scholarly journals Extramedullary relapse of acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcomes

Haematologica ◽  
2012 ◽  
Vol 98 (2) ◽  
pp. 179-184 ◽  
Author(s):  
A. C. Harris ◽  
C. L. Kitko ◽  
D. R. Couriel ◽  
T. M. Braun ◽  
S. W. Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Myeloid Leukemia ◽  
Hematopoietic Stem ◽  
Extramedullary Relapse ◽  
Incidence Risk ◽  
Acute Myeloid

scholarly journals Cardiac Relapse of Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
María Facenda-Lorenzo ◽  
Ana Sánchez-Quintana ◽  
Alejandro Quijada-Fumero ◽  
Ana Laynez-Carnicero ◽  
Joaquín Breña-Atienza ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Myeloid Leukemia ◽  
Cardiac Tumors ◽  
Hematopoietic Stem ◽  
Extramedullary Relapse ◽  
Acute Myeloid

Secondary or metastatic cardiac tumors are much more common than primary benign or malignant cardiac tumors. Any tumor can cause myocardial or pericardial metastasis, although isolated or combined tumor invasion of the pericardium is more common. Types of neoplasia with the highest rates of cardiac or pericardial involvement are melanoma, lung cancer, and breast and mediastinal carcinomas. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Initial treatment involves chemotherapy followed by consolidation treatment to reduce the risk of relapse. In high-risk patients, the treatment of choice for consolidation is hematopoietic stem cell transplantation (HSCT). Relapse of AML is the most common cause of HSCT failure. Extramedullary relapse is rare. The organs most frequently affected, called “sanctuaries,” are the testes, ovaries, and central nervous system. We present a case with extramedullary relapse in the form of a solid cardiac mass.

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