scholarly journals A Combination of Short and Simple Surfactant Protein B and C Analogues as a New Synthetic Surfactant: In Vitro and Animal Experiments

2017 ◽  
Vol 58 (4) ◽  
pp. 823 ◽  
Author(s):  
Yong-Sung Choi ◽  
Sung-Hoon Chung ◽  
Chong-Woo Bae
Keyword(s):  
Animal Experiments ◽  
Surfactant Protein ◽  
Synthetic Surfactant ◽  
Surfactant Protein B ◽  
Protein B

Surfactant protein B labelled with [99mTc(CO)3(H2O)3]+ retains biological activity in vitro

2001 ◽  
Vol 28 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Anton Amann ◽  
Clemens Decristoforo ◽  
Ingo Ott ◽  
Martin Wenger ◽  
Dietmar Bader ◽  
...  
Keyword(s):  
Biological Activity ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Protein B

Disulphide Bridges in Surfactant Protein B Analogues Affect Their Activity in Synthetic Surfactant Preparations

Neonatology ◽  
2018 ◽  
Vol 115 (2) ◽  
pp. 134-141
Author(s):  
Oihana Basabe-Burgos ◽  
Jan Johansson ◽  
Tore Curstedt
Keyword(s):  
Surfactant Protein ◽  
Synthetic Surfactant ◽  
Surfactant Protein B ◽  
Protein B

scholarly journals Surface film formation in vitro by infant and therapeutic surfactants: role of surfactant protein B

2014 ◽  
Vol 77 (2) ◽  
pp. 340-346 ◽  
Author(s):  
Olivier Danhaive ◽  
Cheryl Chapin ◽  
Hart Horneman ◽  
Paola E. Cogo ◽  
Philip L. Ballard
Keyword(s):  
Film Formation ◽  
Surface Film ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Protein B

scholarly journals Allele-specific N-glycosylation delays human surfactant protein B secretion in vitro and associates with decreased protein levels in vivo

2013 ◽  
Vol 74 (6) ◽  
pp. 646-651 ◽  
Author(s):  
Saija Taponen ◽  
Johanna M. Huusko ◽  
Ulla E. Petäjä-Repo ◽  
Reija Paananen ◽  
Susan H. Guttentag ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Protein Levels ◽  
Surfactant Protein B ◽  
Allele Specific ◽  
Protein B

scholarly journals Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sandra Lawrynowicz Leibel ◽  
Alicia Winquist ◽  
Irene Tseu ◽  
Jinxia Wang ◽  
Daochun Luo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Human Lung ◽  
Induced Pluripotent Stem Cell ◽  
Surfactant Protein ◽  
Patient Specific ◽  
Surfactant Protein B ◽  
Induced Pluripotent ◽  
Protein B

Abstract Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants. Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. We alter the deficiency by infecting the SFTPB deficient iPSCs with a lentivirus carrying the wild type SFTPB gene. After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. We also show the presence of normal lamellar bodies and the secretion of surfactant into the cell culture medium in the organoids of lentiviral infected cells. These findings suggest that a lethal lung disease can be targeted and corrected in a human lung organoid model in vitro.

scholarly journals PPARɣ Agonist Pioglitazone and Synthetic Surfactant Protein B Mimic B‐YL Prevents Hyperoxia‐Induced Lung Injury in Adult Mice

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Chie Kurihara ◽  
Reiko Sakurai ◽  
Tsai‐Der Chuang ◽  
Alan Waring ◽  
Frans Walther ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Synthetic Surfactant ◽  
Adult Mice ◽  
Surfactant Protein B ◽  
Protein B

scholarly journals A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats

Neonatology ◽  
2018 ◽  
Vol 113 (4) ◽  
pp. 296-304 ◽  
Author(s):  
Reiko Sakurai ◽  
Cindy Lee ◽  
Humphrey Shen ◽  
Alan J. Waring ◽  
Frans J. Walther ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Synthetic Surfactant ◽  
Ppar Γ ◽  
Peptide Mimic ◽  
Surfactant Protein B ◽  
Neonatal Lung ◽  
Neonatal Lung Injury ◽  
Protein B
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