scholarly journals CCDC155 is differentially expressed in metastasis to lymph nodes in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the brain and the breast resides the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in human breast cancer. We found that the coiled-coil domain containing 155, encoded by CCDC155, was among the genes whose expression was most different in the lymph nodes metastases of patients with metastatic breast cancer as compared to primary tumors of the breast (4). CCDC155 was also differentially expressed in the tumor cells of patients with triple negative breast cancer (5). CCDC155 mRNA was present at increased quantities in lymph node metastatic tissues as compared to primary tumors of the breast. Importantly, expression of CCDC155 in primary tumors was significantly correlated with patient recurrence-free survival, in lymph node positive patients but in lymph node negative patients. Modulation of CCDC155 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph node and to the brain in humans with metastatic breast cancer.

scholarly journals SP140L is differentially expressed in metastasis to lymph nodes in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the brain and the breast resides the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in human breast cancer. We found that the SP140 nuclear body protein like, encoded by SP140L, was among the genes whose expression was most different in the lymph nodes metastases of patients with metastatic breast cancer as compared to primary tumors of the breast (4). SP140L was also differentially expressed in the tumor cells of patients with triple negative breast cancer (5). SP140L mRNA was present at increased quantities in lymph node metastatic tissues as compared to primary tumors of the breast. Importantly, expression of SP140L in primary tumors was significantly correlated with patient overall survival, in lymph node positive patients but not in lymph node negative patients. Modulation of SP140L expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph node and to the brain in humans with metastatic breast cancer.

scholarly journals ZNF367 is differentially expressed in metastasis to lymph nodes in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the brain and the breast resides the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in human breast cancer. We found that the zinc finger protein 367, encoded by ZNF367, was among the genes whose expression was most different in the lymph nodes metastases of patients with metastatic breast cancer as compared to primary tumors of the breast4. ZNF367 was also differentially expressed in the tumor cells of patients with triple negative breast cancer5. ZNF367 mRNA was present at increased quantities in lymph node metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ZNF367 in primary tumors was significantly correlated with patient distant metastasis-free survival, in lymph node negative but not in lymph node positive breast cancer. Modulation of ZNF367 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

scholarly journals TSNAXIP1 is differentially expressed in metastasis to lymph nodes in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the brain and the breast resides the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in human breast cancer. We found that translin associated factor X interacting protein 1, encoded by TSNAXIP1, was among the genes whose expression was most different in the lymph nodes metastases of patients with metastatic breast cancer as compared to primary tumors of the breast4. TSNAXIP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer5. TSNAXIP1 mRNA was present at decreased quantities in lymph node metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TSNAXIP1 in primary tumors was significantly correlated with patient overall survival, in lymph node positive patients but in lymph node negative patients. Modulation of TSNAXIP1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph node and to the brain in humans with metastatic breast cancer.

scholarly journals DEFB123 is differentially expressed in metastasis to lymph nodes in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Differentially Expressed ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the brain and the breast resides the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in human breast cancer. We found that the defensin beta 123, encoded by DEFB123, was among the genes whose expression was most different in the lymph nodes metastases of patients with metastatic breast cancer as compared to primary tumors of the breast (4). DEFB123 was also differentially expressed in the primary tumors of the breast when compared to normal mammary epithelium (5). DEFB123 mRNA was present at increased quantities in lymph node metastatic tissues as compared to primary tumors of the breast. Importantly, expression of DEFB123 in primary tumors was significantly correlated with patient overall survival in patients with lymph node negative breast cancer. Modulation of DEFB123 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes in humans with metastatic breast cancer.

scholarly journals CR2 is differentially expressed in metastasis to lymph nodes in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Human Breast Cancer ◽  
Metastatic Breast ◽  
Differentially Expressed ◽  
Human Breast ◽  
Primary Tumors ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the brain and the breast resides the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in human breast cancer. We found that the complement component 3d receptor 2, encoded by CR2, was among the genes whose expression was most different in the lymph nodes metastases of patients with metastatic breast cancer as compared to primary tumors of the breast4. CR2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer5. CR2 mRNA was present at increased quantities in lymph node metastatic tissues as compared to primary tumors of the breast. Importantly, expression of CR2 in primary tumors was significantly correlated with patient recurrence-free survival. Modulation of CR2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

scholarly journals APOBEC3A is differentially expressed in lymph node metastases in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Human Breast ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that the apolipoprotein B mRNA editing enzyme catalytic subunit 3A, APOBEC3A, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that APOBEC3A was also differentially expressed in brain metastatic tissues. APOBEC3A mRNA was present at increased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of APOBEC3A in primary tumors of the breast was correlated with patient overall survival, more significantly in lymph node negative patients than in lymph node positive patients. Modulation of APOBEC3A expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer. APOBEC3A differential expression in lymph node metastatic tissues raises the question of why a human papillomavirus restriction factor (6, 7) is up-regulated during metastatic progression in human breast cancer.

scholarly journals COL16A1 is differentially expressed in lymph node metastasis in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Lymphoid Organ ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that collagen type XVI alpha 1 chain, COL16A1, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. COL16A1 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of COL16A1 in primary tumors of the breast was correlated with patient overall survival, in lymph node negative patients but not in lymph node positive patients. Modulation of COL16A1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.

scholarly journals COL6A1 is differentially expressed in lymph node metastasis in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Lymphoid Organ ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that collagen type VI alpha 1 chain, COL6A1, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. COL6A1 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of COL6A1 in primary tumors of the breast was correlated with patient post-progression survival, in lymph node negative patients but not in lymph node positive patients. Modulation of COL6A1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.

scholarly journals TSHZ3 is differentially expressed in lymph node metastasis in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that teashirt zinc finger homeobox 3, TSHZ3, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that TSHZ3 was also differentially expressed in brain metastatic tissues. TSHZ3 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of TSHZ3 in primary tumors of the breast was correlated with patient post-progression survival, in lymph node positive patients but not in lymph node negative patients. Modulation of TSHZ3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.

scholarly journals TMEM98 is differentially expressed in lymph node metastasis in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that transmembrane protein 98, TMEM98, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that TMEM98 was also differentially expressed in brain metastatic tissues. TMEM98 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of TMEM98 in primary tumors of the breast was correlated with patient overall survival, in lymph node positive patients but not in lymph node negative patients. Modulation of TMEM98 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.

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