scholarly journals Effects of Ganoderma Lucidum Extract on Morphine-Induced Addiction and Memory Impairment in Mice

2021 ◽  
Vol 12 (1) ◽  
pp. 1076-1084

Ganoderma lucidum extract (Lingzhi) has been used so far with various pharmacological effects. However, the reports on its effects on drug addiction, especially morphine, and morphine-induced memory impairment in vivo, remain limited. In the present study, the effect of G. lucidum extracts on preventing morphine addiction was evaluated by the conditioned place preference model. The extract's learning and memory improvement activities on morphine-induced memory loss were examined using Y maze, novel recognition, and Morris water maze tests. The results found that G. lucidum extracts at doses of 200-400 mg/kg decreased conditioned place preference score and increased the percentage of alteration, novel object exploration, and prolongation of locating hidden platform. With these doses, G. lucidum extracts prevented morphine addiction and improved short-term memory, visual memory, and long-term memory impairment caused by morphine. Our results first demonstrated that G. lucidum extracts promised as an effective natural source in treating drug addiction and morphine-induced memory loss.

2006 ◽  
Vol 26 (8) ◽  
pp. 1190-1192 ◽  
Author(s):  
Laura Galatti ◽  
Giovanni Polimeni ◽  
Francesco Salvo ◽  
Marcello Romani ◽  
Aurelio Sessa ◽  
...  

2021 ◽  
Vol 89 (6) ◽  
pp. 897-902
Author(s):  
EMAN F. EL-WAKIL, M.D.; RASHA M. SHOEIB, M.D. ◽  
YOSSRA A.N. SALLAM, M.D.; MAHA H. BOSHNAQ, M.D.

2018 ◽  
Vol 33 (6) ◽  
pp. 1923-1934 ◽  
Author(s):  
Mohammed Nuru ◽  
Nino Muradashvili ◽  
Anuradha Kalani ◽  
David Lominadze ◽  
Neetu Tyagi

2018 ◽  
Vol 13 (3) ◽  
pp. 417-431 ◽  
Author(s):  
Laura Smith ◽  
David Wilkinson ◽  
Mayur Bodani ◽  
Rowena Bicknell ◽  
S. S. Surenthiran

2021 ◽  
Vol 14 (1) ◽  
pp. e237398
Author(s):  
Jonathan E Attwood ◽  
Saniya Naseer ◽  
Sophia Michael ◽  
Josie Riley

An 83-year-old woman was referred to hospital with a 2-week history of short-lived episodic unpleasant sensations in her head and running down her body. This was accompanied by new short-term memory impairment and arm spasms. Initial investigations including blood tests and brain imaging did not reveal the diagnosis. The patient developed an increasing frequency of abnormal movements of her face and arm. These were clinically recognised as faciobrachial dystonic seizures (FBDS). FBDS are pathognomonic of an autoimmune encephalitis caused by an antibody directed against leucine-rich glioma-inactivated 1 (LGI1). The clinical diagnosis resulted in treatment with immunotherapy, leading to cessation of seizures and rapid cognitive recovery. Later, the predicted serology was confirmed. This reversible and under-recognised cause of cognitive impairment, typically affecting elderly patients, can be diagnosed clinically to enable early and effective treatment.


Sign in / Sign up

Export Citation Format

Share Document