scholarly journals Gut Microbiome-Mediated Alteration of Immunity, Inflammation, and Metabolism Involved in the Regulation of Non-alcoholic Fatty Liver Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Li-Hong He ◽  
Dun-Han Yao ◽  
Ling-Yun Wang ◽  
Lei Zhang ◽  
Xue-Li Bai
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Diagnosis And Treatment ◽  
Gastrointestinal Microbiome ◽  
Alcoholic Fatty Liver ◽  
Public Health Burden ◽  
Inflammatory Status ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of end-stage liver disease, leading to a rapidly growing global public health burden. The term “gut microbiome (GM)” refers to the approximately 100 trillion microbial cells that inhabit the host’s gastrointestinal tract. There is increasing evidence that GM is involved in the pathogenesis of NAFLD and may be a potential target for intervention. To explore GM-based strategies for precise diagnosis and treatment of NAFLD, great efforts have been made to develop a comprehensive and in-depth understanding of the host–microbe interaction. This review evaluates this interaction critically, mainly considering the intricate regulation of the metabolism, immunity, and inflammatory status during the evolution of the disease pathogenesis, revealing roles for the GM in NAFLD by examining advances in potential mechanisms, diagnostics, and modulation strategies.Synopsis: Considering the intricate metabolic and immune/inflammatory homeostasis regulation, we evaluate the latest understanding of the host–microbe interaction and reveal roles for the gastrointestinal microbiome in NAFLD. Strategies targeting the gastrointestinal microbiome for the diagnosis and treatment of NAFLD are proposed.

scholarly journals Pathogenesis, diagnosis and treatment of non-alcoholic fatty liver disease

2013 ◽  
Vol 105 (7) ◽  
pp. 409-420 ◽  
Author(s):  
Verónica Martín-Domínguez ◽  
Rosario González-Casas ◽  
Jorge Mendoza-Jiménez-Ridruejo ◽  
Luisa García-Buey ◽  
Ricardo Moreno-Otero
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diagnosis And Treatment ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Lactobacillus and Pediococcus ameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome

Gut Microbes ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 882-899 ◽  
Author(s):  
Na Young Lee ◽  
Sang Jun Yoon ◽  
Dae Hee Han ◽  
Haripriya Gupta ◽  
Gi Soo Youn ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Preventive effects of citrulline on Western diet-induced non-alcoholic fatty liver disease in rats

2016 ◽  
Vol 116 (2) ◽  
pp. 191-203 ◽  
Author(s):  
Prasanthi Jegatheesan ◽  
Stéphanie Beutheu ◽  
Kim Freese ◽  
Anne-Judith Waligora-Dupriet ◽  
Esther Nubret ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Steatosis ◽  
Western Diet ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Inflammatory Status ◽  
Liver Injuries ◽  
Alcoholic Fatty Liver Disease

AbstractA Western diet induces insulin resistance, liver steatosis (non-alcoholic fatty liver disease (NAFLD)) and intestinal dysbiosis, leading to increased gut permeability and bacterial translocation, thus contributing to the progression of NAFLD to non-alcoholic steatohepatitis. In the present study, we sought, in a model of Western diet-induced NAFLD, to determine whether citrulline (Cit), an amino acid that regulates protein and energy metabolism, could decrease Western diet-induced liver injuries, as well as the mechanisms involved. Sprague–Dawley rats were fed a high-fat diet (45 %) and fructose (30 %) in drinking water or a control diet associated with water (group C) for 8 weeks. The high-fat, high-fructose diet (Western diet) was fed either alone (group WD) or with Cit (1 g/kg per d) (group WDC) or an isonitrogenous amount of non-essential amino acids (group WDA). We evaluated nutritional and metabolic status, liver function, intestinal barrier function, gut microbiota and splanchnic inflammatory status. Cit led to a lower level of hepatic TAG restricted to microvesicular lipid droplets and to a lower mRNA expression of CCAAT-enhancer-binding protein homologous protein, a marker of endoplasmic reticulum stress, of pro-inflammatory cytokines Il6 (P<0·05) and Tnfα, and of toll-like receptor 4 (Tlr4) (P<0·05). Cit also improved plasma TAG and insulin levels. In the colon, it decreased inflammation (Tnfα and Tlr4 expressions) and increased claudin-1 protein expression. This was associated with higher levels of Bacteroides/Prevotella compared with rats fed the Western diet alone. Cit improves Western diet-induced liver injuries via decreased lipid deposition, increased insulin sensitivity, lower inflammatory process and preserved antioxidant status. This may be related in part to its protective effects at the gut level.

scholarly journals Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players?

2018 ◽  
Vol 1 ◽  
pp. 81-87 ◽  
Author(s):  
Valerio Nobili ◽  
Lorenza Putignani ◽  
Antonella Mosca ◽  
Federica Del Chierico ◽  
Pamela Vernocchi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Gut Microbiome and Metabolic response in Non-Alcoholic Fatty Liver Disease

2021 ◽  
Author(s):  
Asmita Madatali Abuwani ◽  
Shweta Priyadarshini Dash ◽  
Raja Ganesan ◽  
Kaviyarasi Renu ◽  
Vellingiri Balachandar ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Metabolic Response ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Estimation of Diagnosis and Treatment Costs of Non-Alcoholic Fatty Liver Disease: A Two-Year Observation

2013 ◽  
Vol 13 (5) ◽  
Author(s):  
Mohammad Ebrahim Ghamar Chehreh ◽  
Mohsen Vahedi ◽  
Mohammad Amin Pourhoseingholi ◽  
Sara Ashtari ◽  
Hossein Khedmat ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Treatment Costs ◽  
Diagnosis And Treatment ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Sex-Specific Associations between Gut Microbiome and Non-Alcoholic Fatty Liver Disease among Urban Chinese Adults

2021 ◽  
Vol 9 (10) ◽  
pp. 2118
Author(s):  
Jiajun Shi ◽  
Yaohua Yang ◽  
Wanghong Xu ◽  
Hui Cai ◽  
Jie Wu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Chinese Adults ◽  
Alcoholic Fatty Liver ◽  
Bifidobacterium Species ◽  
Α Diversity ◽  
History Of ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) has been linked to altered gut microbiome; however, evidence from large population-based studies is limited. We compared gut microbiome profiles of 188 male and 233 female NAFLD cases with 571 male and 567 female controls from two longitudinal studies of urban Chinese adults. History of NAFLD was assessed during surveys administered in 2004–2017. Microbiota were assessed using 16S rRNA sequencing of stool samples collected in 2015–2018. Associations of NAFLD with microbiome diversity and composition were evaluated by generalized linear or logistic regression models. Compared with controls, male cases had lower microbial α-diversity, higher abundance of genera Dialister and Streptococcus and Bifidobacterium species, lower abundance of genus Phascolarctobacterium, and lower prevalence of taxa including order RF39 (all p < 0.05). In contrast, female cases had higher α-diversity, higher abundance of genus Butyricimonas and a family of order Clostridiales, lower abundance of Dialister and Bifidobacterium species, and higher prevalence of RF39. Significant NAFLD–sex interactions were found for α-diversity and above taxa (all false discovery rate < 0.1). In conclusion, we observed sex-specific gut microbiome features related to history of NAFLD. Further studies are needed to validate our findings and evaluate the health effects of NAFLD-related gut microbiota.

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