Skin Sensitization Potential of Polyethylene Glycols Evaluated in the Guinea Pig Maximization Test and the Human Repeat Insult Patch Test

1998 ◽  
Vol 17 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Hon-Wing Leung ◽  
Bryan Ballantyne
Keyword(s):  
Guinea Pig ◽  
Patch Test ◽  
Polyethylene Glycols ◽  
Skin Sensitization

Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization

1981 ◽  
Author(s):  
J. R. Horton ◽  
J. D. MacEwen ◽  
E. H. Vernot ◽  
A. Hall
Keyword(s):  
Guinea Pig ◽  
Skin Sensitization

Joint Positive Control Testing in Guinea Pig Skin Sensitization Tests

2002 ◽  
Vol 35 (1) ◽  
pp. 14-22 ◽  
Author(s):  
C. Wiemann ◽  
K. Berthold ◽  
A. Heusener ◽  
N. Krüger ◽  
A. Seeberger ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Positive Control ◽  
Skin Sensitization ◽  
Pig Skin

scholarly journals Sensitizing Capacities and Cross-Reactivity Patterns of Some Diisocyanates and Amines Using the Guinea-Pig Maximization Test. Can p-phenylenediamine be Used as a Marker for Diisocyanate Contact Allergy?

2017 ◽  
Vol 11 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Haneen Hamada ◽  
Erik Zimerson ◽  
Magnus Bruze ◽  
Marléne Isaksson ◽  
Malin Engfeldt
Keyword(s):  
Guinea Pig ◽  
Patch Test ◽  
Guinea Pigs ◽  
Contact Allergy ◽  
Cross Reactivity ◽  
The Other ◽  
Positive Patch Test ◽  
Other Hand ◽  
Test Reactions ◽  
Toxic Reactions

Background:Isocyanates are mainly considered respiratory allergens but can also cause contact allergy. Diphenylmethane-4,4′-diamine (4,4′-MDA) has been considered a marker for diphenylmethane-4,4′-diisocyanate (4,4′-MDI) contact allergy. Furthermore, overrepresentation of positive patch-test reactions top-phenylenediamine (PPD) in 4,4′-MDA positive patients have been reported.Objectives:To investigate the sensitizing capacities of toluene-2,4-diisocyanate (2,4-TDI) and PPD and the cross-reactivity of 4,4′-MDA, 2,4-TDI, dicyclohexylmethane-4,4′-diamine (4,4′-DMDA), dicyclohexylmethane-4,4′-diisocyanate (4,4′-DMDI), 4,4′-MDI and PPD.Methods:The Guinea Pig Maximization Test (GPMT) was used.Results:PPD was shown to be a strong sensitizer (p<0.001). Animals sensitized to PPD showed cross-reactivity to 4,4′-MDA (p<0.001). Animals sensitized to 4,4′-MDA did not show cross-reactivity to PPD. 8 animals sensitized to 2,4-TDI were sacrificed due to toxic reactions at the induction site and could thus not be fully evaluated.Conclusion:PPD was shown to be a strong sensitizer. However, it cannot be used as a marker for isocyanate contact allergy. On the other hand, positive reactions to 4,4′-MDA could indicate a PPD allergy. The intradermal induction concentration of 2,4-TDI (0.70% w/v) can induce strong local toxic reactions in guinea-pigs and should be lowered.

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