scholarly journals MATURE TESTICULAR TERATOMA IN PEDIATRIC PATIENT: A CASE REPORT

2022 ◽  
Vol 29 (1) ◽  
Author(s):  
Gugum Indra Firdaus ◽  
Jufriady Ismy
Keyword(s):  
Pediatric Patient ◽  
Histopathological Examination ◽  
Germ Cell Tumors ◽  
Vital Signs ◽  
Imaging Study ◽  
Current Therapy ◽  
Testicular Germ Cell ◽  
Left Testis ◽  
Paraaortic Lymph Nodes ◽  
Radical Orchiectomy

Objective: To report our experience on management of testicular teratoma in pediatric patient. Case(s) presentation: A 2-years-old boy presented with progressive mass in his left testis. The mass was found 3 months ago but became larger in a few days. The patient had no other genitourinary complaint. Vital signs were within normal limits. A hard and tender mass in the left scrotum sized 5x4x2.5 cm was palpated from the physical examination. An imaging study with Computed Tomography (CT) Scan revealed an enhancement in the left scrotum mass area. There was no ring enhancement in pelvic and paraaortic lymph nodes. The laboratory examination within normal limit. Inguinal radical orchiectomy was performed, and histopathological examination revealed a mature testicular teratoma of the left testis. Discussion: Testicular teratoma in children is usually benign. Testicular germ cell tumors generally have a good prognosis with current therapy. Post-orchiectomy management depends on the histology type, staging, and tumor markers. Conclusion: Testicular teratoma is a rare case and can cause minimal symptoms until it grows significantly. Testicular teratoma should be considered in the differential diagnosis of non-traumatic painless progressive scrotal mass. Inguinal radical orchiectomy may be considered as the primary management.

scholarly journals Burned-Out Testicular Cancer: Really a Different History

2017 ◽  
Vol 10 (3) ◽  
pp. 846-850 ◽  
Author(s):  
Claudia Mosillo ◽  
Simone Scagnoli ◽  
Giulia Pomati ◽  
Salvatore Caponnetto ◽  
Maria Laura Mancini ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Histopathological Examination ◽  
Mature Teratoma ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Testicular Germ Cell ◽  
Abdominal Lymph Node ◽  
Cell Components ◽  
Histological Regression

Two or more histological types characterize more than 60% of testicular germ cell tumors (GCTs). Burned-out testicular tumor refers to partial or complete histological regression of the primary testicular lesions. The most frequent GCT type involved in this kind of histological regression is choriocarcinoma, followed by embryonal carcinoma. To our knowledge, there are no cases of the burned-out phenomenon in teratoma. We report a case of a 19-year-old man presenting to our institute with a right testicular lesion, evidence of mediastinal and abdominal lymph node metastasis, and high levels of GCT serum biomarkers. After orchiectomy, the histopathological examination showed a mixed GCT: mature teratoma, immature teratoma, and histological features of testicular cancer regression (burned-out phenomenon). The patient underwent first-line chemotherapy (BEP regimen) which resulted in a complete instrumental and biochemical response after 4 cycles. Teratoma is considered a less aggressive type of GCT. In this particular case, metastatic disease seems to result from non-germ cell components which underwent early spontaneous regression.

scholarly journals Bilateral synchronous testicular seminoma: A rare presentation of a rare disease

2018 ◽  
Vol 90 (1) ◽  
pp. 68
Author(s):  
Pedro Simões De Oliveira ◽  
Tiago Ribeiro De Oliveira ◽  
Sérgio Pereira ◽  
David Martinho ◽  
Tomé Lopes
Keyword(s):  
Rare Disease ◽  
Frozen Section ◽  
Clinical Stage ◽  
Survival Rates ◽  
Germ Cell Tumors ◽  
Young Male ◽  
Rare Presentation ◽  
Testicular Germ Cell ◽  
Testicular Seminoma ◽  
Radical Orchiectomy

Objective: To present a case of a bilateral synchronous testicular seminoma in a young male clinical stage IIB. Material and method: A 37 years old man presented a bilateral testicular mass with elevated tumoral markers. Histology of frozen section revealed bilateral seminoma and bilateral radical orchiectomy was performed. Result: Enhanced chest and abdominopelvic staging CT scan revealed a lymphadenopathy of 30 mm within the inter-aortocava nodal chain (stage IIB). Patient received three cycles of BEP. Three months later 18F-FDG PET showed no evidence of hypermetabolic activity and serum tumoral markers were normal. Conclusion: Bilateral testicular germ cell tumors are a rare disease. Management of this tumors is controversial. Bilateral radical orchiectomy is the standard of care, nevertheless, in order to preserve fertility and androgen production, an organsparing surgery can be attempted in selected cases. Although prognosis is good, with overall survival rates similar to patients with unilateral disease, life-long close follow-up may be advocated due to relapse risk.

