scholarly journals Purkinje Fiber

2020 ◽  
Author(s):  
Keyword(s):  
Purkinje Fiber

Purkinje fiber trigger for ventricular tachycardia: Local exit block with ablation leading to change in QRS morphology and difficulty with mapping

Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. S251-S252
Author(s):  
Tapan G. Rami ◽  
Stuart J. Beldner ◽  
Rupa Bala ◽  
Jonathan S. Sussman ◽  
William H. Sauer ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Purkinje Fiber ◽  
Qrs Morphology ◽  
Exit Block

Abstract 304: Efficient Generation of Cardiac Purkinje Fiber-like Cells From ESCs by Activating cAMP Signaling

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Su-Yi Tsai ◽  
Karen Maass ◽  
Jia Lu ◽  
Glenn I Fishman ◽  
Shuibing Chen ◽  
...  
Keyword(s):  
Embryonic Stem ◽  
Cardiac Cells ◽  
Cardiac Conduction ◽  
Camp Signaling ◽  
Purkinje Fiber ◽  
Mechanistic Studies ◽  
Cardiac Progenitors ◽  
Gene Profiles ◽  
Novel Strategy ◽  
Regenerative Therapies

Dysfunction of the cardiac conduction system (CCS) significantly impacts pathogenesis of arrhythmia, a major cause of morbidity and mortality. Strategies to derive cardiac conduction cells including Purkinje fiber cells (PC) would facilitate models for mechanistic studies and drug discovery, and also provide new cellular materials for regenerative therapies. A high-throughput chemical screen using CCS:lacZ and Contactin2:eGFP (Cntn2:eGFP) reporter embryonic stem cell (ESC) lines was used to discover a small molecule, sodium nitroprusside (SN), that efficiently promotes the generation of cardiac cells that express gene profiles and generate action potentials of PC-like cells. Imaging and mechanistic studies suggest that SN promotes the generation of PC from cardiac progenitors initially expressing cardiac myosin heavy chain, and that it does so by activating cAMP signaling. These findings provide a novel strategy to derive scalable PC, along with insight into the ontogeny of CCS development.

Induction and Patterning of the Impulse Conducting Purkinje Fiber Network

2007 ◽  
pp. 91-94
Author(s):  
Takashi Mikawa ◽  
Robert G. Gourdie ◽  
Clifton P. Poma ◽  
Maxim Shulimovich ◽  
Christopher Hall ◽  
...  
Keyword(s):  
Purkinje Fiber ◽  
Fiber Network

Developmental Electrophysiology of Encainide and Its Major Metabolites on the Purkinje Fiber Action Potential

Neonatology ◽  
1994 ◽  
Vol 66 (6) ◽  
pp. 330-338
Author(s):  
Christopher L. Case ◽  
Kenneth W. Hewett ◽  
Paul C. Gillette
Keyword(s):  
Action Potential ◽  
Purkinje Fiber ◽  
Fiber Action

A re-examination of late outward plateau currents of cardiac Purkinje fibers

1985 ◽  
Vol 249 (1) ◽  
pp. H108-H121
Author(s):  
J. M. Jaeger ◽  
W. R. Gibbons
Keyword(s):  
Action Potential ◽  
Voltage Clamp ◽  
Critical Role ◽  
Membrane Current ◽  
Purkinje Fiber ◽  
Purkinje Fibers ◽  
Outward Currents ◽  
Cardiac Purkinje Fibers

Two outward currents, IX1 and IX2, are thought to be activated by depolarization of the Purkinje fiber. One of these, IX1, is presently believed to play a critical role in repolarization of the action potential. The IX currents were originally analyzed in voltage-clamp experiments in sheep Purkinje fibers. These experiments were designed to minimize interference by other currents, and it was assumed that changes of the net current were produced entirely by the IX currents. We have tried to repeat the original experiments and the analysis that led to acceptance of the existence and roles of the IX currents, without success. Moreover, tests of how membrane current should behave if the IX current hypothesis is correct did not give satisfactory results. Our data suggest the original conclusions about IX1 and IX2 may need substantial revision.

Developmental Changes in Alpha Adrenergic Effects on Canine Purkinje Fiber Automaticity

1984 ◽  
Vol 7 (2) ◽  
pp. 94-108 ◽  
Author(s):  
Robert F. Reder ◽  
Peter Danilo, Jr. ◽  
Michael R. Rosen
Keyword(s):  
Developmental Changes ◽  
Purkinje Fiber ◽  
Adrenergic Effects

scholarly journals Relationship of Stimulation Frequency to Automaticity in the Canine Purkinje Fiber during Ouabain Administration

1973 ◽  
Vol 32 (3) ◽  
pp. 377-384 ◽  
Author(s):  
PERRY M. HOGAN ◽  
STEPHEN M. WITTENBERG ◽  
FRANCIS J. KLOCKE
Keyword(s):  
Stimulation Frequency ◽  
Purkinje Fiber ◽  
Relationship Of

scholarly journals The subendocardial purkinje fiber of the duck.

1984 ◽  
Vol 46 (6) ◽  
pp. 937-940
Author(s):  
Takayuki MURAKAMI ◽  
Gotaro TANAKA ◽  
Tetsuo NASU ◽  
Isao SAITO ◽  
Koshi MOCHIZUKI
Keyword(s):  
Purkinje Fiber

scholarly journals Voltage dependence of beta-adrenergic modulation of conduction in the canine Purkinje fiber.

1994 ◽  
Vol 75 (3) ◽  
pp. 511-519 ◽  
Author(s):  
T M Munger ◽  
S B Johnson ◽  
D L Packer
Keyword(s):  
Voltage Dependence ◽  
Purkinje Fiber ◽  
Beta Adrenergic ◽  
Adrenergic Modulation
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