scholarly journals Surgical Management of Locally Advanced Breast Cancer: Recommendations of the Brazilian Society of Surgical Oncology

2021 ◽  
pp. 1-10
Author(s):  
Rene Aloisio da Costa Vieira ◽  
Rene Aloisio da Costa Vieira ◽  
Wesley Pereira Andrade ◽  
Sabas Carlos Vieira ◽  
Mauricio Romano ◽  
...  
Keyword(s):  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Tumor Biology ◽  
Surgical Oncology ◽  
Clinical Findings ◽  
Advanced Breast ◽  
Oncological Surgery ◽  
Brazilian Society ◽  
Therapy Choice ◽  
Surgical Aspects

The Brazilian Society of Oncological Surgery organized a group of oncological surgeons to discuss surgical aspects associated with locally advanced breast carcinoma. This article reviews the indications, the different surgeries (especially those associated with thoracoabdominal or myocutaneous flaps), and associated complications. It discusses special conditions such as invasion of the chest wall and interscapular thoracic disarticulation. It makes recommendations based on the literature regarding clinical findings, tumor conditions, response to neoadjuvant therapy, choice of flaps in surgery, and tumor biology.

Preoperative Paclitaxel and Radiotherapy for Locally Advanced Breast Cancer: Surgical Aspects

2000 ◽  
Vol 7 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Kristin A. Skinner ◽  
Howard Silberman ◽  
Barbara Florentine ◽  
Thomas J. Lomis ◽  
Francesca Corso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Surgical Aspects

scholarly journals Predicting Response to Neoadjuvant Chemotherapy in Women with Locally Advanced Breast Cancer in Kenya: Utility of Ki67

2021 ◽  
Vol 18 (1) ◽  
pp. 23-28
Author(s):  
Edwin Mogere ◽  
Joseph Githaiga ◽  
Francis Owilla ◽  
Mary Mungania ◽  
Daniel Ojuka
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Advanced Breast Cancer ◽  
Tumor Size ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Tumor Biology ◽  
Advanced Breast ◽  
P Value ◽  
Response To Neoadjuvant Chemotherapy

Background: Ki67 levels have been shown to have good predictive value in breast cancer treatment. There is paucity of data on Ki67 levels in predicting response to neoadjuvant chemotherapy (NACT) in Kenya. This study evaluated the utility of Ki67 in predicting response to NACT. Methods: This was a prospective observational study carried out at Kenyatta National Hospital between December 2017 and January 2019 onpatients with locally advanced breast cancer. We recruited 61 women through consecutive sampling technique. Data collected included patient demographics, pre-treatment tumor size, Ki67 levels and tumor biology. After 3 cycles of first-line chemotherapy, ultrasonography was used to determine response. Data were analyzed by SPSS for proportion of change in tumor size. The response was correlated with tumor biology and pretreatment levels of Ki67 using chisquare at a 95% confidence interval. A p-value <0.05 was considered statistically significant. Results: The response rate after 3 cycles of NACT was 39.4%, sensitivity and specificity of Ki67 levels were 70.8% and 43.2% respectively with a cut-off value of 32.5%. Conclusions: Ki67 was found to predict response in our context at a rate of 39.4% at 20% cutoff after 3 cycles. Keywords: Ki67, Breast cancer, Neoadjuvant chemotherapy

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