Over-expression of La ribonucleoprotein domain family member 4B in human endometrial cancer.
Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified La ribonucleoprotein domain family member 4B, encoded by LARP4B, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. LARP4B was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of LARP4B was correlated with recurrence-free survival in white patients with high mutational burden. LARP4B may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.