Role of calcium channel blocker in excessive mast cell degranulation

Here, I present a case of a female patient, age 45 years, for whom the uncontrolled mast cell degranulation created many issues related to allergy like, skin rash, itching, breathing discomfort, frequent throat infection, GERD, migraine, fibromyalgia, peripheral neuropathy, depression, anxiety disorder, constipation etc. For the patient, it was observed that calcium channel blockers seem to control the unnecessary and uncontrolled mast cell degranulation. CCB seemed to have a role to play in mast cell degranulation.

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Role of calcium channel blocker in excessive mast cell degranulation

10.21203/rs.3.rs-632517/v1 ◽

2021 ◽

Author(s):

Sagarika Datta

Keyword(s):

Mast Cell ◽

Calcium Channel ◽

Channel Blocker ◽

Mast Cell Degranulation ◽

Channel Blockers ◽

Case Presentation ◽

H2 Blocker ◽

Throat Infection ◽

Stomach Acid

Abstract Background:I present a case of a female patient, age 45 years, for whom the uncontrolled mast cell degranulation created many issues related to allergy like, skin rash, itching, breathing discomfort, frequent throat infection, GERD, migraine, fibromyalgia, peripheral neuropathy, depression, anxiety disorder, constipation etc. For the patient, it was observed that calcium channel blockers seem to control the unnecessary and uncontrolled mast cell degranulation. CCB seemed to have a role to play in mast cell degranulation.Case presentation:When the patient is taking either Flunarizine or Pregabalin or both together, the need for antihistamine and montelukast are very low. The patient suffers less throat infection while Flunarizine or Pregabalin are being taken. More the dose of Pregabalin less the occurrence of any type of allergy (food, pollen, dust etc.). The requirement of corticosteroid inhaler for breathing discomfort is also less. Frequency of body pain, migraine is minimal. Occurrence of stomach acid or GERD or digestion disorder is also very less. In terms of mood or anxiety, body is stable too. So, per day when 3 Pregabalin (75mg) were taken with 1 Amitriptyline (50mg) and 1 Duloxetine (60mg) health is completely stable with no need for H1 Blocker, H2 Blocker, Montelukast and Corticosteroid inhaler. Conclusion:CCB, specifically L-type CCB must have role in controlling the degranulation of mast cells, thus reducing all problem together at the root. But there are disadvantages like aggravated IBS (lazy gut), aggravated RLS and fluid retention (swelling of palm).We must check the use of Gabapentin and Sodium cromoglycate too. They should also control the unnecessary mast cell degranulation. Thus, fixing the problem at the root.

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Electroanalytical Methods for Determination of Calcium Channel Blockers

Current Analytical Chemistry ◽

10.2174/1573411014666180426165750 ◽

2019 ◽

Vol 15 (3) ◽

pp. 207-218 ◽

Cited By ~ 1

Author(s):

Fatma Ağın

Keyword(s):

Calcium Channel ◽

Calcium Channel Blockers ◽

Channel Blocker ◽

Heart Diseases ◽

Dosage Forms ◽

Channel Blockers ◽

Electroanalytical Methods ◽

Pharmaceutical Dosage Forms ◽

Ischemic Heart Diseases

Background:Calcium Channel Blockers (CCBs) are widely used in the treatment of cardiovascular and ischemic heart diseases in recent years. They treat arrhythmias by reducing cardiac cycle contraction and also benefit ischemic heart diseases. Electroanalytical methods are very powerful analytical methods used in the pharmaceutical industry because of the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations (10-50 ng/ml). The purpose of this review is to gather electroanalytical methods used for the determination of calcium channel blocker drugs in pharmaceutical dosage forms and biological media selected mainly from current articles.Methods:This review mainly includes recent determination studies of calcium channel blockers by electroanalytical methods from pharmaceutical dosage forms and biological samples. The studies of calcium channel blockers electroanalytical determination in the literature were reviewed and interpreted.Results:There are a lot of studies on amlodipine and nifedipine, but the number of studies on benidipine, cilnidipine, felodipine, isradipine, lercanidipine, lacidipine, levamlodipine, manidipine, nicardipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, diltiazem, and verapamil are limited in the literature. In these studies, DPV and SWV are the most used methods. The other methods were used less for the determination of calcium channel blocker drugs.Conclusion:Electroanalytical methods especially voltammetric methods supply reproducible and reliable results for the analysis of the analyte. These methods are simple, more sensitive, rapid and inexpensive compared to the usually used spectroscopic and chromatographic methods.

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