potential value
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2022 ◽  
pp. 0272989X2110728
Anna Heath ◽  
Petros Pechlivanoglou

Background Clinical care is moving from a “one size fits all” approach to a setting in which treatment decisions are based on individual treatment response, needs, preferences, and risk. Research into personalized treatment strategies aims to discover currently unknown markers that identify individuals who would benefit from treatments that are nonoptimal at the population level. Before investing in research to identify these markers, it is important to assess whether such research has the potential to generate value. Thus, this article aims to develop a framework to prioritize research into the development of new personalized treatment strategies by creating a set of measures that assess the value of personalizing care based on a set of unknown patient characteristics. Methods Generalizing ideas from the value of heterogeneity framework, we demonstrate 3 measures that assess the value of developing personalized treatment strategies. The first measure identifies the potential value of personalizing medicine within a given disease area. The next 2 measures highlight specific research priorities and subgroup structures that would lead to improved patient outcomes from the personalization of treatment decisions. Results We graphically present the 3 measures to perform sensitivity analyses around the key drivers of value, in particular, the correlation between the individual treatment benefits across the available treatment options. We illustrate these 3 measures using a previously published decision model and discuss how they can direct research in personalized medicine. Conclusion We discuss 3 measures that form the basis of a novel framework to prioritize research into novel personalized treatment strategies. Our novel framework ensures that research targets personalized treatment strategies that have high potential to improve patient outcomes and health system efficiency. Highlights It is important to undertake research prioritization before conducting any research that aims to discover novel methods (e.g., biomarkers) for personalizing treatment. The value of unexplained heterogeneity can highlight disease areas in which personalizing treatment can be valuable and determine key priorities within that area. These priorities can be determined under assumptions of the magnitude of the individual-level treatment effect, which we explore in sensitivity analyses.

Cosmetics ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 7
Antonietta Cerulli ◽  
Milena Masullo ◽  
Paola Montoro ◽  
Sonia Piacente

The interest in plant extracts and natural compounds in cosmetic formulations is growing. Natural products may significantly improve cosmetics performance since they have both cosmetic and therapeutic-like properties, known as cosmeceutical effects. Glycyrrhiza genus, belonging to the Leguminosae family, comprises more than 30 species, widely distributed worldwide. The rhizomes and roots are the most important medicinal parts currently used in pharmaceutical industries and in the production of functional foods and food supplements. In the last few years, the interest in their potential activities in cosmetic formulations has greatly increased. Glycyrrhiza spp. extracts are widely implemented in cosmetic products for their good whitening effect. The biological effects of Glycyrrhiza extracts are especially ascribable to the occurrence of specialized metabolites belonging to the flavonoid class. This review focuses on the botany and the chemistry of the main investigated Glycyrrhiza spp. (G. glabra, G. uralensis, and G. inflata) along with their cosmeceutical activities categorized as skin anti-aging, photoprotective, hair care, and anti-acne. It has been highlighted how, along with Glycyrrhiza extracts, three main flavonoids namely licochalcone A, glabridin, and dehydroglyasperin C are the most investigated compounds. It is noteworthy that other molecules from licorice show potential cosmeceutical effects. These data suggest further investigations to clarify their potential value for cosmetic industries.

2022 ◽  
pp. 371-396
Prasad Mandade ◽  
Edgard Gnansounou

2022 ◽  
Vol 961 (1) ◽  
pp. 012007
Hasan H Joni ◽  
Yassir K Hadi

Abstract Due to high temperatures and increased traffic loads, most of Iraq’s streets suffer from permanent distortion problems, especially in streets where there are checkpoints, therefore, there are needs for reports and researches specialized in improving the pavement layers and increasing their resistance to temperatures and high traffic loads to reduce the rut depth. In this research, the VESYS 5W program was used to find a potential value for rut depth, where ordinary asphalt mixes and improved asphalt mixes were used using SBS polymer at 4% by weight of asphalt were it is evaluated according to different properties of these mixture and the resilient modulus one of these properties for it is importance. The results showed that when the value of the resilient modulus increases, the rut depth decreases, as the rut depth was reduced by 42.5% for the surface layer and 73% for the base layer

