Effect of oral isotretinoin on retinal nerve fibre layer and ganglion cell layer thickness

2021 ◽  
Vol 13 (01) ◽  
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Oral Isotretinoin ◽  
Nerve Fibre Layer

scholarly journals Retinal nerve fibre layer and ganglion cell layer changes in children who recovered from COVID-19: a cohort study

2021 ◽  
pp. archdischild-2021-321803
Author(s):  
Barbara Burgos-Blasco ◽  
Noemi Güemes-Villahoz ◽  
Laura Morales-Fernandez ◽  
Ignacio Callejas-Caballero ◽  
Pilar Perez-Garcia ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Thickness ◽  
Retinal Nerve Fibre Layer ◽  
Mean Difference ◽  
Fibre Layer ◽  
Nerve Fibre Layer

ObjectiveTo investigate the optic nerve and macular parameters of children who recovered from COVID-19 compared with healthy children using optical coherence tomography (OCT).DesignCohort study.SettingHospital Clinico San Carlos, Madrid.PatientsChildren between 6 and 18 years old who recovered from COVID-19 with laboratory-confirmed SARS-CoV-2 infection and historical controls were included.InterventionsAll patients underwent an ophthalmological examination, including macular and optic nerve OCT. Demographic data, medical history and COVID-19 symptoms were noted.Main outcome measuresPeripapillary retinal nerve fibre layer thickness, macular retinal nerve fibre layer thickness, macular ganglion cell layer thickness and retinal thickness.Results90 patients were included: 29 children who recovered from COVID-19 and 61 controls. Patients with COVID-19 presented an increase in global peripapillary retinal nerve fibre layer thickness (mean difference 7.7; 95% CI 3.4 to 12.1), temporal superior (mean difference 11.0; 95% CI 3.3 to 18.6), temporal inferior (mean difference 15.6; 95% CI 6.5 to 24.7) and nasal (mean difference 9.8; 95% CI 2.9 to 16.7) sectors. Macular retinal nerve fibre layer analysis showed decreased thickness in the nasal outer (p=0.011) and temporal inner (p=0.036) sectors in patients with COVID-19, while macular ganglion cell layer thickness increased in these sectors (p=0.001 and p=0.015, respectively). No differences in retinal thickness were noted.ConclusionsChildren with recent history of COVID-19 present significant changes in peripapillary and macular OCT analyses.

scholarly journals Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Metin Ekinci ◽  
Erdinç Ceylan ◽  
Halil Hüseyin Çağatay ◽  
Sadullah Keleş ◽  
Nergiz Hüseyinoğlu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Migraine With Aura ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Differences in macular pigment optical density across four ethnicities: a comparative study

2020 ◽  
Vol 12 ◽  
pp. 251584142092416
Author(s):  
Pinakin Gunvant Davey ◽  
Christopher Lievens ◽  
Stephanie Amonoo-Monney
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Optical Density ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Macular Pigment ◽  
Retinal Nerve Fibre Layer ◽  
Macular Pigment Optical Density ◽  
Nerve Fibre Layer

Objective: The aim of this study is to compare macular pigment optical density levels across four different ethnicities and study its influence on ganglion cell layer and retinal nerve fibre layer thickness across these ethnicities. Methods: Consenting adults visiting the ophthalmology and optometry clinics for a routine eye examination without any ocular comorbidity were enrolled. Participants underwent optical coherence tomography for macular thickness, retinal nerve fibre layer thickness and ganglion cell layer thickness. The macular pigment optical density levels were determined in the dominant eye using the QuantifEye device by trained observers. Results: In total, 336 eyes of 336 participants with a mean age of 39.2 ± 14.4 years were included of which 103 (30%) were Caucasians, 111 (33%) were African Americans, 29 (9%) were South Asian Indians and 94 (28%) were Hispanics. The mean macular pigment optical density value across the entire study population was 0.47 ± 0.15. South Asian Indians (0.58 ± 0.16) and Hispanics (0.52 ± 0.15) had significantly higher mean macular pigment optical density values compared with Caucasians (0.41 ± 0.16) and African Americans (0.38 ± 0.15). Linear regression analysis showed that there was a significant association between ethnicities and macular pigment optical density values when adjusted for age (β coefficient = 0.31, 95% confidence interval = 0.029–0.58, p < 0.001 for South Asian Indian and Hispanic ethnic groups compared with African Americans). There were no differences in the retinal nerve fibre layer and ganglion cell layer thickness across ethnic groups. Linear regression analysis also did not reveal any significant association between macular pigment optical density levels and retinal nerve fibre layer or ganglion cell layer thickness. Conclusion: Caucasians and African Americans have lower macular pigment optical density compared with South Asian Indians and Hispanics. There is no clinically significant association between macular pigment optical density levels and retinal nerve fibre layer and ganglion cell layer thickness in healthy individuals across races.

scholarly journals Spectral-domain OCT changes in retina and optic nerve in children with hypoxic–ischaemic encephalopathy

2020 ◽  
Author(s):  
L. Grego ◽  
S. Pignatto ◽  
E. Busolini ◽  
N. Rassu ◽  
F. Samassa ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Therapeutic Hypothermia ◽  
Nerve Fibre ◽  
Cerebral Oedema ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Abstract Purpose To evaluate the effect of neonatal hypoxic–ischaemic injury on the retina and the optic nerve and to correlate ocular damage with systemic parameters, laboratory tests, neurological imaging and therapeutic hypothermia at birth. Methods Forty-one children with hypoxic–ischaemic encephalopathy (HIE) at birth (9.09 ± 3.78 years) and a control group of 38 healthy subjects (9.57 ± 3.47 years) were enrolled in a cohort study. The HIE population was divided into three subgroups, based on the degree of encephalopathy according to Sarnat score and the treatment with therapeutic hypothermia (TH): Sarnat score I not treated with hypothermia, Sarnat score II-III treated with TH and Sarnat score II-III not subjected to TH. Total macular thickness, individual retinal layers and peripapillary nerve fibre layer thickness were measured with spectral-domain optical coherence tomography. Clinical data of perinatal period of HIE children were collected: APGAR score, pH and base excess of funiculus blood at birth, apnoea duration, brain ultrasound, cerebral MRI ischaemic lesions and blood chemistry tests. Results Children with Sarnat score I did not show a reduction of peripapillary nerve fibres and ganglion cell layer compared to the control group (p = 0.387, p = 0.316). Peripapillary nerve fibre layer was 109.06 ± 7.79 μm in children with Sarnat score II-III treated with TH, 108.31 ± 7.83 μm in subjects with Sarnat score II-III not subjected to TH and 114.27 ± 6.81 μm in the control group (p = 0.028, p = 0.007). Ganglion cell layer was thinner in children with Sarnat score II-III treated with TH (50.31 ± 5.13 μm) compared to the control group (54.04 ± 2.81 μm) (p = 0.01). Inner retinal layers damage correlated with C-reactive protein and lactate dehydrogenase increase, while higher levels of total bilirubin were protective against retinal impairment (p < 0.05). Cerebral oedema was related to peripapillary nerve fibre layer damage (p = 0.046). Conclusions Thickness reduction of inner retinal layer and peripapillary nerve fibre impairment was related to encephalopathy severity. Ocular damage was associated with inflammation and cerebral oedema following hypoxic–ischaemic damage.

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