scholarly journals Loss of Y-Chromosome during Male Breast Carcinogenesis

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 631 ◽  
Author(s):  
Marie Colombe Agahozo ◽  
Mieke A. M. Timmermans ◽  
Hein F. B. M. Sleddens ◽  
Renée Foekens ◽  
Anita M. A. C. Trapman-Jansen ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Carcinoma In Situ ◽  
Fluorescent In Situ Hybridization ◽  
Ductal Carcinoma ◽  
Male Breast ◽  
Early Event ◽  
Breast Carcinogenesis ◽  
Prognostic Effect ◽  
Number Of Patients

Loss of Y-chromosome (LOY) is associated with increased cancer mortality in males. The prevalence of LOY in male breast cancer (BC) is unknown. The aim of this study is to assess the presence and prognostic effect of LOY during male BC progression. We included male BC patients diagnosed between 1989 and 2009 (n = 796). A tissue microarray (TMA) was constructed to perform immunohistochemistry and fluorescent in situ hybridization (FISH), using an X and Y probe. We also performed this FISH on a selected number of patients using whole tissue slides to study LOY during progression from ductal carcinoma in situ (DCIS) to invasive BC. In total, LOY was present in 12.7% (n = 92) of cases, whereby LOY was associated with ER and PR negative tumors (p = 0.017 and p = 0.01). LOY was not associated with the outcome. Using whole slides including invasive BC and adjacent DCIS (n = 22), we detected a concordant LOY status between both components in 17 patients. In conclusion, LOY is an early event in male breast carcinogenesis, which generally starts at the DCIS stage and is associated with ER and PR negative tumors.

scholarly journals Pure Ductal Carcinoma in Situ in The Male Breast: A Rare Entity

2020 ◽  
Vol 16 (1) ◽  
pp. 77-80
Author(s):  
Saida Sakhri ◽  
◽  
Olfa Jaidane ◽  
Malek Bouhani ◽  
Olfa Adouni ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Male Breast ◽  
Rare Entity

Ductal carcinoma in situ of the male breast. Analysis of 31 cases

1997 ◽  
Vol 33 (1) ◽  
pp. 35-38 ◽  
Author(s):  
B. Cutuli ◽  
J.M. Dilhuydy ◽  
B. De Lafontan ◽  
J. Berlie ◽  
M. Lacroze ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Male Breast

scholarly journals Ductal carcinoma in situ of the male breast

Cancer ◽  
1994 ◽  
Vol 74 (4) ◽  
pp. 1289-1293 ◽  
Author(s):  
Mauricio G. Camus ◽  
Megha G. Joshi ◽  
Gasan Mackarem ◽  
Arthur K. C. Lee ◽  
Ricardo L. Rossi ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Male Breast

scholarly journals Is it necessary to remove intrapapillary ducts in therapeutic mammary adenectomies for breast cancer?

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Rebeca Neves Heinzen ◽  
Alfredo Carlos Simões Dornellas de Barros ◽  
Filomena Marino Carvalho ◽  
Cristiane da Costa Brandeia Abrahao Nimir ◽  
Alfredo Luiz Jacomo
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Glandular Tissue ◽  
Resonance Imaging ◽  
Areola Complex ◽  
Number Of Patients ◽  
Magnetic Resonance Imaging Mri

Introduction: The nipple-areola complex (NAC) has glandular tissue in intrapapillary ducts (IPDs). When the NAC is preserved during mammary adenectomies (MA) for the treatment of breast cancer (BC), this glandular tissue, which is a potential focus of tumor residues, remains. Objective: To estimate the frequency of neoplastic development in IPDs among BC patients treated with MA. Method: After the MA and with evidence of free retroareolar margin through intraoperative examination, the nipple was inverted, and its central portion, where mammary ducts are located, removed. A pointed-tip scalpel was used, preserving a tissue rim of 1.0 to 2.0 mm. The analysis involved 219 cases submitted to this type of surgery in the Clínica Professor Alfredo Barros. In all patients, the distance tumor-NAC was ≥2.0 cm, according to magnetic resonance imaging (MRI). The intrapapillary tissue removed was sent for microscopic examination of sections embedded in paraffin. Results: We found 4 cases of ductal carcinoma in situ (none infiltrating) in IPDs (1.19%). Considering only the 217 cases with free retroareolar margin in the definitive examination, the number of patients with ductal carcinoma in situ in IPDs decreased to 2 (0.9%). Conclusion: IPDs are rarely involved in selected cases of MA (distance tumor-NAC≥2.0 cm on MRI and free retroareolar margin). Ideally, they should be removed, especially when the intent is avoiding radiotherapy.

scholarly journals Expression of hypoxia-induced proteins in ductal carcinoma in situ and invasive cancer of the male breast

2019 ◽  
Vol 73 (4) ◽  
pp. 204-208 ◽  
Author(s):  
Marijn A Vermeulen ◽  
Carolien HM van Deurzen ◽  
Carolien P Schroder ◽  
John WM Martens ◽  
Paul J van Diest
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Invasive Cancer ◽  
Male Breast ◽  
Glucose Transporter 1 ◽  
Hypoxia Response ◽  
Glut 1 ◽  
Related Proteins

AimsThe aim of this study was to determine the role of hypoxia in male breast carcinogenesis by evaluating the expression of the hypoxia-related proteins, hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase IX (CAIX) and glucose transporter-1 (Glut-1), in ductal carcinoma in situ (DCIS) of the male breast in relation to invasive cancer (IC).MethodsTumour tissue blocks of 18 cases of pure DCIS, 58 DCIS cases adjacent to IC (DCIS-AIC) and the 58 IC cases were stained by immunohistochemistry for HIF-1α, CAIX and Glut-1, and expression frequencies and patterns (diffuse and/or perinecrotic) were noted.ResultsHIF-1α overexpression was observed in 61.1% (11/18) of pure DCIS, in 37.9% (22/58) of DCIS-AIC and in 36.2% (21/58) of IC cases (not significant (n.s.)). CAIX overexpression was observed in 16.7% (3/18) of pure DCIS, in 37.9% (22/58) of DCIS-AIC and in 24.1% (14/58) of IC cases (n.s.). Glut-1 overexpression was observed in 61.1% (11/18) of pure DCIS, in 75.9% (44/58) of DCIS-AIC and in 62.1% (36/58) of IC cases (n.s.). Expression of hypoxia-related proteins was seen around necrosis in a little over one-third of DCIS cases, and often coincided with expression in adjacent IC when present. All these observations indicate that the hypoxia response is already at its maximum in the preinvasive DCIS stage.ConclusionsIn conclusion, male DCIS frequently shows activated hypoxia response, comparable to male IC. This indicates that the activated hypoxia response previously seen in male IC is not a late bystander but likely a genuine carcinogenetic event.

1021 Ductal carcinoma in situ (DCIS) of the male breast: Analysis of 23 cases

1995 ◽  
Vol 31 ◽  
pp. S214
Author(s):  
B. Cutuli ◽  
M. Velten ◽  
M. Lacroze ◽  
F. Campana ◽  
J.M. Dilhuydy ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Male Breast

scholarly journals Synchronous bilateral ductal carcinoma in situ of the male breast associated with gynecomastia in a 30-year-old patient following repeated injections of stanozolol

2006 ◽  
Vol 97 (2) ◽  
pp. 177-177
Author(s):  
Ralph F. Staerkle ◽  
Philipp M. Lenzlinger ◽  
Stephan L. Suter ◽  
Zsuzsanna Varga ◽  
Gian A. Melcher
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Male Breast
Sign in / Sign up

Export Citation Format

Share Document