Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study

2019 ◽  
Author(s):  
Keyword(s):  
Fear Extinction ◽  
Extinction Learning

scholarly journals Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors

2015 ◽  
Vol 9 ◽  
Author(s):  
Alexandra Wille ◽  
Verena Maurer ◽  
Paolo Piatti ◽  
Nigel Whittle ◽  
Dietmar Rieder ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Fear Extinction ◽  
Extinction Learning ◽  
Contextual Fear

Fear extinction learning and retention during adolescence in rats and mice: A systematic review

2021 ◽  
Vol 131 ◽  
pp. 1264-1274
Author(s):  
Madelyne A. Bisby ◽  
A.A. Stylianakis ◽  
K.D. Baker ◽  
R. Richardson
Keyword(s):  
Systematic Review ◽  
Fear Extinction ◽  
Extinction Learning ◽  
Rats And Mice

scholarly journals Caloric Restriction Enhances Fear Extinction Learning in Mice

2013 ◽  
Vol 38 (6) ◽  
pp. 930-937 ◽  
Author(s):  
Megan C Riddle ◽  
Morgan C McKenna ◽  
Yone J Yoon ◽  
Siobhan S Pattwell ◽  
Patricia Mae G Santos ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Fear Extinction ◽  
Extinction Learning

scholarly journals Aerobic Exercise And Consolidation Of Fear Extinction Learning Among Women With Posttraumatic Stress Disorder

2021 ◽  
Vol 53 (8S) ◽  
pp. 303-304
Author(s):  
Kevin M. Crombie ◽  
Anneliis Sartin-Tarm ◽  
Kyrie Sellnow ◽  
Rachel Ahrenholtz ◽  
Sierra Lee ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Aerobic Exercise ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Fear Extinction ◽  
Extinction Learning

scholarly journals Fear extinction learning improvement in PTSD after EMDR therapy: an fMRI study

2019 ◽  
Vol 10 (1) ◽  
pp. 1568132 ◽  
Author(s):  
Pierre-François Rousseau ◽  
Myriam El Khoury-Malhame ◽  
Emmanuelle Reynaud ◽  
Sarah Boukezzi ◽  
Aïda Cancel ◽  
...  
Keyword(s):  
Fear Extinction ◽  
Extinction Learning ◽  
Learning Improvement ◽  
Fmri Study ◽  
Emdr Therapy

Intra‐amygdala metaplasticity modulation of fear extinction learning

2020 ◽  
Author(s):  
Rinki Saha ◽  
Martin Kriebel ◽  
Rachel Anunu ◽  
Hansjuergen Volkmer ◽  
Gal Richter‐Levin
Keyword(s):  
Fear Extinction ◽  
Extinction Learning

scholarly journals The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning

2018 ◽  
Vol 91 ◽  
pp. 142-148 ◽  
Author(s):  
Kim L. Felmingham ◽  
Daniel V. Zuj ◽  
Ken Chia Ming Hsu ◽  
Emma Nicholson ◽  
Matthew A. Palmer ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Fear Extinction ◽  
Extinction Learning ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
The Relationship

scholarly journals Stress during puberty boosts metabolic activation associated with fear-extinction learning in hippocampus, basal amygdala and cingulate cortex

2012 ◽  
Vol 98 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Maria Toledo-Rodriguez ◽  
Alain Pitiot ◽  
Tomáš Paus ◽  
Carmen Sandi
Keyword(s):  
Metabolic Activation ◽  
Cingulate Cortex ◽  
Fear Extinction ◽  
Extinction Learning ◽  
Basal Amygdala

scholarly journals 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning

2015 ◽  
Vol 5 (9) ◽  
pp. e634-e634 ◽  
Author(s):  
M B Young ◽  
R Andero ◽  
K J Ressler ◽  
L L Howell
Keyword(s):  
Fear Extinction ◽  
Extinction Learning

scholarly journals GluN2D NMDA Receptors Gate Fear Extinction Learning and Interneuron Plasticity

2021 ◽  
Vol 13 ◽  
Author(s):  
Christophe J. Dubois ◽  
Siqiong June Liu
Keyword(s):  
Nmda Receptor ◽  
Fear Conditioning ◽  
Learning And Memory ◽  
Molecular Layer ◽  
Gaba Release ◽  
Long Term Potentiation ◽  
Fear Extinction ◽  
Fear Learning ◽  
Inhibitory Synapses ◽  
Extinction Learning

The cerebellum is critically involved in the formation of associative fear memory and in subsequent extinction learning. Fear conditioning is associated with a long-term potentiation at both excitatory and inhibitory synapses onto Purkinje cells. We therefore tested whether fear conditioning unmasks novel forms of synaptic plasticity, which enable subsequent extinction learning to reset cerebellar circuitry. We found that fear learning enhanced GABA release from molecular layer interneurons and this was reversed after fear extinction learning. Importantly an extinction-like stimulation of parallel fibers after fear learning is sufficient to induce a lasting decrease in inhibitory transmission (I-LTDstim) in the cerebellar cortex, a form of plasticity that is absent in naïve animals. While NMDA (N-methyl-D-aspartate) receptors are required for the formation and extinction of associative memory, the role of GluN2D, one of the four major NMDA receptor subunits, in learning and memory has not been determined. We found that fear conditioning elevates spontaneous GABA release in GluN2D KO as shown in WT mice. Deletion of GluN2D, however, abolished the I-LTDstim induced by parallel fiber stimulation after learning. At the behavioral level, genetic deletion of GluN2D subunits did not affect associative learning and memory retention, but impaired subsequent fear extinction learning. D-cycloserine, a partial NMDA receptor (NMDAR) agonist, failed to rescue extinction learning in mutant mice. Our results identify GluN2D as a critical NMDAR subunit for extinction learning and reveal a form of GluN2D-dependent metaplasticity that is associated with extinction in the cerebellum.

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