Mindfulness-Based Cognitive Therapy for Unmedicated Obsessive-Compulsive Disorder: A Randomized Controlled Trial With 6-Month Follow-Up

Background: This was the first randomized controlled trial (RCT) designed to compare the efficacy of mindfulness-based cognitive therapy (MBCT) on unmedicated obsessive-compulsive disorder with that of the first-line treatment for OCD (SSRIs) or a placebo, as well as to analyze the treatment acceptability and safety of MBCT.Methods: A total of 123 unmedicated OCD patients with mild to moderate symptoms were randomly assigned into selective serotonin reuptake inhibitors group (SSRIs group), MBCT group or psycho-education group (PE group), respectively. They were intervened for 10 weeks. The Yale–Brown Obsessive-Compulsive Scale (Y-BOCS) grade was the primary outcome, and Hamilton Depression Scale-24 (HAMD-24) and Hamilton Anxiety Scale (HAMA) grades were secondary outcomes to be measured at baseline, mid-intervention, post-intervention and 14, 22, and 34 weeks of follow-up. The Five Facet Mindfulness Questionnaire (FFMQ) and Sheehan Disability Scale (SDS) were used to assess mindfulness and social functions, respectively. In addition, treatment acceptability (dropout rate and frequency of occurrence) and safety [adverse event (AE)] of MBCT were investigated.Results: Significant differences were detected in the treatment responses among SSRIs group, MBCT group and PE group. Notably, treatment responses were significantly better in the former two groups than that of PE group (χ2 = 6.448, p = 0.04), although we did not identify significant differences between SSRIs group and MBCT group (χ2 = 1.220, p = 0.543). Observed until 6 months of follow-up, there were no significant differences in treatment response among three groups. No AE was recorded in MBCT group.Conclusion: MBCT is effective in the treatment of unmedicated OCD with mild to moderate symptoms comparable to that of SSRIs, which contributes to maintain the treatment outcomes at follow-up. Besides, MBCT is safe with a good clinical compliance.

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A Randomized Controlled Trial of Cognitive Therapy versus Intensive Behavior Therapy in Obsessive Compulsive Disorder

Psychotherapy and Psychosomatics ◽

10.1159/000056269 ◽

2001 ◽

Vol 70 (6) ◽

pp. 288-297 ◽

Cited By ~ 136

Author(s):

Jean Cottraux ◽

Ivan Note ◽

Sai Nan Yao ◽

Sylviane Lafont ◽

Brigitte Note ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Therapy ◽

Obsessive Compulsive Disorder ◽

Behavior Therapy ◽

Controlled Trial ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Randomized Controlled

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Mindfulness-based cognitive therapy (MBCT) in patients with obsessive–compulsive disorder (OCD) and residual symptoms after cognitive behavioral therapy (CBT): a randomized controlled trial

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-018-0957-4 ◽

2018 ◽

Vol 269 (2) ◽

pp. 223-233 ◽

Cited By ~ 9

Author(s):

Anne Katrin Külz ◽

Sarah Landmann ◽

Barbara Cludius ◽

Nina Rose ◽

Thomas Heidenreich ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Behavioral Therapy ◽

Cognitive Therapy ◽

Obsessive Compulsive Disorder ◽

Behavioral Therapy ◽

Controlled Trial ◽

Obsessive Compulsive ◽

Residual Symptoms ◽

Compulsive Disorder ◽

Randomized Controlled

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Does Concentrated Exposure Treatment for Obsessive-Compulsive Disorder Improve Insomnia Symptoms? Results From a Randomized Controlled Trial

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.625631 ◽

2021 ◽

Vol 12 ◽

Author(s):

Kristen Hagen ◽

Håkon Nordahl ◽

Gunvor Launes ◽

Gerd Kvale ◽

Lars-Göran Öst ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Obsessive Compulsive Disorder ◽

Day Treatment ◽

Controlled Trial ◽

Obsessive Compulsive ◽

Exposure Treatment ◽

Compulsive Disorder ◽

Randomized Controlled ◽

Substantial Problem

Insomnia is a substantial problem in patients with obsessive-compulsive disorder (OCD). There is, however, a lack of studies investigating changes in concurrent symptoms of insomnia in OCD after concentrated treatment. A recent randomized controlled trial randomized participants to the Bergen 4-day treatment (B4DT, n = 16), or 12 weeks of unguided self-help (SH, n = 16), or waitlist (WL, n = 16). Patients from the SH- and WL-group who wanted further treatment after the 12 weeks were then offered the B4DT (total of 42 patients treated with the B4DT). There were no significant differences in symptoms of insomnia between the conditions at post-treatment, but a significant moderate improvement at 3-month follow-up for patients who received the B4DT. Insomnia was not associated with OCD-treatment outcome, and change in symptoms of insomnia was mainly related to changes in depressive symptoms. The main conclusion is that concentrated exposure treatment is effective irrespective of comorbid insomnia, and that insomnia problems are moderately reduced following treatment.

