scholarly journals Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure

2021 ◽  
pp. 43-47
Author(s):  
S. S. Dunaevskaya ◽  
A. A. Kosik ◽  
A. N. Narkevich
Keyword(s):  
Surgical Treatment ◽  
Liver Resection ◽  
Liver Failure ◽  
Hepatic Failure ◽  
Primary Liver Cancer ◽  
Liver Parenchyma ◽  
Plasma Homocysteine ◽  
Class B ◽  
Focal Liver Disease ◽  
Benign Liver

This study aims to evaluate the level of plasma homocysteine in patients with acute post-resection hepatic failure, depending on the degree of the disease. Materials and Methods. The article presents the results of a study of plasma homocysteine levels in 40 patients with c different classes of acute post-resection liver failure. Indications for liver resection were: primary liver cancer 11 (27%), metastatic liver lesions 21 (53%), parasitic liver diseases 3 (7%), benign liver formations 5 (13%). Patients were divided into 3 groups - Patients with Post hepatectomy liver failure (PHLF) class developed in the postoperative period A, B and C. Results. Analysis of the data showed that the initially normal level of plasma homocysteine before liver resection (surgical treatment) and after has different developmental options. Depending on the class of post-resection hepatic failure, the level of plasma homocysteine changes and has deviations from the reference values. In a comparative analysis of the average homocysteine values in the group of patients with post-resection hepatic insufficiency of class A, after surgical treatment, they were significantly lower than in patients with PHLF B and C. In particular, in patients with class B and C PNF, there is a significant trend towards an increase in homocysteine levels after surgery. Hyperhomocysteinemia may be a risk factor for the development of acute liver failure after surgical treatment for focal liver disease. Possibly, its adverse effect on the function and restoration of the liver parenchyma, which requires further targeted study.

scholarly journals Hemoperitoneum After Spontaneous Rupture of Liver Tumor: Results of Surgical Treatment

HPB Surgery ◽  
1988 ◽  
Vol 1 (1) ◽  
pp. 81-83 ◽  
Author(s):  
Roland Andersson ◽  
Karl-Göran Tranberg ◽  
Stig Bengmark
Keyword(s):  
Surgical Treatment ◽  
Liver Resection ◽  
Spontaneous Rupture ◽  
Liver Tumors ◽  
Primary Liver Cancer ◽  
Liver Cyst ◽  
Liver Malignancy ◽  
Suture Ligation ◽  
Initial Symptoms ◽  
Operative Delay

Five cases of massive hemoperitoneum caused by spontaneous rupture of liver tumors, collected during a 27-year period, are reported. Four patients had a primary liver malignancy and one patient a liver cyst with hemangioma. Initial symptoms were obscure and hemoperitoneum was suspected pre-operatively in only one patient. At operation, a mean of 3100 ml of blood was found in the abdomen. Hemostatis was achieved by liver resection in four patients and by suture ligation in one. Two patients died during or shortly after operation. The three patients surviving the operation had primary liver cancer and lived for 6 months to 6.5 years. It is concluded that liver resection, whenever possible, is the treatment of choice and that pre-operative delay and mortality may be diminished by increased awareness of this condition.

Eight years after introducing liver resection at the Oncology Institute of Vojvodina

2013 ◽  
Vol 21 (3-4) ◽  
pp. 101-104
Author(s):  
Ivan Majdevac ◽  
Nikola Budisin ◽  
Milan Ranisavljevic ◽  
Dejan Lukic ◽  
Imre Lovas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Resection ◽  
Liver Tumors ◽  
Liver Parenchyma ◽  
Malignant Neoplasms ◽  
Chemotherapy Treatment ◽  
Primary Liver Tumors ◽  
Cancer Metastases ◽  
Colorectal Cancer Metastases ◽  
Medical Histories

Background: Hepatectomies are mostly performed for the treatment of hepatic benign or malignant neoplasms, intrahepatic gallstones, or parasitic cysts of the liver. The most common malignant neoplasms of the liver are metastases from colorectal cancer. Anatomic liver resection involves two or more hepatic segments, while non-anatomic liver resection involves resection of the metastases with a margin of uninvolved tissue. The aim of this manuscript was to show results of hepatectomies performed at the Oncology Institute of Vojvodina. Methods: We performed 133 liver resections from January 1997 to December 2013. Clinical and histopathological data were obtained from operative protocols, histopathological reports, and patients? medical histories. Results: We did 80 metastasectomies, 51 segmentectomies, and 18 radiofrequent ablations (RFA). Average number of colorectal cancer metastases was 1.67 per patient. We also made 10 left hepatectomies. In all cases, we made non-anatomic resections. Conclusion: Decision about anatomic versus non-anatomic resections for colorectal metastasis and primary liver tumors should be made before surgical exploration. Preservation of liver parenchyma is important with respect to liver failure and postoperative chemotherapy treatment.

scholarly journals Does Laparoscopic Liver Resection for Hepatocellular Carcinoma Reduce Posthepatectomy Liver Failure?

