scholarly journals Population Pharmacokinetics and Limited Sampling Strategy for Therapeutic Drug Monitoring of Polymyxin B in Chinese Patients With Multidrug-Resistant Gram-Negative Bacterial Infections

2020 ◽  
Vol 11 ◽  
Author(s):  
Peile Wang ◽  
Qiwen Zhang ◽  
Zhenfeng Zhu ◽  
Min Feng ◽  
Tongwen Sun ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Bacterial Infections ◽  
Sampling Strategy ◽  
Polymyxin B ◽  
Multidrug Resistant ◽  
Chinese Patients ◽  
Therapeutic Drug ◽  
Gram Negative ◽  
Limited Sampling

Limited Sampling Strategies for Therapeutic Drug Monitoring of Linezolid in Patients With Multidrug-Resistant Tuberculosis

2010 ◽  
Vol 32 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Jan-Willem C Alffenaar ◽  
Jos G W Kosterink ◽  
Richard van Altena ◽  
Tjip S van der Werf ◽  
Donald R A Uges ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Multidrug Resistant ◽  
Therapeutic Drug ◽  
Sampling Strategies ◽  
Resistant Tuberculosis ◽  
Limited Sampling ◽  
Multidrug Resistant Tuberculosis

Therapeutic drug monitoring of polymyxin B by LC–MS/MS in plasma and urine

Bioanalysis ◽  
2020 ◽  
Author(s):  
Xiaofen Liu ◽  
Zhenwei Yu ◽  
Yu Wang ◽  
Hailan Wu ◽  
Xingchen Bian ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Matrix Effect ◽  
Drug Monitoring ◽  
Solid Phase ◽  
Polymyxin B ◽  
Multidrug Resistant ◽  
Therapeutic Drug ◽  
Gram Negative Bacteria ◽  
The Matrix ◽  
Main Components

Background: A robust and rapid method for therapeutic drug monitoring (TDM) is urgently needed for polymyxin B, which is a last-line antibiotic for multidrug-resistant gram-negative bacteria infection. Methodology: A 3-min run of LC–MS/MS method was established to determine the main components of polymyxin B (polymyxin B1 and B2) in human plasma or urine. Solid-phase extraction was employed to eliminate the matrix effect from complicated samples from patients. Results: The calibration range was 0.050–5.00 and 0.0110–0.549 μg/ml for polymyxin B1 and B2, respectively, in plasma and urine. The precision and accuracy of quality controls, matrix effect, extraction recovery and stability were all validated and satisfied with the ICH requirements. The method was successfully applied to a pharmacokinetic study in healthy subjects and TDM in patients. Conclusion: The rapid LC–MS/MS method was validated for polymyxin B in plasma and urine, and robust for TDM.

scholarly journals Therapeutic Drug Monitoring of Protein Unbound Ciprofloxacin Concentrations to avoid inadequate Treatment of severe Bacterial Infections in Critically ill Patients

2018 ◽  
Vol 4 (5) ◽  
pp. 166-174
Author(s):  
Nora J mabelis ◽  
Kimberly N. Shudofsky ◽  
Joost J. van Raaij ◽  
Sjoerd D. Meenks ◽  
Thomas Havenith ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Critically Ill ◽  
Drug Monitoring ◽  
Critically Ill Patients ◽  
Bacterial Infections ◽  
Therapeutic Drug
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