Clinical Outcomes Following Single vs. Multiple Vessel Living-Donor Kidney Transplantation: A Retrospective Comparison of 210 Patients

Background: The use of living-donor kidney allografts with multiple vessels continues to rise in order to increase the donor pool. This requires surgeons to pursue vascular reconstructions more often, which has previously been associated with a higher risk of developing early post-transplant complications. We therefore wanted to investigate the prognostic role of using living-donor renal allografts with a single artery (SA) vs. multiple arteries (MA) at the time of transplant.Methods: We retrospectively analyzed a cohort of 210 consecutive living-donor kidney transplants performed between January, 2008 and March, 2019, and compared the incidence of developing postoperative complications and other clinical outcomes between SA vs. MA recipients.Results: No differences were observed between SA (N = 161) and MA (N = 49) kidneys in terms of the incidence of developing a postoperative (or surgical) complication, a urologic complication, hospital length of stay, delayed graft function, estimated glomerular filtration rate at 3 or 12 mo post-transplant, and graft survival.Conclusions: The use of live-kidney allografts with MA requiring vascular reconstruction shows excellent clinical outcomes and does not increase the risk of developing postoperative complications or other adverse outcomes when compared with SA renal allografts.

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Association Between Delayed Graft Function (DGF) Biomarkers and Long-term Outcomes After Living Donor Kidney Transplantation

Reviews on Recent Clinical Trials ◽

10.2174/1574887113666180522082930 ◽

2018 ◽

Vol 13 (4) ◽

pp. 312-318 ◽

Cited By ~ 1

Author(s):

Zahra Sahraei ◽

Mona Mehdizadeh ◽

Jamshid Salamzadeh ◽

Mohsen Nafar ◽

Azadeh Eshraghi

Keyword(s):

Kidney Transplantation ◽

Living Donor ◽

Graft Function ◽

Delayed Graft Function ◽

Long Term Outcomes ◽

Donor Kidney ◽

Living Donor Kidney Transplantation ◽

Donor Kidney Transplantation ◽

Living Donor Kidney

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Outcomes in Living Donor Kidney Transplantation: The Role of Donor’s Kidney Function

Kidney & Blood Pressure Research ◽

10.1159/000512177 ◽

2021 ◽

pp. 1-11

Author(s):

Massimo Torreggiani ◽

Ciro Esposito ◽

Elena Martinelli ◽

Thomas Jouve ◽

Antoine Chatrenet ◽

...

Keyword(s):

Kidney Transplant ◽

Kidney Function ◽

Living Donor ◽

Graft Function ◽

Kidney Graft ◽

Donor Kidney ◽

Transplant Center ◽

Function Correlation ◽

End Stage ◽

Living Donor Kidney

Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for end-stage kidney disease (ESKD). Guidelines identify different estimated glomerular filtration rate (eGFR) thresholds to determine the eligibility of donors. The aim of our study was to evaluate whether pretransplant donor eGFR was associated with kidney function in the recipient. Methods: We retrospectively studied LDKT recipients who received a kidney graft between September 1, 2005, and June 30, 2016 in the same transplant center in France and that had eGFR data available at 3, 12, 24, and 36 months posttransplant. Results: We studied 90 donor-recipient pairs. The average age at time of transplant was 51.47 ± 10.95 for donors and 43.04 ± 13.52 years for recipients. Donors’ average eGFR was 91.99 ± 15.37 mL/min/1.73 m2. Donor’s age and eGFR were significantly correlated (p < 0.0001, r2 0.023). Donor’s age and eGFR significantly correlated with recipient’s eGFR at 3, 12, and 24 months posttransplant (age: p < 0.001 at all intervals; eGFR p = 0.001, 0.003, and 0.016, respectively); at 36 months, only donor’s age significantly correlated with recipient’s eGFR. BMI, gender match, and year of kidney transplant did not correlate with graft function. In the multivariable analyses, donor’s eGFR and donor’s age were found to be associated with graft function; correlation with eGFR was lost at 36 months; and donor’s age retained a strong correlation with graft function at all intervals (p < 0.001). Conclusions: Donor’s eGFR and age are strong predictors of recipient’s kidney function at 3 years. We suggest that donor’s eGFR should be clinically balanced with other determinants of kidney function and in particular with age.

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