scholarly journals Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3

Data ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 33 ◽  
Author(s):  
Sheikh S. Abdullah ◽  
Neda Rostamzadeh ◽  
Kamran Sedig ◽  
Amit X. Garg ◽  
Eric McArthur

Medication-induced acute kidney injury (AKI) is a well-known problem in clinical medicine. This paper reports the first development of a visual analytics (VA) system that examines how different medications associate with AKI. In this paper, we introduce and describe VISA_M3R3, a VA system designed to assist healthcare researchers in identifying medications and medication combinations that associate with a higher risk of AKI using electronic medical records (EMRs). By integrating multiple regression models, frequent itemset mining, data visualization, and human-data interaction mechanisms, VISA_M3R3 allows users to explore complex relationships between medications and AKI in such a way that would be difficult or sometimes even impossible without the help of a VA system. Through an analysis of 595 medications using VISA_M3R3, we have identified 55 AKI-inducing medications, 24,212 frequent medication groups, and 78 medication groups that are associated with AKI. The purpose of this paper is to demonstrate the usefulness of VISA_M3R3 in the investigation of medication-induced AKI in particular and other clinical problems in general. Furthermore, this research highlights what needs to be considered in the future when designing VA systems that are intended to support gaining novel and deep insights into massive existing EMRs.

2021 ◽  
Vol 16 (2) ◽  
pp. 1-30
Author(s):  
Guangtao Wang ◽  
Gao Cong ◽  
Ying Zhang ◽  
Zhen Hai ◽  
Jieping Ye

The streams where multiple transactions are associated with the same key are prevalent in practice, e.g., a customer has multiple shopping records arriving at different time. Itemset frequency estimation on such streams is very challenging since sampling based methods, such as the popularly used reservoir sampling, cannot be used. In this article, we propose a novel k -Minimum Value (KMV) synopsis based method to estimate the frequency of itemsets over multi-transaction streams. First, we extract the KMV synopses for each item from the stream. Then, we propose a novel estimator to estimate the frequency of an itemset over the KMV synopses. Comparing to the existing estimator, our method is not only more accurate and efficient to calculate but also follows the downward-closure property. These properties enable the incorporation of our new estimator with existing frequent itemset mining (FIM) algorithm (e.g., FP-Growth) to mine frequent itemsets over multi-transaction streams. To demonstrate this, we implement a KMV synopsis based FIM algorithm by integrating our estimator into existing FIM algorithms, and we prove it is capable of guaranteeing the accuracy of FIM with a bounded size of KMV synopsis. Experimental results on massive streams show our estimator can significantly improve on the accuracy for both estimating itemset frequency and FIM compared to the existing estimators.


Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 450
Author(s):  
Gergely Honti ◽  
János Abonyi

Triplestores or resource description framework (RDF) stores are purpose-built databases used to organise, store and share data with context. Knowledge extraction from a large amount of interconnected data requires effective tools and methods to address the complexity and the underlying structure of semantic information. We propose a method that generates an interpretable multilayered network from an RDF database. The method utilises frequent itemset mining (FIM) of the subjects, predicates and the objects of the RDF data, and automatically extracts informative subsets of the database for the analysis. The results are used to form layers in an analysable multidimensional network. The methodology enables a consistent, transparent, multi-aspect-oriented knowledge extraction from the linked dataset. To demonstrate the usability and effectiveness of the methodology, we analyse how the science of sustainability and climate change are structured using the Microsoft Academic Knowledge Graph. In the case study, the FIM forms networks of disciplines to reveal the significant interdisciplinary science communities in sustainability and climate change. The constructed multilayer network then enables an analysis of the significant disciplines and interdisciplinary scientific areas. To demonstrate the proposed knowledge extraction process, we search for interdisciplinary science communities and then measure and rank their multidisciplinary effects. The analysis identifies discipline similarities, pinpointing the similarity between atmospheric science and meteorology as well as between geomorphology and oceanography. The results confirm that frequent itemset mining provides an informative sampled subsets of RDF databases which can be simultaneously analysed as layers of a multilayer network.


2017 ◽  
Vol 16 (06) ◽  
pp. 1549-1579 ◽  
Author(s):  
Jerry Chun-Wei Lin ◽  
Wensheng Gan ◽  
Philippe Fournier-Viger ◽  
Tzung-Pei Hong ◽  
Han-Chieh Chao

Frequent itemset mining (FIM) is a fundamental set of techniques used to discover useful and meaningful relationships between items in transaction databases. In recent decades, extensions of FIM such as weighted frequent itemset mining (WFIM) and frequent itemset mining in uncertain databases (UFIM) have been proposed. WFIM considers that items may have different weight/importance. It can thus discover itemsets that are more useful and meaningful by ignoring irrelevant itemsets with lower weights. UFIM takes into account that data collected in a real-life environment may often be inaccurate, imprecise, or incomplete. Recently, these two ideas have been combined in the HEWI-Uapriori algorithm. This latter considers both item weights and transaction uncertainty to mine the high expected weighted itemsets (HEWIs) using a two-phase Apriori-based approach. Although the upper-bound proposed in HEWI-Uapriori can reduce the size of the search space, it still generates a large amount of candidates and uses a level-wise search. In this paper, a more efficient algorithm named HEWI-Utree is developed to efficiently mine HEWIs without performing multiple database scans and without generating candidates. This algorithm relies on three novel structures named element (E)-table, weighted-probability (WP)-table and WP-tree to maintain the information required for identifying and pruning unpromising itemsets early. Experimental results show that the proposed algorithm is generally much more efficient than traditional methods for WFIM and UFIM, as well as the state-of-the-art HEWI-Uapriori algorithm, in terms of runtime, memory consumption, and scalability.


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