Development of gene‐environment interaction model in Drosophila for neurodegenerative disease: A step towards personalized medicine

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Souvarish Sarkar ◽  
Abby L Olsen ◽  
Mel B Feany
Keyword(s):  
Personalized Medicine ◽  
Neurodegenerative Disease ◽  
Interaction Model ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment

scholarly journals Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Andrea Maugeri ◽  
Martina Barchitta ◽  
Maria Grazia Mazzone ◽  
Francesco Giuliano ◽  
Antonella Agodi
Keyword(s):  
Public Health ◽  
Personalized Medicine ◽  
Macular Degeneration ◽  
Complement System ◽  
Genetic Variants ◽  
Age Related Macular Degeneration ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Age Related ◽  
Gene Environment

Age-related macular degeneration (AMD) is the most common cause of visual loss in developed countries, with a significant economic and social burden on public health. Although genome-wide and gene-candidate studies have been enabled to identify genetic variants in the complement system associated with AMD pathogenesis, the effect of gene-environment interaction is still under debate. In this review we provide an overview of the role of complement system and its genetic variants in AMD, summarizing the consequences of the interaction between genetic and environmental risk factors on AMD onset, progression, and therapeutic response. Finally, we discuss the perspectives of current evidence in the field of genomics driven personalized medicine and public health.

A Gene–Environment Interaction Model of Stress-Induced Hypertension

2005 ◽  
Vol 5 (2) ◽  
pp. 109-132 ◽  
Author(s):  
Ikhide G. Imumorin ◽  
Yanbin Dong ◽  
Haidong Zhu ◽  
Joseph C. Poole ◽  
Gregory A. Harshfield ◽  
...  
Keyword(s):  
Interaction Model ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Induced Hypertension

Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis

2006 ◽  
Vol 30 (5) ◽  
pp. 409-422 ◽  
Author(s):  
Silke Schmidt ◽  
Michael A. Schmidt ◽  
Xuejun Qin ◽  
Eden R. Martin ◽  
Elizabeth R. Hauser
Keyword(s):  
Linkage Analysis ◽  
Interaction Model ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Subset Analysis ◽  
Gene Environment ◽  
And Performance

Epigenetics and ADHD: Toward an Integrative Approach of the Disorder Pathogenesis

2017 ◽  
Vol 23 (7) ◽  
pp. 655-664 ◽  
Author(s):  
Meriem Hamza ◽  
Soumeyya Halayem ◽  
Soumaya Bourgou ◽  
Mona Daoud ◽  
Fatma Charfi ◽  
...  
Keyword(s):  
Stressful Life Events ◽  
Interaction Model ◽  
Specific Pattern ◽  
Current Data ◽  
Integrative Approach ◽  
Environment Interaction ◽  
Clinical Genetic ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Vasoactive Intestinal Peptide Receptor

Objective: Epigenetic hypothesis is one of the research pathways used to explain the complex etiology of neurodevelopmental disorders. This review highlights the findings of recent studies in the field of epigenetics in ADHD. Methods: An electronic literature search using Medline. Results: In the Gene × Environment interaction model, several clinical, genetic and molecular arguments support the epigenetic hypothesis in ADHD etiology. Environmental ADHD risk factors including toxic, nutritional factors and stressful life events lead to changes in DNA methylation and in histone modification levels. One critical CpG site located in the promoter of the DRD4 gene exhibited a specific pattern in ADHD children. A methylome wide exploration of DNA showed decreased methylation in vasoactive intestinal peptide receptor 2 gene, which was not replicated by further research. Conclusion: Current data require consolidation and could lead to the identification of biomarkers and the introduction of new modalities of treatment.

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