scholarly journals Drug-Resistant Malaria Parasites Introduced into Madagascar from Comoros Islands

2007 ◽  
Vol 13 (11) ◽  
pp. 1759-1762 ◽  
Author(s):  
Didier Ménard ◽  
Armand Eugène Randrianarivo-Solofoniaina ◽  
Bedja Said Ahmed ◽  
Martial Jahevitra ◽  
Landy Valérie Andriantsoanirina ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Malaria Parasites

scholarly journals Prospects for the treatment of drug-resistant malaria parasites

2006 ◽  
Vol 1 (1) ◽  
pp. 127-141 ◽  
Author(s):  
Leann Tilley ◽  
Timothy ME Davis ◽  
Patrick G Bray
Keyword(s):  
Drug Resistant ◽  
Malaria Parasites

scholarly journals CHEMOTHERAPY, WITHIN-HOST ECOLOGY AND THE FITNESS OF DRUG-RESISTANT MALARIA PARASITES

Evolution ◽  
2010 ◽  
pp. no-no ◽  
Author(s):  
Silvie Huijben ◽  
William A. Nelson ◽  
Andrew R. Wargo ◽  
Derek G. Sim ◽  
Damien R. Drew ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Malaria Parasites ◽  
Host Ecology

PERSISTENCE OF DRUG-RESISTANT MALARIA PARASITES

The Lancet ◽  
1978 ◽  
Vol 311 (8057) ◽  
pp. 185-187 ◽  
Author(s):  
V.E. Rosario ◽  
D. Walliker ◽  
R. Hall ◽  
G.H. Beale
Keyword(s):  
Drug Resistant ◽  
Malaria Parasites

Drug-resistant malaria: where it occurs and how to avoid it

1975 ◽  
Vol 13 (13) ◽  
pp. 51-52
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Dihydrofolate Reductase ◽  
Parasite Species ◽  
Drug Resistant ◽  
Malaria Parasites ◽  
The Usa ◽  
Common Parasite

Drug resistance in the malaria parasites of man is of two kinds. The first is resistance to drugs which inhibit dihydrofolate reductase, proguanil (Paludrine) and pyrimethamine (Daraprim). This type occurs in all three common parasite species, Plasmodium falciparum, P. vivax and P. malariae. The second type of resistance is to the 4-aminoquinolines chloroquine and amodiaquine (Camoquin; Basoquin in the USA), and rarely to quinine, and this is known only in P. falciparum. Both types of resistance frequently coexist in falciparum infections.

scholarly journals Combination Therapy Counteracts the Enhanced Transmission of Drug-Resistant Malaria Parasites to Mosquitoes

2004 ◽  
Vol 48 (10) ◽  
pp. 3940-3943 ◽  
Author(s):  
Rachel L. Hallett ◽  
Colin J. Sutherland ◽  
Neal Alexander ◽  
Rosalynn Ord ◽  
Musa Jawara ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Selective Advantage ◽  
Treated Group ◽  
Sub Saharan Africa ◽  
Drug Resistant ◽  
Mosquito Vectors ◽  
Malaria Parasites ◽  
Enhanced Transmission ◽  
Sub Saharan ◽  
The Impact

ABSTRACT Malaria parasites carrying genes conferring resistance to antimalarials are thought to have a selective advantage which leads to higher rates of transmissibility from the drug-treated host. This is a likely mechanism for the increasing prevalence of parasites with resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine in sub-Saharan Africa. Combination therapy is the key strategy being implemented to reduce the impact of resistance, but its effect on the transmission of genetically resistant parasites from treated patients to mosquito vectors has not been measured directly. In a trial comparing CQ monotherapy to the combination CQ plus artesunate (AS) in Gambian children with uncomplicated falciparum malaria, we measured transmissibility by feeding Anopheles gambiae mosquitoes with blood from 43 gametocyte-positive patients through a membrane. In the CQ-treated group, gametocytes from patients carrying parasites with the CQ resistance-associated allele pfcrt-76T prior to treatment produced infected mosquitoes with 38 times higher Plasmodium falciparum oocyst burdens than mosquitoes fed on gametocytes from patients infected with sensitive parasites (P < 0.001). Gametocytes from parasites carrying the resistance-associated allele pfmdr1-86Y produced 14-fold higher oocyst burdens than gametocytes from patients infected with sensitive parasites (P = 0.011). However, parasites carrying either of these resistance-associated alleles pretreatment were not associated with higher mosquito oocyst burdens in the CQ-AS-treated group. Thus, combination therapy overcomes the transmission advantage enjoyed by drug-resistant parasites.

scholarly journals Origin of Robustness in Generating Drug-Resistant Malaria Parasites

2014 ◽  
Vol 31 (7) ◽  
pp. 1649-1660 ◽  
Author(s):  
Krittikorn Kümpornsin ◽  
Charin Modchang ◽  
Adina Heinberg ◽  
Eric H. Ekland ◽  
Piyaporn Jirawatcharadech ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Malaria Parasites
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