scholarly journals A Primer on Two-Stage Meta-Analysis with Individual Participant Data Obtained from Complex Sampling Surveys

2021 ◽  
Author(s):  
Diego Campos ◽  
Mike W.-L. Cheung ◽  
Ronny Scherer

The increasing availability of individual participant data (IPD) in the social sciences offers new possibilities to synthesize research evidence across primary studies. Two-stage IPD meta-analysis represents a framework that can utilize these possibilities. While most of the methodological research on two-stage IPD meta-analysis focused on its performance compared with other approaches, dealing with the complexities of the primary data has received little attention, particularly when IPD are drawn from complex sampling surveys. Complex sampling surveys often feature clustering, stratification, disproportionate sampling, and multiple stages of sample selection to obtain nationally or internationally representative data from a target population. Furthermore, IPD from these studies are likely to provide more than one effect size. To address the complexities of the primary and meta-analytic data obtained from complex surveys, we propose a two-stage IPD meta-analytic approach and illustrate its utility. To aid meta-analysts who wish to utilize complex survey data, we present a sequence of steps and discuss the methodological decisions and options within. Given its flexibility and ability to deal with the complex nature of the primary data, the proposed two-stage approach opens up new analytical possibilities for synthesizing knowledge meta-analytically.

Author(s):  
Lies Declercq ◽  
Laleh Jamshidi ◽  
Belén Fernández Castilla ◽  
Mariola Moeyaert ◽  
S. Natasha Beretvas ◽  
...  

2020 ◽  
Vol 88 (9) ◽  
pp. 829-843 ◽  
Author(s):  
Christoph Flückiger ◽  
Julian Rubel ◽  
A. C. Del Re ◽  
Adam O. Horvath ◽  
Bruce E. Wampold ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60650 ◽  
Author(s):  
Thomas P. A. Debray ◽  
Karel G. M. Moons ◽  
Ghada Mohammed Abdallah Abo-Zaid ◽  
Hendrik Koffijberg ◽  
Richard David Riley

2020 ◽  
Vol 2 (1) ◽  
pp. 12-30
Author(s):  
Tat-Thang Vo ◽  
Raphaël Porcher ◽  
Stijn Vansteelandt

Case mix differences between trials form an important factor that contributes to the statistical heterogeneity observed in a meta-analysis. In this paper, we propose two methods to assess whether important heterogeneity would remain if the different trials in the meta-analysis were conducted in one common population defined by a given case-mix. To achieve this goal, we first standardize results of different trials over the case-mix of a target population. We then quantify the amount of heterogeneity arising from case-mix and beyond case-mix reasons by using corresponding I2 statistics and prediction intervals. These new approaches enable a better understanding of the overall heterogeneity between trial results, and can be used to support standard heterogeneity assessments in individual participant data meta-analysis practice.


2020 ◽  
Vol 21 (04) ◽  
pp. 6-6

Flückiger C et al. The reciprocal relationship between alliance and early treatment symptoms: A two-stage individual participant data meta-analysis. J Consult Clin Psychol 2020. doi: 10.1037/ccp0000594 Die Therapeutische Allianz beschreibt die Verbindung von Behandler und Patient innerhalb des „therapeutischen Arbeitsbündnisses“ in der Psychotherapie und spielt eine wichtige Rolle für das Behandlungsergebnis. Da es bis heute unklar ist, in wieweit eine gute Allianz und frühe Symptomrückbildung zusammenhängen, legt Christoph Flückiger mit einem internationalen Expertenteam von 25 MitautorInnen nun die Ergebnisse einer 2-stufigen Primärdaten-Metaanalyse zum Thema vor.


2022 ◽  
Vol 12 (1) ◽  
pp. 93
Author(s):  
Pim Cuijpers ◽  
Marketa Ciharova ◽  
Soledad Quero ◽  
Clara Miguel ◽  
Ellen Driessen ◽  
...  

While randomized trials typically lack sufficient statistical power to identify predictors and moderators of outcome, “individual participant data” (IPD) meta-analyses, which combine primary data of multiple randomized trials, can increase the statistical power to identify predictors and moderators of outcome. We conducted a systematic review of IPD meta-analyses on psychological treatments of depression to provide an overview of predictors and moderators identified. We included 10 (eight pairwise and two network) IPD meta-analyses. Six meta-analyses showed that higher baseline depression severity was associated with better outcomes, and two found that older age was associated with better outcomes. Because power was high in most IPD meta-analyses, non-significant findings are also of interest because they indicate that these variables are probably not relevant as predictors and moderators. We did not find in any IPD meta-analysis that gender, education level, or relationship status were significant predictors or moderators. This review shows that IPD meta-analyses on psychological treatments can identify predictors and moderators of treatment effects and thereby contribute considerably to the development of personalized treatments of depression.


Sign in / Sign up

Export Citation Format

Share Document