Härdi ◽  
Schirin Wahl ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
The Novel ◽  
Psychoactive Substance ◽  
Recreational Use

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo

2004 ◽  
Vol 22 (4) ◽  
pp. 411-420 ◽  
Author(s):  
Joachim Gullbo ◽  
Elin Lindhagen ◽  
Saadia Bashir-Hassan ◽  
Marcus Tullberg ◽  
Hans Ehrsson ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Ethyl Ester ◽  
Antitumor Efficacy ◽  
The Novel

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
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