Diphoterine® Chemical Splash Decontamination Solution: Skin Sensitization Study in the Guinea Pig

2007 ◽  
Vol 26 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Laurence Mathieu ◽  
François Burgher ◽  
Alan H. Hall
Keyword(s):  
Guinea Pig ◽  
Skin Sensitization ◽  
Decontamination Solution

Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization

1981 ◽  
Author(s):  
J. R. Horton ◽  
J. D. MacEwen ◽  
E. H. Vernot ◽  
A. Hall
Keyword(s):  
Guinea Pig ◽  
Skin Sensitization

Joint Positive Control Testing in Guinea Pig Skin Sensitization Tests

2002 ◽  
Vol 35 (1) ◽  
pp. 14-22 ◽  
Author(s):  
C. Wiemann ◽  
K. Berthold ◽  
A. Heusener ◽  
N. Krüger ◽  
A. Seeberger ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Positive Control ◽  
Skin Sensitization ◽  
Pig Skin

Evaluating the safety and toxicity of a modified dextran-based biopolymer as a hemostat

2020 ◽  
Vol 09 ◽  
Author(s):  
Narges Maleksabet ◽  
Mohammadreza Masoumian ◽  
Asieh Aramvash
Keyword(s):  
Guinea Pig ◽  
Skin Irritation ◽  
Skin Sensitization ◽  
Efficacy And Safety ◽  
Safety And Efficacy ◽  
Hemostatic Agents ◽  
Crystal Violet Assay ◽  
Safety And Toxicity ◽  
Guinea Pig Model ◽  
Qualitative Estimation

Background: As an effective alternative to conventional suture techniques, topical hemostatic agents are widely used to control bleeding and close wounds in surgeries. Objective: This study was conducted to evaluate the efficacy and safety of a novel hydrogel hemostat that is easy to use in applicator under normal conditions according to ISO 10993. Methods: Safety of DexGel, a natural surgical hemostat containing mainly dextran that is an effective hydrogel in bleeding stop, was evaluated and compared to that of AristaTM. APTT test and cytotoxicity tests (i.e., MTT assay, Crystal violet assay, and qualitative estimation) were carried out for considering safety in skin sensitization in a guinea pig model. Results: This study has shown, DexGel does not cause any noticeable sensitization such as edema and erythema or observable toxicity for skin and does not disturb the coagulation process. In addition, cytotoxicity results approve its safety for cell survival. Conclusion: It can be concluded that the safety and efficacy of DexGel (5 g) are comparable or even better to that of AristaTM, which is commercial and frequently used hemostat and the lack of skin irritation and toxicity for DexGel, alleviates initial safety concerns for products based on these polymers and oligomers.

Final Report on the Safety Assessment of Cetearyl Octanoate

1982 ◽  
Vol 1 (4) ◽  
pp. 81-90 ◽  
Keyword(s):  
Guinea Pig ◽  
Clinical Studies ◽  
Safety Assessment ◽  
Final Report ◽  
Skin Sensitization ◽  
Eye Irritation ◽  
Available Information

Cetearyl Octanoate is the esterification product of 2-ethylhexanoic acid and cetearyl alcohol. The acute oral LD50 for Cetearyl Octanoate is estimated from studies with rats to be greater than 8.0 ml/kg. The ingredient produced no significant acute, subchronic or dermal skin or eye irritation when tested in rabbits. The ingredient produced no evidence of skin sensitization in the guinea pig. Similar studies with product formulations containing Cetearyl Octanoate confirmed these results, as well as indicated the ingredient was not phototoxic. In clinical studies, four of 100 subjects showed slight to moderate irritation with undiluted Cetearyl Octanoate. Product formulations containing between 0.2% and 30% Cetearyl Octanoate were tested on a total of 644 subjects with no signs of skin sensitization, photocontact allergenicity, or phototoxicity. From the available information, it is concluded that Cetearyl Octanoate is safe as a cosmetic ingredient in the present practices of use.

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