Differential expression of ZW10 interacting kinetochore protein in cancers of the breast.

Primary Tumors ◽

Kinetochore Protein

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the ZW10 interacting kinetochore protein, ZWINT, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ZWINT was also differentially expressed in the tumor cells of patients with triple negative breast cancer. ZWINT mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ZWINT in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner, demonstrating a complex relationship between correlation of primary tumor expression with overall survival based on molecular subtype. ZWINT may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of M-phase phosphoprotein 9 in cancers of the breast.

10.31219/osf.io/b62ac ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

M Phase

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the M-phase phosphoprotein 9, MPHOSPH9, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MPHOSPH9 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MPHOSPH9 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MPHOSPH9 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. MPHOSPH9 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of ECT2 in cancers of the breast.

10.31219/osf.io/n8k3z ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding epithelial cell transforming 2, ECT2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ECT2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. ECT2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ECT2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner, demonstrating a complex relationship between correlation of primary tumor expression with overall survival based on molecular subtype. ECT2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of marker of proliferation Ki-67 in cancers of the breast.

10.31219/osf.io/4by8c ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Ki 67 ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding marker of proliferation Ki-67, MKI67, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MKI67 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MKI67 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MKI67 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. MKI67 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of synapse associated protein 1 in cancers of the breast.

10.31219/osf.io/efwqd ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Overall Survival ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Tumor Expression

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding synapse associated protein 1, SYAP1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SYAP1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. SYAP1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SYAP1 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between correlation of primary tumor expression with overall survival based on molecular subtype. SYAP1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of LIM domain binding 2 in cancers of the breast.

10.31219/osf.io/2ewxu ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Lim Domain ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding LIM domain binding 2, LDB2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. LDB2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of LDB2 in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal A subtype cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. LDB2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of mab-21 like 1 in cancers of the breast.

10.31219/osf.io/2gkba ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding mab-21 like 1, MAB21L1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MAB21L1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. MAB21L1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MAB21L1 in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. MAB21L1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of betaine--homocysteine S-methyltransferase 2 in cancers of the breast.

10.31219/osf.io/ac3v2 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Luminal B

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding betaine--homocysteine S-methyltransferase 2, BHMT2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. BHMT2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of BHMT2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. BHMT2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of defective in cullin neddylation 1 domain-containing 3 in cancers of the breast.

10.31219/osf.io/wgcqv ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding defective in cullin neddylation 1 domain-containing 3, DCUN1D3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DCUN1D3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DCUN1D3 in primary tumors of the breast was correlated with recurrence-free survival in patients with basal, luminal A and luminal B subtype cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. DCUN1D3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CXADR-like membrane protein in cancers of the breast.

10.31219/osf.io/tn6sp ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Membrane Protein ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding CXADR-like membrane protein, CLMP, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CLMP was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CLMP mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CLMP in primary tumors of the breast was correlated with overall survival in patients with basal-like, HER2+, and normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. CLMP may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of dystrophin in cancers of the breast.

10.31219/osf.io/yn2xe ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Luminal A ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dystrophin, DMD, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DMD was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DMD mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DMD in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. DMD may be of relevance to initiation, maintenance or progression of cancers of the female breast.