Second-trimester ultrasound screening of fetal anomalies

ABSTRACT In the last 20 years, the role of first-trimester ultrasound screening has expanded from individual calculation of the risk of aneuploidy through measurement of the nuchal translucency to a powerful technique to evaluate important aspects of the fetal anatomy. Traditionally, the full anatomy scan for detection of structural anomalies has been performed in the second trimester of pregnancy. However, with the implementation of the first-trimester scan at 11 to 13 weeks of gestation many of the structural anomalies traditionally detected in the second trimester can now be identified earlier in pregnancy. In the first part of this review we discuss the main ultrasound findings that may facilitate the prenatal detection of fetal brain, face and neck abnormalities in the first trimester of pregnancy. How to cite this article Sepulveda W, Illescas T, Adiego B, Martinez-Ten P. Prenatal Detection of Fetal Anomalies at the 11- to 13-Week Scan—Part I: Brain, Face and Neck. Donald School J Ultrasound Obstet Gynecol 2013;7(4):359-368.

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Second trimester ultrasound screening performed by midwives; sensitivity for detection of fetal anomalies

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1034/j.1600-0412.1999.780205.x ◽

1999 ◽

Vol 78 (2) ◽

pp. 98-104 ◽

Cited By ~ 3

Author(s):

Karin Eurenius ◽

Ove Axelsson ◽

Sven Cnattingius ◽

Lars Eriksson ◽

Torgny Norsted

Keyword(s):

Ultrasound Screening ◽

Second Trimester ◽

Fetal Anomalies

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Comparison of first and second trimester ultrasound screening for fetal anomalies in the southeast region of Sweden

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.3109/00016349.2010.517307 ◽

2010 ◽

Vol 89 (11) ◽

pp. 1412-1419 ◽

Cited By ~ 24

Author(s):

Eric Hildebrand ◽

Anders Selbing ◽

Marie Blomberg

Keyword(s):

Ultrasound Screening ◽

Second Trimester ◽

Fetal Anomalies ◽

Southeast Region

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Prenatal Biochemical and Ultrasound Markers in COVID-19 Pregnant Patients: A Prospective Case-Control Study

Diagnostics ◽

10.3390/diagnostics11030398 ◽

2021 ◽

Vol 11 (3) ◽

pp. 398

Author(s):

Stefano Cosma ◽

Andrea Roberto Carosso ◽

Fulvio Borella ◽

Jessica Cusato ◽

Marialuisa Bovetti ◽

...

Keyword(s):

Protein A ◽

Prenatal Testing ◽

First Trimester ◽

Negative Control ◽

Control Group ◽

Case Group ◽

Ultrasound Screening ◽

Second Trimester ◽

Fetal Anomalies ◽

First Trimester Of Pregnancy

This prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls (p = 0.77, 0.63, 0.30, 0.40, 0.28) or in the fetal incidence of structural anomalies at the second-trimester fetal anatomy scan (p = 0.21). No pneumonia or hospital admission due to COVID-19-related symptoms were observed. Asymptomatic or mildly symptomatic SARS-CoV-2 infection during the first trimester of pregnancy did not predispose affected women to more fetal anomalies than unaffected women. COVID-19 had a favorable maternal course at the beginning of pregnancy in our healthy cohort.

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