Synchronous bilateral testicular cancer with discordant histopathology occurring in a 20-year-old patient: A case report and review of the literature

2021 ◽  
pp. 039156032110285
Author(s):  
Evangelos N Symeonidis ◽  
Ioannis Tsifountoudis ◽  
Anastasios Anastasiadis ◽  
Wilbert F Mutomba ◽  
Rodoula Kotakidou ◽  
...  
Keyword(s):  
Germ Cell ◽  
Embryonal Carcinoma ◽  
Germ Cell Tumors ◽  
Testicular Sperm Extraction ◽  
Testosterone Replacement Therapy ◽  
Testicular Germ Cell ◽  
Left Testis ◽  
Mixed Germ Cell Tumor ◽  
The Right ◽  
Enhanced Computed Tomography

Introduction: Bilateral testicular tumors are very rare, accounting for 1%–5% of all testicular germ-cell tumors (TGCTs). The vast majority of primary bilateral TGCTs are metachronous, with synchronous tumors comprising approximately 0.5%–1% of all cases. Those occurring synchronously share mostly the same histological pattern, predominantly seminoma, with synchronous bilateral TGCTs (SBTGCTs) with discordant subtypes being extremely rare. Case presentation: We present the case of a 20-year-old male complaining of a palpable painless right testicular mass incidentally noticed during sexual intercourse. Ultrasonography (US) and magnetic resonance imaging (MRI) of the scrotum demonstrated bilateral testicular lesions, while staging with contrast-enhanced computed tomography (CT) exhibited normal findings. Right radical orchiectomy and left testis-sparing surgery (TSS) with concomitant onco-testicular sperm extraction (onco-TESE) were initially performed. Histology of the right testis revealed a mixed germ-cell tumor, consisting of seminoma and embryonal carcinoma, while that from the left testis disclosed embryonal carcinoma and intratubular germ-cell neoplasia unclassified (IGCNU) infiltrating the surgical margins. Hence, left orchiectomy was subsequently scheduled with histology unveiling IGCNU in the greatest part of the remaining testicular parenchyma. Following adjuvant chemotherapy, with bleomycin, etoposide, and cisplatin (BEP), the patient received testosterone replacement therapy and remained free of recurrence at an 18-month follow-up. Conclusion: This case highlights both the rarity of a bilateral testicular tumor’s synchronous appearance and its extremely infrequent discordant histopathology. A comprehensive review of the major series of SBTGCTs with discordant histology cited in the literature is additionally presented.

scholarly journals Discrepancy in pathology reports upon second review of radical orchiectomy specimens for testicular germ cell tumors

2020 ◽  
Vol 14 (12) ◽  
Author(s):  
Gregory J. Nason ◽  
Joan Sweet ◽  
Lauren Landoni ◽  
Ricardo Leao ◽  
Lynn Anson-Cartwright ◽  
...  
Keyword(s):  
Germ Cell ◽  
Spermatic Cord ◽  
Tumor Staging ◽  
Germ Cell Tumors ◽  
Surgical Margin ◽  
Pathology Report ◽  
Histological Subtype ◽  
Testicular Germ Cell ◽  
Radical Orchiectomy ◽  
Pathology Review