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P.0359 Mindfulness-based cognitive therapy: efficacy and fmri-based response predictors in obsessive-compulsive disorder: study protocol for a randomized controlled trial

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2021.10.340 ◽

2021 ◽

Vol 53 ◽

pp. S261-S262

Author(s):

N. Miquel Giner ◽

M. Vicent-Gil ◽

I. Martínez-Zalacaín ◽

D. Porta-Casteras ◽

L. Mar-Barrutia ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Therapy ◽

Obsessive Compulsive Disorder ◽

Study Protocol ◽

Controlled Trial ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Therapy Efficacy ◽

Randomized Controlled ◽

Response Predictors

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Assignment refusal and its relation to outcome in a randomized controlled trial comparing Cognitive Therapy and Fluvoxamine in treatment-resistant patients with obsessive compulsive disorder

Psychiatry Research ◽

10.1016/j.psychres.2014.12.050 ◽

2015 ◽

Vol 226 (1) ◽

pp. 198-203

Author(s):

Johannes A. Landsheer ◽

Johannes H. Smit ◽

Patricia van Oppen ◽

Anton J.L.M. van Balkom

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Therapy ◽

Obsessive Compulsive Disorder ◽

Controlled Trial ◽

Treatment Resistant ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Randomized Controlled

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A randomized controlled trial of mindfulness-based cognitive therapy vs stress management training for obsessive-compulsive disorder

Journal of Affective Disorders ◽

10.1016/j.jad.2020.12.082 ◽

2021 ◽

Vol 282 ◽

pp. 58-68

Author(s):

Sonal Mathur ◽

Mahendra P Sharma ◽

Srinivas Balachander ◽

Thennarasu Kandavel ◽

YC Janardhan Reddy

Keyword(s):

Randomized Controlled Trial ◽

Stress Management ◽

Cognitive Therapy ◽

Obsessive Compulsive Disorder ◽

Controlled Trial ◽

Management Training ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Stress Management Training ◽

Randomized Controlled

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Does the addition of cognitive therapy to exposure and response prevention for obsessive compulsive disorder enhance clinical efficacy? A randomized controlled trial in a community setting

British Journal of Clinical Psychology ◽

10.1111/bjc.12188 ◽

2018 ◽

Vol 58 (1) ◽

pp. 1-18 ◽

Cited By ~ 8

Author(s):

Neil A. Rector ◽

Margaret A. Richter ◽

Danielle Katz ◽

Michelle Leybman

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Therapy ◽

Obsessive Compulsive Disorder ◽

Clinical Efficacy ◽

Controlled Trial ◽

Community Setting ◽

Exposure And Response Prevention ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Randomized Controlled

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A Preliminary Examination of Acceptance and Commitment Therapy Versus Exposure and Response Prevention for Patients with Obsessive-Compulsive Disorder on an Optimal Dose of SSRIs: A Randomized Controlled Trial in Iran

Behavior Modification ◽

10.1177/0145445520982977 ◽

2020 ◽

pp. 014544552098297

Author(s):

Mehdi Zemestani ◽

Mojgan Salavati ◽

Asrin Seyedolshohadayi ◽

Julie M. Petersen ◽

Clarissa W. Ong ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Obsessive Compulsive Disorder ◽

Acceptance And Commitment Therapy ◽

Controlled Trial ◽

Exposure And Response Prevention ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Randomized Controlled ◽

Acceptance And Commitment

This study compared the effects of adding acceptance and commitment therapy (ACT) or exposure and response prevention (ERP) to adults diagnosed with obsessive compulsive disorder (OCD) already on an optimal and stable dose of selective serotonin reuptake inhibitors (SSRIs). Forty adults on SSRIs who were diagnosed with OCD participated in a randomized controlled trial in Iran of 12 individual weekly sessions of either ACT+SSRI, ERP+SSRI, or continued SSRI only. The results showed significant reductions in OCD symptom severity in ACT+SSRI and ERP+SSRI conditions at posttreatment with significantly greater reductions in both conditions compared to SSRI-only at follow-up. Additionally, psychological inflexibility and use of thought control strategies significantly decreased in the ACT+SSRI condition at posttreatment and follow-up compared to the ERP+SSRI and SSRI conditions. Both conditions led to decreases in perceived importance of stop signals. Results provide cross-cultural support for the treatment of OCD using ACT and ERP as adjuncts to SSRI and modest process of change differences between ACT and ERP. Future directions and study limitations are discussed.

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