Fusion imaging with contrast-enhanced ultrasonography for evaluating the early therapeutic efficacy of radiofrequency ablation for small hypervascular hepatocellular carcinomas with iso-echoic or unclear margins on conventional ultrasonography

Choonpa Igaku ◽  
2020 ◽  
Vol 47 (2) ◽  
pp. 81-91
Author(s):  
Shuhei NISHIGORI ◽  
Kazushi NUMATA ◽  
Kuniyasu IRIE ◽  
Hiroyuki FUKUDA ◽  
Makoto CHUMA ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Therapeutic Efficacy ◽  
Fusion Imaging ◽  
Hepatocellular Carcinomas ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

scholarly journals Percutaneous Radiofrequency Ablation of Small (1–2 cm) Hepatocellular Carcinomas Inconspicuous on B-Mode Ultrasonographic Imaging: Usefulness of Combined Fusion Imaging with MRI and Contrast-Enhanced Ultrasonography

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Min Woo Lee ◽  
Hyo Keun Lim ◽  
Hyunchul Rhim ◽  
Dong Ik Cha ◽  
Tae Wook Kang ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Fusion Imaging ◽  
Local Tumor Progression ◽  
Percutaneous Radiofrequency Ablation ◽  
Technical Success ◽  
Local Tumor ◽  
Hepatocellular Carcinomas ◽  
Therapeutic Outcomes ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

Purpose. To assess usefulness of adding contrast-enhanced ultrasonography (CEUS) to fusion imaging (FI) for percutaneous radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs) inconspicuous on FI alone. Therapeutic outcomes of RFA under CEUS-added FI guidance for HCCs inconspicuous on FI alone were also evaluated. Methods. This prospective study was approved by the institutional review board and informed consent was obtained from all patients. Planning US was performed with FI for 126 patients with a single HCC (1–2 cm) to evaluate the feasibility of RFA by grading lesion conspicuity score using a four-point scale. RFA was performed under CEUS-added FI guidance for HCCs inconspicuous on FI alone. We evaluated how many HCCs initially inconspicuous on FI became conspicuous after adding CEUS. After CEUS-added FI-guided RFA, therapeutic outcomes including rates of technical success, primary technique efficacy, major complications, and local tumor progression were assessed. Results. After adding CEUS, 90.5% (19/21) of all tumors initially inconspicuous on FI became conspicuous, thus enabling direct targeting for RFA. Technical success and primary technique efficacy rates were 94.7% (18/19) and 100% (19/19), respectively. No major complications were observed after RFA. Cumulative local tumor progression rates after RFA were estimated to be 5.3%, 10.8%, and 10.8% at 1, 2, and 3 years, respectively. Conclusion. Adding CEUS to FI is useful for improving the conspicuity of HCCs inconspicuous on FI alone, thus enabling successful percutaneous RFA with excellent therapeutic outcomes.

scholarly journals Contrast-enhanced ultrasonography features of hepatobiliary neoplasms in cats

2019 ◽  
Vol 186 (10) ◽  
pp. 320-320 ◽  
Author(s):  
Tommaso Banzato ◽  
Silvia Burti ◽  
Giuseppe Rubini ◽  
Riccardo Orlandi ◽  
Paolo Bargellini ◽  
...  
Keyword(s):  
Bile Duct ◽  
Diagnostic Accuracy ◽  
Large Range ◽  
Liver Parenchyma ◽  
Qualitative And Quantitative ◽  
Hepatocellular Carcinomas ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Malignant Lesions

BackgroundContrast-enhanced ultrasonography (CEUS) features of primary hepatobiliary neoplasms have been reported in dogs but no information is available in cats.MethodsQualitative and quantitative features of bile duct adenomas (BDAs, n=20), bile duct carcinomas (BDCs, n=16), and hepatocellular carcinomas (HCCs, n=8) are described in 44 cats.ResultsThere was an overlap in CEUS qualitative features between different histotypes, both in wash-in and wash-out phases. Distinction between different neoplasms based only on the CEUS qualitative features was not possible. At peak of enhancement, the BDAs, BDCs and HCCs showed a large range of echogenicities, from hypoenhancement to hyperenhancement, in comparison to the liver parenchyma. Eight of 20 BDAs showed inhomogeneous hyperenhancement during wash-in, which is a feature reported as typical of malignant lesions in dogs. BDC had a significantly faster wash-in compared with both BDA and HCC but the diagnostic accuracy of all the included quantitative variables was only moderate. No significant differences in the wash-out quantitative features of BDA and BDC were evident.ConclusionThere is poor evidence that CEUS may be used to distinguish between different primary hepatobiliary neoplasms in cats.

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