Distal Renal Tubular Acidosis Associated with Mixed Connective Tissue Disease and Hypothyroidism

2018 ◽  
Vol 30 (2) ◽  
pp. 76-78
Author(s):  
Razib Kumar Saha ◽  
Md Azizul Haque ◽  
Mohammad Hasan Tarik
Keyword(s):  
Rheumatoid Arthritis ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Renal Tubular Acidosis ◽  
Lupus Erythematosus ◽  
Mixed Connective Tissue Disease ◽  
Distal Renal Tubular Acidosis ◽  
Acid Transport ◽  
Systemic Lupus ◽  
Renal Tubular

Renal tubular acidosis (RTA) is caused by defect in renal tubular acid transport. Sjogren’s syndrome, rheumatoid arthritis, systemic lupus erythematosus and autoimmune hepatitis are the most common autoimmune causes of distal RTA. We are reporting a case of distal renal tubular acidosis associated with mixed connective tissue disease and hypothyroidism presenting as recurrent hypokalemic paralysis.TAJ 2017; 30(2): 76-78

scholarly journals Proteasome alpha-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus.

1996 ◽  
Vol 184 (4) ◽  
pp. 1313-1318 ◽  
Author(s):  
E Feist ◽  
T Dörner ◽  
U Kuckelkorn ◽  
G Schmidtke ◽  
B Micheel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Lupus Erythematosus ◽  
Mixed Connective Tissue Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
20S Proteasome ◽  
Systemic Lupus ◽  
Alpha Type

Autoantibodies occur in low frequencies among patients with myositis characterizing only distinct subsets of this disease. Most of these known antibodies are directed to enzymatically active complexes. The 20S proteasome represents an essential cytoplasmatic protein complex for intracellular nonlysosomal protein degradation, and is involved in major histocompatibility complex class I restricted antigen processing. In this study we investigated whether the 20S proteasome complex is an antibody target in myositis and in other autoimmune diseases. 34 sera of poly/dermatomyositis patients were assayed for antiproteasomal antibodies using enzyme-linked immunosorbent assay, immunoblot, and two-dimensional non-equilibrium pH gradient electrophoresis (NEPHGE). Sera was from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease, and rheumatoid arthritis; healthy volunteers served as controls. In 62% (21/34) of the cases sera from patients with myositis and in 58% (30/52) of the cases sera from patients with SLE reacted with the 20S proteasome. These frequencies exceeded those of sera from patients with mixed connective tissue disease, rheumatoid arthritis, and healthy controls. The alpha-type subunit C9 of the 20S proteasome was determined to be the predominant target of the autoimmune sera in myositis and SLE. Lacking other frequent autoantibodies in myositis, the antiproteasome antibodies are the most common humoral immune response so far detected in this disease entity.

Mixed Connective Tissue Disease- Physician’s Dilemma: A case report

2021 ◽  
Vol 11 (Number 1) ◽  
pp. 60-65
Author(s):  
Abu Saleh Shimon ◽  
Mahjuba Umme Salam ◽  
Monharul Islam Bhuiyan ◽  
Mashuq Ahmad Jumma ◽  
Imran Hussain ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Lupus Erythematosus ◽  
Mixed Connective Tissue Disease ◽  
High Titer ◽  
Connective Tissue Diseases ◽  
Systemic Lupus ◽  
Serological Tests ◽  
Normotensive Woman ◽  
New Onset

Mixed connective tissue disease is an entity of autoimmune disease with overlapping features of systemic lupus erythematosus, scleroderma, rheumatoid arthritis, dermatomyositis and with positive anti-U1 RNP antibody. We report here a 52 year old non-diabetic, normotensive woman presenting with new onset dysphagia for two months with variable features of multiple types of connective tissue diseases for two years. Clinical features and type specific serological tests for different connective tissue diseases showed puzzling results. However, finally a high titer of anti-U1RNP antibody led to the diagnosis of mixed connective tissue disease.

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