Introduction: We sought to evaluate the discrepancies between primary pathology report and second pathology review of radical orchiectomy (RO) specimens. Methods: A retrospective review was performed of RO specimens from the Ontario Cancer Registry. All cases required both a primary pathology report and a second pathology review from another institution. Histopathological variables assessed included histological subtype and components of mixed germ cell tumor (GCT), pathological tumor (pT) stage, lymphovascular invasion (LVI), spermatic cord invasion, and surgical margin. Results: Between 1994 and 2015, 5048 ROs were performed with 2719 (53.9%) seminoma and 2029 (40.2%) non-seminoma. Of these, 519 (10.3%) received a second pathology review. There was concordance between primary pathology report and second pathology review in 326 (62.8%) cases. The most common discrepancies involved a change in pT stage (n=148, 28.5%), with upstaging in 83 (16%) and downstaging in 65 (12.5%) cases relative to the original pT stage. The second most common discrepancy regarded the reporting of LVI (n=121, 23.3%), with 62 (11.9%) reporting presence of LVI when the primary pathology report did not. Other discrepancies included a change in the histological subtype in 28 (5.4%) cases and spermatic cord margin status in 5 (9.6%) cases. Conclusions: Only 10% of orchiectomy specimens underwent a second pathology review, with nearly 40% of reviews leading to a meaningful change in parameters. Such variation could lead to incorrect tumor staging, estimate of relapse risk, and inappropriate treatment decisions. Expert pathology review of RO specimens should be considered, as it has significant implications for decision making.

scholarly journals Fertility preservation in non-seminomatous germ cell tumor: a case report

2021 ◽  
Vol 10 (3) ◽  
pp. 1192
Author(s):  
Nayana Patel ◽  
Niket Patel ◽  
Molina Patel ◽  
Yuvraj Jadeja ◽  
Harsha Bhadarka ◽  
...  
Keyword(s):  
Germ Cell ◽  
Fertility Preservation ◽  
Survival Rates ◽  
Germ Cell Tumors ◽  
Good Survival ◽  
High Survival ◽  
Testicular Germ Cell ◽  
Left Testis ◽  
Fertility Awareness ◽  
Common Malignancy

Testicular germ cell tumors (TGCTs) are the most common malignancy in young men in their peak fertility years. It can intrinsically and permanently affect fertility potential of an individual. Clinicians are advised to offer Fertility Preservation before initiating the treatment. We present one such case of presence of Neoplasm in testis, where semen was cryopreserved before operating it for fertility preservation and biological pregnancy was achieved. On further investigations, presence of neoplasm on left testis was diagnosed. However, neoplasms of the testes are unique in that way they affect men at a young age and also have a high survival rates. Cryopreservation of ejaculated or surgically retrieved sperm is currently the only established method of fertility preservation for post-pubertal man. The incidence as well as rates for testicular cancers have remained relatively low and if presented early on, can be cured and has good survival rates. Fertility awareness must be raised amongst the oncologist, gynecologist and patients.

PD19-08 DISCREPANCY IN PATHOLOGY REPORTS UPON SECOND REVIEW OF RADICAL ORCHIECTOMY SPECIMENS FOR TESTICULAR GERM CELL TUMORS

2020 ◽  
Vol 203 ◽  
pp. e385
Author(s):  
Gregory Nason* ◽  
Lauren Landoni ◽  
Spencer Mok ◽  
Lynn Anson-Cartwright ◽  
Padraig Warde ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Radical Orchiectomy ◽  
Pathology Reports

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

Recent Advances in New Discovered Molecular Targets in Testicular Germ Cell Tumors

2018 ◽  
Vol 25 (5) ◽  
pp. 575-583 ◽  
Author(s):  
Paolo Chieffi
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cells ◽  
Germ Cell Tumors ◽  
Molecular Targets ◽  
Testicular Germ Cell Tumor ◽  
Research Literature ◽  
Testicular Germ Cell ◽  
Solid Malignancy ◽  
Bibliographic Data ◽  
New Biomarkers

Background: Testicular germ cell tumor (TGCT) is the most common solid malignancy occurring in young men between 20 and 34 years of age, and its incidence has increased significantly over the last decades. TGCTs can be subdivided into seminoma and nonseminoma germ cell tumors (NSGCTs), which includes yolk sac tumor, choriocarcinoma, embryonal cell carcinoma, and teratoma. Seminomas and NSGCTs present significant differences in therapy, prognosis, and both show characteristics of the Primordial Germ Cells (PGCs). Methods: I undertook a search of bibliographic data from peer-reviewed research literature. Results: Seventy papers were included in the mini-review showing that a large number of new biomarkers have given further advantages to discriminate the different histotypes and could represent useful novel molecular targets for anticancer strategies. Conclusion: A deeper understanding of the pathogenesis of TGCTs is likely to significantly improve not only our knowledge on stem cells and oncogenesis but also the disease management with more selective tumor treatment.

Sign in / Sign up

Export Citation Format

Share Document