Effects of increased ICP on brain phosphocreatine and lactate determined by simultaneous 1H and 31P NMR spectroscopy

1987 ◽  
Vol 67 (3) ◽  
pp. 381-386 ◽  
Author(s):  
Leslie N. Sutton ◽  
Alan C. McLaughlin ◽  
William Kemp ◽  
M. D. Schnall ◽  
Byung-Ku Cho ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cerebral Perfusion ◽  
31P Nmr ◽  
Perfusion Pressure ◽  
Brain Energy Metabolism ◽  
Resonance Spectroscopy ◽  
31P Nmr Spectroscopy ◽  
Content Type ◽  
Brain Energy ◽  
Increased Icp

✓ In order to study the metabolic events surrounding ischemia induced by the graded increase of cerebrospinal fluid (CSF) pressure, the technique of simultaneous phosphorus-31- and hydrogen-1-enhanced nuclear magnetic resonance spectroscopy was applied to five cats as intracranial pressure (ICP) was gradually raised by the instillation of mock CSF. Threshold lactate rose at an average cerebral perfusion pressure (CPP) of 49 torr, and, in general, preceded a threshold decrease in phosphocreatine, which was observed at an average CPP of 29 torr. There was considerable variation among cats in the CPP at which failure of brain energy metabolism occurred, however, suggesting differences in the autoregulatory curves. It is concluded that, with elevated ICP, there is no universally “safe” CPP at which brain energy metabolism may be assumed to be uncompromised.

Cerebral venous oxygen content as a measure of brain energy metabolism with increased intracranial pressure and hyperventilation

1990 ◽  
Vol 73 (6) ◽  
pp. 927-932 ◽  
Author(s):  
Leslie N. Sutton ◽  
Alan C. McLaughlin ◽  
Stephen Dante ◽  
Mark Kotapka ◽  
Teresa Sinwell ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Intracranial Pressure ◽  
Oxygen Content ◽  
Brain Energy Metabolism ◽  
Resonance Spectroscopy ◽  
Increased Intracranial Pressure ◽  
Content Type ◽  
Venous Oxygen Content ◽  
Standard Deviation Range ◽  
Brain Energy

✓ In order to test the hypothesis that the cerebral arteriovenous oxygen difference (AVDO2) and venous oxygen content (VO2) could be used to monitor brain energy metabolism in the setting of increased intracranial pressure (ICP), 12 cats were studied with 31P-magnetic resonance spectroscopy. Six cats were subjected to intracranial hypertension by cisternal infusion of saline. Energy failure occurred at an average AVDO2 of 8.4 ± 3.2 vol% (± standard deviation) (range 4.7 to 14.7 vol%). The VO2 at the point of metabolic failure averaged 1.45 ± 0.6 vol% and extended over a narrower range (1.0 to 2.9 vol%). In an additional six cats, ICP was raised to the threshold of metabolic failure and hyperventilation was then instituted (pCO2 10 to 18 torr). Five of the six cats experienced a drop in VO2 with hyperventilation. In two of these animals, hyperventilation resulted in a VO2 of 1.1 vol% or less and in metabolic failure as evidenced by a fall in phosphocreatine. It is concluded that a VO2 of less than 2 vol% is correlated with brain ischemia and that the safety of hyperventilation in the setting of increased ICP can be monitored by the use of VO2.

Depolarizing high-[K+] load model of rat brain energy metabolism: α 31P-NMR study

2009 ◽  
Vol 65 ◽  
pp. S128
Author(s):  
Osamu Tokumaru ◽  
Chihiro Kuroki ◽  
Kazue Ogata ◽  
Takaaki Kitano ◽  
Isao Yokoi
Keyword(s):  
Energy Metabolism ◽  
Rat Brain ◽  
31P Nmr ◽  
Brain Energy Metabolism ◽  
Load Model ◽  
Nmr Study ◽  
High K ◽  
Brain Energy

scholarly journals Brain Energy Metabolism in Two States of Mind Measured by Phosphorous Magnetic Resonance Spectroscopy

2021 ◽  
Vol 15 ◽  
Author(s):  
Malik Galijašević ◽  
Ruth Steiger ◽  
Milovan Regodić ◽  
Michaela Waibel ◽  
Patrick Julian David Sommer ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Basal Ganglia ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Functional Neuroimaging ◽  
Brain Energy Metabolism ◽  
Resonance Spectroscopy ◽  
Focused Attention ◽  
Awake State ◽  
Brain Energy

Introduction: Various functional neuroimaging studies help to better understand the changes in brain activity during meditation. The purpose of this study was to investigate how brain energy metabolism changes during focused attention meditation (FAM) state, measured by phosphorous magnetic resonance spectroscopy (31P-MRS).Methods:31P-MRS imaging was carried out in 27 participants after 7 weeks of FAM training. Metabolite ratios and the absolute values of metabolites were assessed after meditation training in two MRI measurements, by comparing effects in a FAM state with those in a distinct focused attention awake state during a backwards counting task.Results: The results showed decreased phosphocreatine/ATP (PCr/ATP), PCr/ inorganic phosphate (Pi), and intracellular pH values in the entire brain, but especially in basal ganglia, frontal lobes, and occipital lobes, and increased Pi/ATP ratio, cerebral Mg, and Pi absolute values were found in the same areas during FAM compared to the control focused attention awake state.Conclusions: Changes in the temporal areas and basal ganglia may be interpreted as a higher energetic state induced by meditation, whereas the frontal and occipital areas showed changes that may be related to a down-regulation in ATP turnover, energy state, and oxidative capacity.

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