scholarly journals Purkinje Fiber

2020 ◽  
Author(s):  
Keyword(s):  

Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. S251-S252
Author(s):  
Tapan G. Rami ◽  
Stuart J. Beldner ◽  
Rupa Bala ◽  
Jonathan S. Sussman ◽  
William H. Sauer ◽  
...  


2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Su-Yi Tsai ◽  
Karen Maass ◽  
Jia Lu ◽  
Glenn I Fishman ◽  
Shuibing Chen ◽  
...  

Dysfunction of the cardiac conduction system (CCS) significantly impacts pathogenesis of arrhythmia, a major cause of morbidity and mortality. Strategies to derive cardiac conduction cells including Purkinje fiber cells (PC) would facilitate models for mechanistic studies and drug discovery, and also provide new cellular materials for regenerative therapies. A high-throughput chemical screen using CCS:lacZ and Contactin2:eGFP (Cntn2:eGFP) reporter embryonic stem cell (ESC) lines was used to discover a small molecule, sodium nitroprusside (SN), that efficiently promotes the generation of cardiac cells that express gene profiles and generate action potentials of PC-like cells. Imaging and mechanistic studies suggest that SN promotes the generation of PC from cardiac progenitors initially expressing cardiac myosin heavy chain, and that it does so by activating cAMP signaling. These findings provide a novel strategy to derive scalable PC, along with insight into the ontogeny of CCS development.



Author(s):  
Takashi Mikawa ◽  
Robert G. Gourdie ◽  
Clifton P. Poma ◽  
Maxim Shulimovich ◽  
Christopher Hall ◽  
...  
Keyword(s):  


Neonatology ◽  
1994 ◽  
Vol 66 (6) ◽  
pp. 330-338
Author(s):  
Christopher L. Case ◽  
Kenneth W. Hewett ◽  
Paul C. Gillette


1985 ◽  
Vol 249 (1) ◽  
pp. H108-H121
Author(s):  
J. M. Jaeger ◽  
W. R. Gibbons

Two outward currents, IX1 and IX2, are thought to be activated by depolarization of the Purkinje fiber. One of these, IX1, is presently believed to play a critical role in repolarization of the action potential. The IX currents were originally analyzed in voltage-clamp experiments in sheep Purkinje fibers. These experiments were designed to minimize interference by other currents, and it was assumed that changes of the net current were produced entirely by the IX currents. We have tried to repeat the original experiments and the analysis that led to acceptance of the existence and roles of the IX currents, without success. Moreover, tests of how membrane current should behave if the IX current hypothesis is correct did not give satisfactory results. Our data suggest the original conclusions about IX1 and IX2 may need substantial revision.



1984 ◽  
Vol 7 (2) ◽  
pp. 94-108 ◽  
Author(s):  
Robert F. Reder ◽  
Peter Danilo, Jr. ◽  
Michael R. Rosen


1973 ◽  
Vol 32 (3) ◽  
pp. 377-384 ◽  
Author(s):  
PERRY M. HOGAN ◽  
STEPHEN M. WITTENBERG ◽  
FRANCIS J. KLOCKE


1984 ◽  
Vol 46 (6) ◽  
pp. 937-940
Author(s):  
Takayuki MURAKAMI ◽  
Gotaro TANAKA ◽  
Tetsuo NASU ◽  
Isao SAITO ◽  
Koshi MOCHIZUKI
Keyword(s):  


1994 ◽  
Vol 75 (3) ◽  
pp. 511-519 ◽  
Author(s):  
T M Munger ◽  
S B Johnson ◽  
D L Packer


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