2022 ◽  
pp. 43-72
Matteo Pio Prencipe ◽  
Behzad Maleki Vishkaei ◽  
Pietro De Giovanni

This chapter identifies the existing challenges in the winery industry and proposes to analyze their resolution by the adoption of blockchain technology. Blockchain allows the traceability of the whole process linked to wine production, from the cultivation of the grapes to the distribution of the bottles. Blockchain allows winery firms to unlock the potential value existing in some processes, especially when they create a competitive advantage. The chapter investigates these concepts within the case of Cantina Volpone, which has been the first case in Italy to adopt blockchain technology in the winery industry. This chapter studies the implementation path for blockchain technology in the winery industry and highlights the operational and financial challenges emerging from its adoption.

2021 ◽  
pp. 016224392110691
Erik Aarden

Biobanking in Singapore is characterized by contested relations between funding ambitions and research practices, and different notions of what the (potential) value of storing samples and data for medical research is. Different biobanking efforts anticipate the production of public goods from stored materials in specifically situated ways. These efforts to produce public goods in the form of scientific and economic value can be fruitfully understood in terms of extraction, a complex sociotechnical process of retrieving (potential) value from raw materials, which both informs and is informed by specific social values. In exploring the extraction of potential value in relation to practice values, I propose the notion of value formations to account for the coproduction of and intersections between different forms of value(s) in scientific practices situated in particular social contexts. I trace value formations across the life span of biobanking collections, which range from recruitment, collection, and processing of samples to their storage, retrieval, and use. Observations along this life span show the social and temporal complexity of value-making in biobanking in Singapore, pointing to the contextual specificity of how biobanking is understood as a public good.

2021 ◽  
Vol 4 (3) ◽  
pp. 5-14
K. A. Lukina ◽  
O. Y. Shoeva ◽  
O. N. Kovaleva ◽  
I. G. Loskutov

Background. Barley (Hordeum vulgare L.) and oat (Avena sativa L.) are grain crops belonging to one of the main sources of food and forage in the Russian Federation. They contain proteins, various groups of vitamins, fats, carbohydrates, β-glucans, minerals and different bioloactive compounds, including anthocyanins. Recently, much attention has been given to anthocyanins due to their various valuable properties. Therefore, the grain of barley and oat is a potentially promising economic product and a component of functional nutrition. The aim of this work was to estimate the content of anthocyanins in barley and oat accessions with different pigmentation of kernels and lemma. Materials and methods. 32 barley and 11 oat accessions were studied by spectrophotometry. Anthocyanins were extracted from barley and oat kernels with a 1% HCl solution in methanol. Results and discussion. As a result of the study, accessions and varieties with the highest content of anthocyanins were identified: for barley these are k-15904 (China), k-19906 (Mongolia), k-18709 (Japan), k-18723, k-18729 (Canada), k-17725 (Turkey) belonging to var. violaceum; k-29568 (Japan) – var. densoviolaceum; k-8690 (Ethiopia) – var. griseinigrum; k-28205 (Germany) – var. nudidubium; and for oat these are k-15527 (A. ayssinica Hochst. var. braunii Koern., Ethiopia) and k-15245 (A. strigosa Schreb. subsp. brevis var. tephera Mordv. ex Sold. et Rod., Poland). Conclusion. The obtained results demonstrated that the VIR collection includes accessions with potential value for the development of varieties with an increased anthocyanin content, which can be used as functional food products.

Yuyu GUO ◽  
Xueying ZHANG

LANGUAGE NOTE | Document text in Chinese; abstract also in English. This paper responds to “Emerging Human Embryo Research Technologies, the 14-Day Rule, and the Special Status of the Embryo” by analyzing the moral status of the embryo. We hold that the embryo has a limited moral status that is influenced by local ethical and cultural factors. The moral status of the embryo can be evaluated according to its potential value to and relationship with society within the specific ethical and cultural context. On whether the embryo should be used in research, we recommend that researchers follow the principle of permission, i.e., seek consent from the agents who best represent the interests of the embryo (usually the parents).

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