scholarly journals Zeolite Catalyzed Aldol Condensation Reactions

2015 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Adedayo I. Inegbenebor ◽  
Raphael C. Mordi ◽  
Oluwakayode M. Ogunwole
Keyword(s):  
Lewis Acids ◽  
Active Sites ◽  
Aldol Condensation ◽  
Condensation Product ◽  
Acid Sites ◽  
Weak Acid ◽  
Aldol Reactions ◽  
Condensation Reactions ◽  
Silica Alumina ◽  
Aldol Condensation Reactions

The review is based on the description of zeolite structure, uses, synthesis, and catalytic aldol reaction in aldol condensation. An internal aldolcondensation reaction has been achieved over ZSM-5 zeolite with high silica-alumina ratio at 350oC. It therefore follows that zeolite canfunction as a catalyst in aldol type condensation reactions and that weak acid sites as well as a small number of active sites favor the aldolcondensation reaction of carbonyl compounds. However, the mixed condensation product was found to be favored at temperatures above 300oCand the self-condensation of ethanal to crotonaldehyde was favored at temperatures below 300oC. It has also been suggested that both Brønstedand Lewis acids are involved in aldol reactions with Lewis acid sites the most probable catalytic sites. The zeolite group of minerals has founduse in many chemical and allied industries.DOI: http://dx.doi.org/10.3126/ijasbt.v3i1.12291  Int J Appl Sci Biotechnol, Vol. 3(1): 1-8 

Recent advancement and novel application of organocatalyzed aldol condensation reactions: A comprehensive review

2022 ◽  
Vol 19 ◽  
Author(s):  
Ajay Kumar Verma ◽  
Braj Nandan Kishor ◽  
Om Prakash
Keyword(s):  
Amino Acids ◽  
Aldol Condensation ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Addition Product ◽  
Aldol Reactions ◽  
Hydroxy Ketone ◽  
Unsaturated Ketone ◽  
Condensation Reactions ◽  
Aldol Condensation Reactions

Background: Aldol reactions play an important role in the development of organic synthesis-owing to their critical importance for the forming of carbon-carbon bonds while concurrently one or two chiral centers come into being. In the modern scenario, the Aldol condensation reaction has arisen as perhaps the most significant reaction for the formation of novel medicinal agents exhibits promising pharmacological activities. Objective: The purpose of this study is to present newer synthetic approaches through Aldol condensation reaction for the synthesis of diverse scaffolds to explore the promising various types of biological activities. Methods: Aldol condensation concerns the nucleophilic addition reaction of a ketone enolate to an aldehyde to form aldol or β- hydroxy ketone. Occasionally, the aldol addition product losing water molecule yields an α, β-unsaturated ketone. Results: Results showed that amino acids and all lengths of peptides are utilized as chiral catalysts. As of now, the arrangement of catalysts that have been accounted for is intensely one-sided towards proline. This is to some degree because of its exceptional status among the normally happening amino acids as an auxiliary amine and to its restricted underlying adaptability. Conclusion: The present study thus provides useful insight concerning the promising coherent way for the synthesis of prolinamide analogue of proline, through a direct asymmetric aldol condensation reaction. Thus, the current study summarizes various Aldol condensation reactions for the synthesis of novel agents as well as their promising pharmacological importance.

ChemInform Abstract: A Diphenylprolinol TMS Ether/Bile Acid Organocatalytic System for the Asymmetric Domino Sulfa-Michael/Aldol Condensation Reactions of 1,4-Dithiane-2,5-diol and Cinnamaldehydes.

ChemInform ◽  
2010 ◽  
Vol 41 (24) ◽  
pp. no-no
Author(s):  
Nikla Baricordi ◽  
Simonetta Benetti ◽  
Carmela De Risi ◽  
Marco Fogagnolo ◽  
Gian Piero Pollini ◽  
...  
Keyword(s):  
Bile Acid ◽  
Aldol Condensation ◽  
Condensation Reactions ◽  
Aldol Condensation Reactions

Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis ofN-Hydroxypyrroles

2009 ◽  
Vol 121 (4) ◽  
pp. 772-775 ◽  
Author(s):  
Bin Tan ◽  
Zugui Shi ◽  
Pei Juan Chua ◽  
Yongxin Li ◽  
Guofu Zhong
Keyword(s):  
Aldol Condensation ◽  
Condensation Reactions ◽  
Aldol Condensation Reactions

Supported Choline Hydroxide (Ionic Liquid) as Heterogeneous Catalyst for Aldol Condensation Reactions.

ChemInform ◽  
2004 ◽  
Vol 35 (36) ◽  
Author(s):  
Sonia Abello ◽  
Francisco Medina ◽  
Xavier Rodriguez ◽  
Yolanda Cesteros ◽  
Pilar Salagre ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Heterogeneous Catalyst ◽  
Aldol Condensation ◽  
Condensation Reactions ◽  
Aldol Condensation Reactions

scholarly journals Development of pharmaceutically relevant bio-based intermediates though aldol condensation and Claisen–Schmidt reactions of dihydrolevoglucosenone (Cyrene®)

2018 ◽  
Vol 20 (19) ◽  
pp. 4423-4427 ◽  
Author(s):  
Liam Hughes ◽  
Con R. McElroy ◽  
Adrian C. Whitwood ◽  
Andrew J. Hunt
Keyword(s):  
Aldol Condensation ◽  
Condensation Reactions ◽  
Aldol Condensation Reactions

Dihydrolevoglucosenone (Cyrene®) has been successfully utilised as a bio-based platform molecule for the synthesis of pharmaceutically relevant intermediates through aldol condensation reactions.

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