scholarly journals Editorial: Advances in Spinal Cord Epidural Stimulation for Motor and Autonomic Functions Recovery After Severe Spinal Cord Injury

2022 ◽  
Vol 15 ◽  
Author(s):  
Enrico Rejc ◽  
Claudia A. Angeli ◽  
Ronaldo M. Ichiyama
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Autonomic Functions ◽  
Epidural Stimulation ◽  
Cord Injury

The effects of epidural stimulation on individuals living with spinal cord injury or disease: a scoping review

2021 ◽  
Vol 26 (5) ◽  
pp. 344-369
Author(s):  
Hope Jervis Rademeyer ◽  
Cindy Gauthier ◽  
Kei Masani ◽  
Maureen Pakosh ◽  
Kristin E. Musselman
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Scoping Review ◽  
Epidural Stimulation ◽  
Cord Injury

scholarly journals High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury

2017 ◽  
Vol 118 (4) ◽  
pp. 2344-2357 ◽  
Author(s):  
Elisa J. Gonzalez-Rothi ◽  
Kristi A. Streeter ◽  
Marie H. Hanna ◽  
Anna C. Stamas ◽  
Paul J. Reier ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
High Frequency ◽  
Muscle Activation ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Burst Frequency ◽  
Epidural Stimulation ◽  
Term Potentiation ◽  
Cord Injury

C2 spinal hemilesion (C2Hx) paralyzes the ipsilateral diaphragm, but recovery is possible through activation of “crossed spinal” synaptic inputs to ipsilateral phrenic motoneurons. We tested the hypothesis that high-frequency epidural stimulation (HF-ES) would potentiate ipsilateral phrenic output after subacute and chronic C2Hx. HF-ES (300 Hz) was applied to the ventrolateral C4 or T2 spinal cord ipsilateral to C2Hx in anesthetized and mechanically ventilated adult rats. Stimulus duration was 60 s, and currents ranged from 100 to 1,000 µA. Bilateral phrenic nerve activity and ipsilateral hypoglossal (XII) nerve activity were recorded before and after HF-ES. Higher T2 stimulus currents potentiated ipsilateral phasic inspiratory activity at both 2 and 12 wk post-C2Hx, whereas higher stimulus currents delivered at C4 potentiated ipsilateral phasic phrenic activity only at 12 wk ( P = 0.028). Meanwhile, tonic output in the ipsilateral phrenic nerve reached 500% of baseline values at the high currents with no difference between 2 and 12 wk. HF-ES did not trigger inspiratory burst-frequency changes. Similar responses occurred following T2 HF-ES. Increases in contralateral phrenic and XII nerve output were induced by C4 and T2 HF-ES at higher currents, but the relative magnitude of these changes was small compared with the ipsilateral phrenic response. We conclude that following incomplete cervical spinal cord injury, HF-ES of the ventrolateral midcervical or thoracic spinal cord can potentiate efferent phrenic motor output with little impact on inspiratory burst frequency. However, the substantial increases in tonic output indicate that the uninterrupted 60-s stimulation paradigm used is unlikely to be useful for respiratory muscle activation after spinal injury. NEW & NOTEWORTHY Previous studies reported that high-frequency epidural stimulation (HF-ES) activates the diaphragm following acute spinal transection. This study examined HF-ES and phrenic motor output following subacute and chronic incomplete cervical spinal cord injury. Short-term potentiation of phrenic bursting following HF-ES illustrates the potential for spinal stimulation to induce respiratory neuroplasticity. Increased tonic phrenic output indicates that alternatives to the continuous stimulation paradigm used in this study will be required for respiratory muscle activation after spinal cord injury.

scholarly journals Prolonged Targeted Cardiovascular Epidural Stimulation Improves Immunological Molecular Profile: A Case Report in Chronic Severe Spinal Cord Injury

2020 ◽  
Vol 14 ◽  
Author(s):  
Ona Bloom ◽  
Jill M. Wecht ◽  
Bonnie E. Legg Ditterline ◽  
Siqi Wang ◽  
Alexander V. Ovechkin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Molecular Profile ◽  
Epidural Stimulation ◽  
Cord Injury

Restoration of autonomic cardiovascular regulation in spinal cord injury with epidural stimulation: a case series

2020 ◽  
Author(s):  
Bonnie E. Legg Ditterline ◽  
Sevda C. Aslan ◽  
Siqi Wang ◽  
Beatrice Ugiliweneza ◽  
Glenn A. Hirsch ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Series ◽  
Cardiovascular Regulation ◽  
Epidural Stimulation ◽  
Cord Injury
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