scholarly journals Editorial: Involvement of Blood Brain Barrier Efficacy, Neurovascular Coupling and Angiogenesis in the Healthy and Diseased Brain

2021 ◽  
Vol 12 ◽  
Author(s):  
Daniela Carnevale ◽  
Fabrice Dabertrand ◽  
Clotilde Lecrux ◽  
Jean-Luc Morel
Keyword(s):  
Blood Brain Barrier ◽  
Neurovascular Coupling ◽  
Brain Barrier ◽  
Blood Brain

Seizure‐induced microvascular injury is associated with impaired neurovascular coupling and blood–brain barrier dysfunction

Epilepsia ◽  
2019 ◽  
Vol 60 (2) ◽  
pp. 322-336 ◽  
Author(s):  
Ofer Prager ◽  
Lyna Kamintsky ◽  
Luisa A. Hasam‐Henderson ◽  
Karl Schoknecht ◽  
Vera Wuntke ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Neurovascular Coupling ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Microvascular Injury ◽  
Blood Brain

Involvement of Blood Brain Barrier Efficacy, Neurovascular Coupling and Angiogenesis in the Healthy and Diseased Brain

2021 ◽  
Author(s):  
Jean-luc Morel ◽  
Daniela Carnevale ◽  
Fabrice Dabertrand ◽  
Clotilde Lecrux
Keyword(s):  
Blood Brain Barrier ◽  
Neurovascular Coupling ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Slice Cultures as a Model to Study Neurovascular Coupling and Blood Brain Barrier In Vitro

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Richard Kovács ◽  
Ismini Papageorgiou ◽  
Uwe Heinemann
Keyword(s):  
Blood Brain Barrier ◽  
Basal Lamina ◽  
Neurovascular Coupling ◽  
Brain Barrier ◽  
Tight Coupling ◽  
Blood Brain ◽  
Luminal Side ◽  
Calcein Am ◽  
Free Radical Formation

Proper neuronal functioning depends on a strictly regulated interstitial environment and tight coupling of neuronal and metabolic activity involving adequate vascular responses. These functions take place at the blood brain barrier (BBB) composed of endothelial cells, basal lamina covered with pericytes, and the endfeet of perivascular astrocytes. In conventional in vitro models of the BBB, some of these components are missing. Here we describe a new model system for studying BBB and neurovascular coupling by using confocal microscopy and fluorescence staining protocols in organotypic hippocampal slice cultures. An elaborated network of vessels is retained in culture in spite of the absence of blood flow. Application of calcein-AM either from the interstitial or from the luminal side resulted in different staining patterns indicating the maintenance of a barrier. By contrast, the ethidium derivative MitoSox penetrated perivascular basal lamina and revealed free radical formation in contractile cells embracing the vessels, likely pericytes.

scholarly journals Impaired neurovascular coupling to ictal epileptic activity and spreading depolarization in a patient with subarachnoid hemorrhage: Possible link to blood-brain barrier dysfunction

Epilepsia ◽  
2012 ◽  
Vol 53 ◽  
pp. 22-30 ◽  
Author(s):  
Maren K. L. Winkler ◽  
Yoash Chassidim ◽  
Svetlana Lublinsky ◽  
Gajanan S. Revankar ◽  
Sebastian Major ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Blood Brain Barrier ◽  
Neurovascular Coupling ◽  
Epileptic Activity ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Spreading Depolarization ◽  
Blood Brain

Neuronal regulation of the blood–brain barrier and neurovascular coupling

2020 ◽  
Vol 21 (8) ◽  
pp. 416-432 ◽  
Author(s):  
Luke Kaplan ◽  
Brian W. Chow ◽  
Chenghua Gu
Keyword(s):  
Blood Brain Barrier ◽  
Neurovascular Coupling ◽  
Brain Barrier ◽  
Blood Brain ◽  
Neuronal Regulation

Comparative in vivo and pathological analysis of the blood-brain barrier in mouse telencephalic transplants

1996 ◽  
Vol 22 (2) ◽  
pp. 118-128 ◽  
Author(s):  
S. Isenmann ◽  
S. Brandner ◽  
G. Kuhne ◽  
J. Boner ◽  
A. Aguzzi
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Pathological Analysis ◽  
Blood Brain

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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