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S159
Author(s):  
Y. Uemoto ◽  
K. Taura ◽  
T. Nishio ◽  
Y. Kimura ◽  
N. Nam ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Liver Failure ◽  
Laparoscopic Liver Resection ◽  
Posthepatectomy Liver Failure

scholarly journals Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late‐onset hepatic failure in Japan

JGH Open ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 428-433
Author(s):  
Takuro Hisanaga ◽  
Isao Hidaka ◽  
Isao Sakaida ◽  
Nobuaki Nakayama ◽  
Akio Ido ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Corticosteroid Therapy ◽  
Hepatic Failure ◽  
Late Onset ◽  
Late Onset Hepatic Failure

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

scholarly journals The use of hemosorption in liver failure

1981 ◽  
Vol 62 (5) ◽  
pp. 6-9
Author(s):  
V. A. Sitnikov ◽  
V. V. Trusov ◽  
V. A. Lysenko ◽  
A. A. Ivanenkov
Keyword(s):  
Obstructive Jaundice ◽  
Liver Failure ◽  
Hepatic Failure ◽  
Hepatic Coma ◽  
Biliary Cirrhosis ◽  
Serum Hepatitis

The hemosorption method was applied in the treatment of 20 patients (30 hemosorptions). Indications for hemosorption were severe cholemic intoxication and liver failure in obstructive jaundice of gallstone and tumor etiology, hepatic coma in serum hepatitis, cholemic intoxication and liver failure in biliary cirrhosis, eclampsia and renal-hepatic failure. The efficiency and possible complications of hemosorption have been analyzed.

scholarly journals PALLIATIVE RESECTIONS OF A LIVER USING CRYODESTRUCTION FOR THE PATIENTS WHO HAVE BEEN REPEATEDLY OPERATED FOR ALVEOCOCCOSIS

2014 ◽  
Vol 13 (3) ◽  
pp. 25-31
Author(s):  
B. I. Alperovich ◽  
I. S. Zaytsev
Keyword(s):  
Surgical Treatment ◽  
Liver Resection ◽  
Compensatory Hypertrophy ◽  
Palliative Resection ◽  
Hepatic Insufficiency ◽  
Hepatoduodenal Ligament ◽  
Safe Method ◽  
Tissue Sections ◽  
Results Of Treatment ◽  
Vascular Structures

The purpose of work was the assessment of influence of a palliative resection of a liver with application of cryodestruction and without cryodestruction application on the remote results of treatment of the patients who have been repeatedly operated for alveococcosis.The analysis of surgical treatment of 14 patients operated repeatedly for alveococcosis of a liver is carried out. Patients were operated in the complicated stage of a disease in the presence of germination of a parasite in caval and/or portal gate of organ. Primary interventions were various – a diagnostic laparotomy, a cytoreduction and a marsupialization of a parasite, a liver resection. All patient at repetition intervention executed palliative resections of a liver. Resections were carried out by a clinic technique with imposing the ginglymoid of ligatures on remaining tissue of a liver at distance of 2–3 cm from the deleted parasitic knot taking into account a segmentary structure of organ. At all patients on "dangerous zones" (a zones of gate of a liver, a hepatoduodenal ligament) plates of parasitic fabric of various sizes from 1  2 cm to 2  4 cm were left. At 10 patients they were exposed to cryodestruction. The exposition in one point made from 1 to 2 minutes at a temperature –196 С. Postoperatively, patients received a dose of 10 mg/kg albendazole.Development of hepatic insufficiency after palliative resections of a liver is noted in one case. Lethal outcomes weren't.All patients for convenience of the analysis were divided into two groups: group of patients without application of cryotechnologies (n = 4) and group of the patients operated with application of cryodestruction (n = 10). Efficiency of palliative resections estimated on a median of survival of patients. Calculation of survival carried out Kaplan–Meier's method. The survival median in groups made 12 and 17 years respectively.When comparing survival of patients by Gehan's test with Yates's correction distinction of survival in two selections are statistically significant (z = 2,94; p < 0,005).Among patients repeatedly operated for alveococcosis when involving in parasitic process of gate of a liver, lack of possibility of prosthetics of vascular structures and developments of a compensatory hypertrophy of not struck departments of body the palliative resection allows to achieve survival of 50% of patients more than 16,8 years.Cryodestruction is the effective and safe method, allowing to increase survival of patients after a p alliative resection of a liver, through the destruction left in the area of the liver gate parasitic tissue sections.

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