scholarly journals Additive-free selective methylation of amines with formic acid over a Pd/In2O3 catalyst

2021 ◽  
Author(s):  
Caroline Genre ◽  
Idir Benaissa ◽  
Timothé Godou ◽  
Mathieu Pinault ◽  
Thibault Cantat
Keyword(s):  
Formic Acid ◽  
Transfer Hydrogenation ◽  
Aliphatic Amines ◽  
Reaction Proceeds ◽  
Aromatic And Aliphatic Amines

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

scholarly journals Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst

2022 ◽  
Author(s):  
Caroline Genre ◽  
Idir Benaissa ◽  
Timothe Godou ◽  
Mathieu Pinault ◽  
Thibault Cantat
Keyword(s):  
Formic Acid ◽  
Transfer Hydrogenation ◽  
Aliphatic Amines ◽  
Secondary Amines ◽  
Reaction Proceeds ◽  
Aromatic And Aliphatic Amines

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over...

Versatile Rh- and Ir-Based Catalysts for CO2 Hydrogenation, Formic Acid Dehydrogenation, and Transfer Hydrogenation of Quinolines

2018 ◽  
Vol 57 (22) ◽  
pp. 14186-14198 ◽  
Author(s):  
Jairo Fidalgo ◽  
Margarita Ruiz-Castañeda ◽  
Gabriel García-Herbosa ◽  
Arancha Carbayo ◽  
Félix A. Jalón ◽  
...  
Keyword(s):  
Formic Acid ◽  
Co2 Hydrogenation ◽  
Transfer Hydrogenation ◽  
Formic Acid Dehydrogenation

Iron-Catalyzed One-pot Synthesis of Indole-tethered Tetrasubstituted Pyrroles and Their Transformations to Indolizino[8,7-b]indole Derivatives

Synthesis ◽  
2021 ◽  
Author(s):  
Xue Xiao ◽  
Xiao-Hui Chen ◽  
Xian-Xun Wang ◽  
Wan-Zhen Li ◽  
Hai-Lei Cui
Keyword(s):  
Aliphatic Amines ◽  
Electrophilic Cyclization ◽  
Indole Derivatives ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aromatic And Aliphatic Amines

We have developed an efficient iron-catalyzed one-pot reaction of tryptamines, ynones and nitroolefins affording indole-tethered tetrasubstituted pyrroles in acceptable to good yields. Other aromatic and aliphatic amines can also be utilized in this process delivering corresponding highly functionalized tetrasubstituted pyrroles. Indolizino[8,7-b]indole derivatives could be obtained through TFA, TfOH or Fe(OTf)3-mediated cyclizations via dearomatization of indole. Unexpected dibrominated products, 7,9-dibromo-6,11-dihydro-5H-indolizino[8,7-b]indoles, were formed when PTAP was employed as electrophilic cyclization promoter.

tert-Butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a green and chemoselective N-tert-butoxycarbonylation reagent

2019 ◽  
Vol 43 (17) ◽  
pp. 6549-6554
Author(s):  
Fangyu Du ◽  
Qifan Zhou ◽  
Yang Fu ◽  
Hanqi Zhao ◽  
Yuanguang Chen ◽  
...  
Keyword(s):  
Aliphatic Amines ◽  
Tert Butyl ◽  
Aromatic And Aliphatic Amines

The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2yl) carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated (30 examples).

Rhodium-catalyzed asymmetric transfer hydrogenation of 4-quinolone derivatives

2020 ◽  
Vol 7 (8) ◽  
pp. 975-979 ◽  
Author(s):  
Bin He ◽  
Phannarath Phansavath ◽  
Virginie Ratovelomanana-Vidal
Keyword(s):  
Formic Acid ◽  
Transfer Hydrogenation ◽  
Rhodium Complex ◽  
Asymmetric Transfer Hydrogenation ◽  
Quinolone Derivatives

4-Quinolone derivatives were conveniently reduced to 1,2,3,4-tetrahydroquinoline-4-ols with excellent enantioselectivities through asymmetric transfer hydrogenation using a tethered rhodium complex and formic acid/triethylamine as the hydride source.

scholarly journals N-Acetylation of Amines in Continuous-Flow with Acetonitrile—No Need for Hazardous and Toxic Carboxylic Acid Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1985 ◽  
Author(s):  
György Orsy ◽  
Ferenc Fülöp ◽  
István M. Mándity
Keyword(s):  
Carboxylic Acid ◽  
Continuous Flow ◽  
Scale Up ◽  
Drug Substance ◽  
Aliphatic Amines ◽  
Aromatic And Aliphatic Amines

A continuous-flow acetylation reaction was developed, applying cheap and safe reagent, acetonitrile as acetylation agent and alumina as catalyst. The method developed utilizes milder reagent than those used conventionally. The reaction was tested on various aromatic and aliphatic amines with good conversion. The catalyst showed excellent reusability and a scale-up was also carried out. Furthermore, a drug substance (paracetamol) was also synthesized with good conversion and yield.

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