Radical Prostatectomy Versus Radical Radiotherapy for Locally Advanced Prostate Cancer

2019 ◽  
Author(s):  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Radical Radiotherapy ◽  
Locally Advanced Prostate Cancer

scholarly journals Variation in usage of radical prostatectomy and radical radiotherapy for men with locally advanced prostate cancer

2017 ◽  
Vol 10 (1_suppl) ◽  
pp. 34-38 ◽  
Author(s):  
Luke Hounsome ◽  
Ed Rowe ◽  
Julia Verne ◽  
Roger Kockelbergh ◽  
Heather Payne
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Hormone Therapy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Radical Radiotherapy ◽  
Locally Advanced Prostate Cancer ◽  
Comorbidity Score ◽  
Radical Treatment ◽  
Charlson Comorbidity Score

Locally advanced prostate cancer is defined as primary tumours extending outside the prostate gland to the surrounding tissues or seminal vesicles but without spread beyond the pelvic region. With radical treatment there is good prospect of cure. Radiotherapy in combination with hormone therapy is well established, but specific NICE guidelines have only recently been published. The guidelines recommend offering either radical prostatectomy (RP), possibly with adjuvant radiotherapy, or radical radiotherapy (RT) with neo-adjuvant hormone therapy as treatment for men with locally advanced prostate cancer. Given that guidelines on managing locally advanced prostate cancer have recently changed, we wanted to quantify the baseline variation in use of radical treatments for this patient group. Methods: Men with T3/T4 N0 M0 prostate cancer who were diagnosed in 2010–2012 were identified using data from the National Cancer Registration and Analysis Service (NCRAS). Data on age, ethnicity, deprivation, Charlson comorbidity score, Strategic Clinical Network (SCN) of residence, and treatments delivered were extracted. A multivariable logistic regression was undertaken to identify important variables. Results: Overall, 1692 (14%) of men in the cohort had a record of radical prostatectomy. A total of 6212 (52%) had a record of curative RT. In a regression model each decade increase in age yielded odds of 0.39 ( p < 0.001) for receiving radical treatment. Black men were only half as likely as white men to receive radical treatment (OR = 0.54; p < 0.001). Deprivation, comorbidity and SCN of residence had smaller effects. The variation observed in radical treatment between SCNs largely disappeared once the multiple variables were accounted for. Conclusion: Radical treatments vary by 71% to 85% between networks for men aged 60–69 years. Given that men >80 years made up 12% of the study population and only 6% had a Charlson comorbidity score >0, there is a possibility that some men with ‘clinically significant’ disease are undertreated.

Multimodal treatment for high-risk locally-advanced prostate cancer following radical prostatectomy and extended lymphadenectomy

2019 ◽  
Vol 71 (5) ◽  
Author(s):  
Fabio Zattoni ◽  
Alessandro Morlacco ◽  
Fabio Matrone ◽  
Mauro Arcicasa ◽  
Lorenzo Buttazzi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Multimodal Treatment ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Extended Lymphadenectomy ◽  
Locally Advanced Prostate Cancer

scholarly journals Knowledge, attitudes and beliefs towards management of men with locally advanced prostate cancer following radical prostatectomy: an Australian survey of urologists

2016 ◽  
Vol 117 ◽  
pp. 35-44 ◽  
Author(s):  
Bernadette Brown ◽  
Jane Young ◽  
Andrew B Kneebone ◽  
Andrew J Brooks ◽  
Amanda Dominello ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Attitudes And Beliefs ◽  
Locally Advanced Prostate Cancer

Laparoscopic radical prostatectomy for locally advanced prostate cancer: our initial results

2011 ◽  
Vol 37 (1) ◽  
pp. 14-19
Author(s):  
Murat Binbay ◽  
Tolga Akman ◽  
Cem Kezer ◽  
Mehmet Kaba ◽  
Yalcin Berberoglu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Laparoscopic Radical Prostatectomy ◽  
Locally Advanced Prostate Cancer ◽  
Initial Results

911 Oncological outcome and prognostic factors for locally advanced prostate cancer treated with radical prostatectomy: An EMPaCT study

2013 ◽  
Vol 12 (1) ◽  
pp. e911
Author(s):  
C.Y. Hsu ◽  
M. Spahn ◽  
A. Briganti ◽  
J. Karnes ◽  
P. Gontero ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factors ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Oncological Outcome ◽  
Locally Advanced Prostate Cancer

Laparoscopic radical prostatectomy for locally advanced prostate cancer: a retrospective study

2019 ◽  
Vol 18 (12) ◽  
pp. e3632
Author(s):  
David Nikoleishvili ◽  
Givi Koberidze ◽  
Zaza Tchanturaia ◽  
Ambrosi Pertia
Keyword(s):  
Prostate Cancer ◽  
Retrospective Study ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Laparoscopic Radical Prostatectomy ◽  
Locally Advanced Prostate Cancer

The complications of radical prostatectomy for locally advanced prostate cancer

2019 ◽  
Vol 18 (2) ◽  
pp. e2324
Author(s):  
S. Conachiu ◽  
G. Predoiu ◽  
R. Danau ◽  
C. Calin ◽  
V. Jinga ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Locally Advanced Prostate Cancer

Radical Prostatectomy for Locally Advanced Prostate Cancer

2016 ◽  
pp. 657-663
Author(s):  
Ali S. Gözen ◽  
Yiğit Akın ◽  
Jens J. Rassweiler
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Locally Advanced Prostate Cancer
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