scholarly journals Developmental behavioral genetics research on school achievement is missing vulnerable children, to our detriment

2021 ◽  
Author(s):  
LaTasha R Holden ◽  
Rasheda Haughbrook ◽  
Sara Ann Hart
Keyword(s):  
Behavioral Genetics ◽  
Scientific Evidence ◽  
School Achievement ◽  
Interaction Model ◽  
Environment Interaction ◽  
White Children ◽  
Gene By Environment Interaction ◽  
Genetics Research ◽  
P Gene ◽  
Gene Environment

Gene–environment processes tell us how genes and environments work together to influence children in schools. One type of gene–environment process that has been extensively studied using behavioral genetics methods is a gene-by-environment interaction. A gene-by-environment interaction shows us when the effect of your context differs depending on your genes, or vice versa, when the effect of your genes differs depending on your context. Developmental behavioral geneticists interested in children’s school achievement have examined many different contexts within the gene-by-environment interaction model, including contexts measured from within children’s home and school environments. However, this work has been overwhelmingly focused on White children, leaving us with non-inclusive scientific evidence. This can lead to detrimental outcomes when we overgeneralize this non-inclusive scientific evidence to racialized groups. We conclude with a call to include racialized children in more research samples.

Influence of genetic factors and institutional environment on entrepreneurial activity: evidence from a twin study in Italy

2021 ◽  
Author(s):  
Diego Zunino
Keyword(s):  
Twin Study ◽  
Genetic Factors ◽  
Institutional Environment ◽  
Behavioral Genetics ◽  
Entrepreneurial Activity ◽  
Alternative Theory ◽  
Environment Interaction ◽  
Institutional Environments ◽  
Gene Environment Interaction ◽  
Gene Environment

Abstract Genetic factors influence entrepreneurial activity, but we know little about how genetic factors influence entrepreneurial activity when the institutional environment is favorable. Two theories from behavioral genetics explain the gene–environment interaction. One theory argues that a favorable environment favors the development of genetic factors and their influence. An alternative theory posits that unfavorable environment triggers the development of genetic factors and their influence. I test these two competing theories with a twin study based in Italy. I compare the influence of genetic factors in provinces where the institutional environment favors entrepreneurial activity with provinces where the institutional environment is unfavorable to entrepreneurial activity. I found consistent evidence that genetic factors exert a larger influence in favorable institutional environments, suggesting that favorable institutional environments complement genetic factors.

scholarly journals Genetic polymorphisms of key enzymes in folate metabolism affect the efficacy of folate therapy in patients with hyperhomocysteinaemia

2018 ◽  
Vol 119 (8) ◽  
pp. 887-895 ◽  
Author(s):  
Binghui Du ◽  
Huizi Tian ◽  
Dandan Tian ◽  
Chengda Zhang ◽  
Wenhua Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Interaction Model ◽  
Folate Metabolism ◽  
Efficacy Rate ◽  
Environment Interaction ◽  
Optimal Model ◽  
Acid Therapy ◽  
Gene Environment ◽  
History Of ◽  
Factor Interaction

AbstractThe aim of this study is to analyse the efficacy rate of folate for the treatment of hyperhomocysteinaemia (HHcy) and to explore how folate metabolism-related gene polymorphisms change its efficacy. This study also explored the effects of gene–gene and gene–environment interactions on the efficacy of folate. A prospective cohort study enrolling HHcy patients was performed. The subjects were treated with oral folate (5 mg/d) for 90 d. We analysed the efficacy rate of folate for the treatment of HHcy by measuring homocysteine (Hcy) levels after treatment. Unconditioned logistic regression was conducted to analyse the association between SNP and the efficacy of folic acid therapy for HHcy. The efficacy rate of folate therapy for HHcy was 56·41 %. The MTHFR rs1801133 CT genotype, TT genotype and T allele; the MTHFR rs1801131 AC genotype, CC genotype and C allele; the MTRR rs1801394 GA genotype, GG genotype and G allele; and the MTRR rs162036 AG genotype and AG+GG genotypes were associated with the efficacy of folic acid therapy for HHcy (P<0·05). No association was seen between other SNP and the efficacy of folic acid. The optimal model of gene–gene interactions was a two-factor interaction model including rs1801133 and rs1801394. The optimal model of gene–environment interaction was a three-factor interaction model including history of hypertension, history of CHD and rs1801133. Folate supplementation can effectively decrease Hcy level. However, almost half of HHcy patients failed to reach the normal range. The efficacy of folate therapy may be genetically regulated.

A Gene–Environment Interaction Model of Stress-Induced Hypertension

2005 ◽  
Vol 5 (2) ◽  
pp. 109-132 ◽  
Author(s):  
Ikhide G. Imumorin ◽  
Yanbin Dong ◽  
Haidong Zhu ◽  
Joseph C. Poole ◽  
Gregory A. Harshfield ◽  
...  
Keyword(s):  
Interaction Model ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Induced Hypertension
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