<b><i>Purpose:</i></b> This study aimed to analyze our data on delayed graft function (DGF) and to identify associated factors. <b><i>Methods:</i></b> This is a retrospective case-control study of all patients transplanted in our center over a period of 11 years (January 1, 2003, to December 31, 2014) comparing patients with immediate graft function (<i>n</i> = 332) to those with DGF (<i>n</i> = 165). DGF was defined as the need for hemodialysis within the first 7 days after transplantation. Donor and recipient characteristics as well as procedural factors were compared by univariate and multivariate logistic regression analyses. <b><i>Results:</i></b> Overall, 33% of patients had DGF. The rate of DGF declined from 2003 to 2011. In cases with DGF, donors and recipients were significantly older (<i>p</i> = 0.004 and <i>p</i> = 0.005, respectively), had longer cold ischemia times (<i>p</i> = 0.039), more revision surgeries (<i>p</i> < 0.001), and more HLA mismatches (<i>p</i> = 0.001), especially in the DR locus (<i>p</i> = 0.002). Neither donor nor recipient gender, waiting time, nor CMV status had any influence. In multivariable analysis, significant risk factors were ischemia time and mismatches at the HLA-DR loci. <b><i>Conclusions:</i></b> DGF is a common complication in renal transplantation which occurred in 33% of our cases. Important factors identified were donor and recipient age, ischemia time, HLA mismatching, and revision surgery.