Pre-emptive Renal Transplantation: Optimum Treatment for End-Stage Renal Disease?

Renal transplantation (RT) prior to having dialysis or pre-emptive renal transplantation (PRT) hasbeen controversial because of the paucity of clinical evidence to clarify the benefi ts and risks of PRT.The recent emergence of evidences from major transplant centres in the United Kingdom and UnitedStates have confi rmed the survival advantages for both renal allografts and RT recipients. Hence anincreasing number of transplant centres are adopting the practice of PRT. This article discusses theadvantages and disadvantages of PRT and highlights the clinical evidences in support of PRT.Key Words: Dialysis, kidney transplantation, pre-emptive renal transplantation

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CYTOMEGALOVIRUS INFECTION IN IMMUNOSUPPRESSED PATIENTS AFTER KIDNEY TRANSPLANTATION

Medicine and Pharmacy Reports ◽

10.15386/cjmed-587 ◽

2016 ◽

Vol 89 (3) ◽

pp. 343-346 ◽

Cited By ~ 2

Author(s):

Simona Luscalov ◽

Luminita Loga ◽

Lucia Dican ◽

Lia Monica Junie

Keyword(s):

Kidney Transplantation ◽

Renal Transplantation ◽

Renal Disease ◽

End Stage Renal Disease ◽

Cmv Infection ◽

Living Donor Transplantation ◽

Important Solution ◽

Immunosuppressed Patients ◽

Stage Renal Disease ◽

End Stage

The first kidney transplantation was performed in 1951 and ever since then living donor transplantation became a more and more important solution for patients with end-stage renal disease (ESRD).Renal transplantation is a life-saving procedure. Morbidity and mortality on waiting-lists are strongly correlated with the time of dialysis and end-stage renal disease is one of the most important causes of death; this is the reason why transplantation has to be performed as soon as possible in order to reduce the time of dialysis.Once the transplantation is performed, a number of complications may occur in post-transplant evolution, the most important of which is rejection.The rejection may appear through several mechanisms, but one of the most frequent causes of rejection is cytomegalovirus (CMV) infection. It is very important to have a precocious and fast diagnosis of CMV infection in order to maintain the functionality and survival of the graft. PP65 CMV antigenemia has proven its effectiveness in detecting and monitoring the CMV infection in transplanted patients.In the laboratory of the Clinical Institute of Urology and Renal Transplantation (ICUTR) of Cluj Napoca the CMV infection is evidenced by two methods: PP65antigenemia and IgM antibody identification by chemiluminiscence.

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Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis

International Journal of Impotence Research ◽

10.1038/s41443-021-00419-6 ◽

2021 ◽

Author(s):

Irham Arif Rahman ◽

Nur Rasyid ◽

Ponco Birowo ◽

Widi Atmoko

Keyword(s):

Systematic Review ◽

Erectile Dysfunction ◽

Kidney Transplantation ◽

Renal Transplantation ◽

End Stage Renal Disease ◽

Erectile Function ◽

Meta Analysis ◽

Post Transplantation ◽

Stage Renal Disease ◽

End Stage

AbstractErectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function.

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