Efficient Synthesis of α-Ferrocenyl Tertiary Alcohols Via CeCl3-Promoted Addition of Grignard Reagents to Large Hindered Ketones

2014 ◽  
Vol 38 (9) ◽  
pp. 546-548
Author(s):  
Haiying Zhao ◽  
Wenyao Zhang ◽  
Shufeng Chen ◽  
Zhanxi Bian
Keyword(s):  
Grignard Reagents ◽  
Efficient Synthesis ◽  
Tertiary Alcohols

scholarly journals Microwave-assisted Efficient Synthesis of Alliodorin and (±)-Curcuhydroquinone

1999 ◽  
Vol 23 (2) ◽  
pp. 164-165
Author(s):  
Goverdhan L. Kad ◽  
Anupam Khurana ◽  
Vasundhara Singh ◽  
Jasvinder Singh
Keyword(s):  
Grignard Reagents ◽  
Methyl Groups ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Microwave Assisted ◽  
Aryl Bromides ◽  
Key Steps

Terpenoids 1 and 2 have been synthesized from readily available starting materials using Li2CuCI4-catalysed coupling of Grignard reagents with alkyl/aryl bromides and microwave-assisted oxidation of allylic methyl groups, using SeO2/ButOOH adsorbed over SiO2 as key steps.

scholarly journals Copper-Catalyzed Asymmetric 1,2-Addition of Grignard Reagents to 3-Acyl 2H-chromenes

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2624-2628 ◽  
Author(s):  
Adriaan Minnaard ◽  
Beatriz Calvo
Keyword(s):  
Double Bond ◽  
Grignard Reagents ◽  
Tertiary Alcohols ◽  
Carbon Double Bond ◽  
High Yields

Enones in which the carbon–carbon double bond is part of the pharmacologically important 2H-chromene (2H-1-benzopyran) nucleus undergo asymmetric copper-catalyzed 1,2-addition of Grignard reagents. High yields and enantiomeric excesses up to 84% are obtained and access to these novel enantio-enriched tertiary alcohols is provided.

Sign in / Sign up

Export Citation Format

Share Document