Vertebrogenous syndrome, lumbosacral spine against the backdrop of connective tissue dysplasia in athletes

2018 ◽  
pp. 27-31
Author(s):  
A. Pyantkovsky
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Postnatal Period ◽  
Tissue Homeostasis ◽  
Lumbosacral Spine ◽  
Duration Of Treatment ◽  
Disc Protrusion ◽  
Anatomical Changes ◽  
Connective Tissue Dysplasia ◽  
Pain Analysis

In Ukraine, according to WHO, the disease of the spine is the fourth after cardiovascular system, oncology and pathology of diabetes. Dysplasia of connective tissue (DST) - a violation of the structure of the connective tissue in the embryonic and postnatal period as a result of genetically modified fibrylohenez extracellular matrix, leading to frustration on tissue homeostasis levels prohradiyentnym course. A clinical and neurological examination of 90 patients with an average age of 31,5 ± 13,5 g. оf vertebral syndrome, lumbosacral spine. The results of the clinical study demonstrated that patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0,05) more common intervertebral disc protrusion, more pronounced changes in yellow ties, in the form of thickening. Concomitant diseases (manifestations DST) scoliosis, kyphosis, kyphoscoliosis, hiperruhlyvist joints, tendency to dislocation, stretching ligaments joints - significantly (p <0,05) increase the duration of treatment and the severity of pain. Analysis of the survey data and monitoring of patients in the dynamics of the treatment showed that patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0,05) more likely to have anatomical changes in the lumbosacral spine, than in patients without evidence of DST.

scholarly journals Vertebrogenous syndrome, lumbosacral spine against the backdrop of connective tissue dysplasia in athletes

2016 ◽  
pp. 18-24
Author(s):  
A. Pyantkovsky
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Postnatal Period ◽  
Tissue Homeostasis ◽  
Lumbosacral Spine ◽  
Duration Of Treatment ◽  
Disc Protrusion ◽  
Anatomical Changes ◽  
Connective Tissue Dysplasia ◽  
Pain Analysis

In Ukraine, according to WHO, the disease of the spine is the fourth after cardiovascular system, oncology and pathology of diabetes. Dysplasia of connective tissue (DST) - a violation of the structure of the connective tissue in the embryonic and postnatal period as a result of genetically modified fibrylohenez extracellular matrix, leading to frustration on tissue homeostasis levels prohradiyentnym course. A clinical and neurological examination of 90 patients with an average age of 31,5 ± 13,5 g. оf vertebral syndrome, lumbosacral spine. The results of the clinical study demonstrated that patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0,05) more common intervertebral disc protrusion, more pronounced changes in yellow ties, in the form of thickening. Concomitant diseases (manifestations DST) scoliosis, kyphosis, kyphoscoliosis, hiperruhlyvist joints, tendency to dislocation, stretching ligaments joints - significantly (p <0,05) increase the duration of treatment and the severity of pain. Analysis of the survey data and monitoring of patients in the dynamics of the treatment showed that patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0,05) more likely to have anatomical changes in the lumbosacral spine, than in patients without evidence of DST.

scholarly journals Analysis of the frequency of connective tissue dysplasia

2016 ◽  
pp. 21-25
Author(s):  
A. Pyantkovsky
Keyword(s):  
Connective Tissue ◽  
High Probability ◽  
Tissue Homeostasis ◽  
Lumbosacral Spine ◽  
Neurological Manifestations ◽  
Duration Of Treatment ◽  
Connective Tissue Dysplasia ◽  
Data Screening ◽  
Progressive Course

In recent decades, increasing attention attracts practitioners role of pathology of different organs and systems of the human body associated with connective tissue dysplasia (DST). The significance of this problem is due to a large prevalence of GOST, system damage, high probability of the formation of different kinds of diseases. Dysplasia of connective tissue (display breach) a violation of the structure of the connective tissue in the embryonic and postnatal periods due to genetically modified extracellular matrix, leading to frustration on tissue homeostasis and organ levels with a progressive course. There have been clinical and neurological examination of 120 patients with neurological manifestations of the syndrome vertebrogenic lumbar spine. Analysis of the results of the clinical study demonstrated that in patients with vertebral syndrome, lumbosacral spine against the background displays GOST significantly (p <0.05) more common protrusion m / s disk changes are more pronounced yellow ties as its thickening. And also more common syndrome joints and vascular dystonia. Significantly (p <0.05) displays GOST (scoliosis, kyphosis, kyphoscoliosis, joints, tendency to dislocation, stretching the ligaments of the joints) - increases the duration of treatment and the severity of pain. The data screening and monitoring of patients in the dynamics of the treatment showed that patients with symptoms GOST significantly (p <0.05) more often aggravation vertebrogenic syndrome lumbosacral spine.

