scholarly journals No Association between Elevated Total Homocysteine Levels and Functional Outcome in Elderly Patients with Acute Cerebral Infarction

2017 ◽  
Vol 9 ◽  
Author(s):  
Wanjun Wang ◽  
Chunlin Gao ◽  
Changshen Yu ◽  
Shoufeng Liu ◽  
Dongzhe Hou ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Cerebral Infarction ◽  
Functional Outcome ◽  
Acute Cerebral Infarction ◽  
Total Homocysteine

scholarly journals Effect of Comprehensive Cerebral Protection Program on Cerebral Oxygen Metabolism and Vascular Endothelial Function in Elderly Patients with Acute Cerebral Infarction

2019 ◽  
Author(s):  
Meihong ZHOU ◽  
Zhaojun HUANG
Keyword(s):  
Elderly Patients ◽  
Cerebral Infarction ◽  
Endothelial Function ◽  
Oxygen Metabolism ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Cerebral Oxygen ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Cerebral Oxygen Metabolism

Background: We aimed to explore the effect of comprehensive cerebral protection on cerebral oxygen metabolism and vascular endothelial function in elderly patients with acute cerebral infarction. Methods: A total of 168 elderly patients with acute cerebral infarction treated in The First Affiliated Hospital of Nanchang University, China from January 2016 to January 2018 were selected. The patients were divided into a control group and an observation group using random number method, n=84. Patients in the observation group were given comprehensive cerebral protection treatment, and patients in the control group were treated with conventional standardized treatments. The changes of cerebral oxygen metabolism, hemorheology and vascular endothelial function before and after treatment were compared between the two groups. Results: After treatment, oxygen content in arteries and internal jugular veins (Da-vO2), ofoxygen uptake fraction (OEF), Oxygen saturation (SpO2), nitric oxide (NO) were increased in both groups in comparison to before treatment, jugular venous oxygen saturation (SjvO2), brain oxygen uptake rate (ERO2), endothelin (ET), intracranial pressure (ICP), whole blood viscosity, plasma viscosity, reduced viscosity of whole blood, and hematocrit were decreased. However, the changes in the observation group were larger than those in the control group, the difference was statistically significant (P<0.05). Conclusion: The treatment of cerebral infarction in elderly patients with acute cerebral infarction can effectively improve the cerebral oxygen metabolism and vascular endothelial function and improve the blood rheology, which has important clinical value.

Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction

2012 ◽  
Vol 224 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Jinkwon Kim ◽  
Dong Hyun Lee ◽  
Myoung-Jin Cha ◽  
Tae-Jin Song ◽  
Ji Hye Park ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Functional Outcome ◽  
Independent Predictor ◽  
Ankle Brachial Index ◽  
Acute Cerebral Infarction ◽  
Poor Functional Outcome

scholarly journals Symptomatic Steno-Occlusion in Patients with Acute Cerebral Infarction: Prevalence, Distribution, and Functional Outcome

2014 ◽  
Vol 16 (1) ◽  
pp. 36 ◽  
Author(s):  
Jihoon Kang ◽  
Tai Hwan Park ◽  
Kyung Bok Lee ◽  
Jong-Moo Park ◽  
Youngchai Ko ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Functional Outcome ◽  
Acute Cerebral Infarction

Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction

2012 ◽  
Vol 108 (08) ◽  
pp. 349-356 ◽  
Author(s):  
Jinkwon Kim ◽  
Young Kim ◽  
Tae-Jin Song ◽  
Ji Park ◽  
Hye Lee ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cerebral Infarction ◽  
Functional Outcome ◽  
Red Blood Cell ◽  
Stroke Onset ◽  
Acute Cerebral Infarction ◽  
Cell Distribution ◽  
Poor Functional Outcome ◽  
Distribution Width ◽  
Red Blood Cell Distribution

SummaryIncreased red blood cell distribution width (RDW), which is a marker of anisocytosis, is associated with mortality and cardiovascular events in the general population and in patients with heart failure or coronary heart disease. We investigated whether RDW in acute cerebral infarction is predictive of functional outcome and mortality. A total of 847 consecutive patients with first-ever acute cerebral infarction who presented to the emergency department within seven days of symptom onset were enrolled in this study. We investigated the association of RDW with poor functional outcome (modified Rankin Scale >2) and all-cause mortality at three months, as well as survival time for one year after stroke onset. Multivariate logistic regression revealed that higher RDW was independently associated with poor functional outcome (adjusted odds ratio [OR], 1.222 per 1% increment in RDW, 95% confidence interval [CI] 1.059–1.409, p=0.006) and all-cause death (adjusted OR, 1.395 per 1% increment in RDW, 95% CI 1.168–1.665, p<0.001) at three months after stroke onset. RDW was an independent predictor of survival in multivariate Cox-proportional regression model (adjusted hazard ratio, 1.328 per 1% increment in RDW, 95%CI 1.178–1.498, p<0.001). The addition of RDW to a survival model significantly increased predictability for survival across the entire follow-up period (weighted average of the area-under the curves, 0.858 vs. 0.841, p<0.05). In conclusion, higher RDW measured in cases of acute stage cerebral infarction was associated with poor functional outcome and mortality. RDW may be used as a biomarker for the prediction of long-term outcomes in patients with acute cerebral infarction.

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