The Displays of Connective Tissue Dysplasia (Hypermobility) in Patients with Vertebral Syndrome of Lumbosacral Spine

2016 ◽  
pp. 149-154
Author(s):  
Oleksandr Piantkovskiy
Keyword(s):  
Connective Tissue ◽  
Varicose Veins ◽  
Pain Syndrome ◽  
Lumbosacral Spine ◽  
Duration Of Treatment ◽  
Medical Practitioners ◽  
Clinical Neurological Examination ◽  
Connective Tissue Dysplasia ◽  
Neurological Features

In recent years medical practitioners more often pay their attention on role of pathology of different organs and systems of human’s body which are associated with connective tissue dysplasia. The importance of this problem is caused by the great prevalence of connective tissue dysplasia, systemacity of damage, high probability of different diseases’ formation. Connective tissue dysplasia is the violation of the connective tissue structure during embryonic and postnatal periods because of genetically modified fibrillogenesis of extracellular matrix, leading to homeostasis disorder on tissue and organ levels with the progressive course. There was held the clinical neurological examination with 120 patients, who had neurological features of vertebral syndrome of lumbosacral spine. Analysis of the clinical examination results demonstrated that patients with vertebral syndrome of lumbosacral spine (p<0,05) more common can occur pathology of joints and varicose veins of the lower extremities. Significantly (p<0,05) (scoliosis, kyphosis, kyphoscoliosis, tendency to dislocation, stretching the ligaments) increase the duration of treatment and the expression of a pain syndrome. The results of examination and monitoring of patients in the dynamics of the treatment showed that patients with vertebral syndrome of lumbosacral spine (p<0,05) more often have anatomical changes in the lumbosacral spine than patients without evidence of DST.

scholarly journals Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

2020 ◽  
Author(s):  
Deborah Simpson ◽  
Howard Choi ◽  
Ding Wang ◽  
Mark Prescott ◽  
Andrew A. Pitsillides ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Extracellular Matrix ◽  
Connective Tissue ◽  
Protein Turnover ◽  
Tissue Homeostasis ◽  
Turnover Rates ◽  
Connective Tissues ◽  
Isotope Labelling ◽  
Tissue Integrity ◽  
Tissue Proteome

AbstractMaintenance of connective tissue integrity is fundamental to sustain function, requiring protein turnover to repair damaged tissue. However, connective tissue proteome dynamics remain largely undefined, as do differences in turnover rates of individual proteins in the collagen and glycoprotein phases of connective tissue extracellular matrix (ECM). Here, we investigate proteome dynamics in the collagen and glycoprotein phases of connective tissues by exploiting the spatially distinct fascicular (collagen-rich) and interfascicular (glycoprotein-rich) ECM phases of tendon. Using isotope labelling, mass spectrometry and bioinformatics, we calculate turnover rates of individual proteins within rat Achilles tendon and its ECM phases. Our results demonstrate complex proteome dynamics in tendon, with ~1000-fold differences in protein turnover rates, and overall faster protein turnover within the glycoprotein-rich interfascicular matrix compared to the collagen-rich fascicular matrix. These data provide insights into the complexity of proteome dynamics in tendon, likely required to maintain tissue homeostasis.

scholarly journals Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Howard Choi ◽  
Deborah Simpson ◽  
Ding Wang ◽  
Mark Prescott ◽  
Andrew A Pitsillides ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Extracellular Matrix ◽  
Connective Tissue ◽  
Protein Turnover ◽  
Tissue Homeostasis ◽  
Turnover Rates ◽  
Connective Tissues ◽  
Isotope Labelling ◽  
Tissue Integrity ◽  
Tissue Proteome

Maintenance of connective tissue integrity is fundamental to sustain function, requiring protein turnover to repair damaged tissue. However, connective tissue proteome dynamics remain largely undefined, as do differences in turnover rates of individual proteins in the collagen and glycoprotein phases of connective tissue extracellular matrix (ECM). Here, we investigate proteome dynamics in the collagen and glycoprotein phases of connective tissues by exploiting the spatially distinct fascicular (collagen-rich) and interfascicular (glycoprotein-rich) ECM phases of tendon. Using isotope labelling, mass spectrometry and bioinformatics, we calculate turnover rates of individual proteins within rat Achilles tendon and its ECM phases. Our results demonstrate complex proteome dynamics in tendon, with ~1000 fold differences in protein turnover rates, and overall faster protein turnover within the glycoprotein-rich interfascicular matrix compared to the collagen-rich fascicular matrix. These data provide insights into the complexity of proteome dynamics in tendon, likely required to maintain tissue homeostasis.

Metabolic therapy and its role in the complex treatment of connective tissue dysplasia in Pediatric Nephrology

2016 ◽  
Vol 73 (1) ◽  
pp. 131-136 ◽  
Author(s):  
S.L. Nyan'kovskyi ◽  
◽  
O.O. Dobrik ◽  
M.Yu. Іs'kiv ◽  
◽  
...  
Keyword(s):  
Connective Tissue ◽  
Pediatric Nephrology ◽  
Complex Treatment ◽  
Metabolic Therapy ◽  
Connective Tissue Dysplasia
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