scholarly journals Clinical Significance of Tumor Size, Pathological Invasion Sites Including Urinary Collecting System and Clinically Detected Renal Vein Thrombus as Predictors for Recurrence in pT3a Localized Renal Cell Carcinoma

Diagnostics ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 154 ◽  
Author(s):  
Takuto Shimizu ◽  
Makito Miyake ◽  
Shunta Hori ◽  
Kota Iida ◽  
Kazuki Ichikawa ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Recurrence Rate ◽  
Tumor Size ◽  
Renal Cell ◽  
Renal Vein ◽  
Recurrence Rates ◽  
Renal Sinus ◽  
Collecting System ◽  
Urinary Collecting System

The recent eighth tumor-node-metastasis (TMN) staging system classifies renal cell carcinoma (RCC) with perirenal fat invasion (PFI), renal sinus fat invasion (SFI), or renal vein invasion (RVI) as stage pT3a. However, limited data are available on whether these sites have similar prognostic value or recurrence rate. We investigated the recurrence rate based on tumor size, pathological invasion sites including urinary collecting system invasion (UCSI), and clinically detected renal vein thrombus (cd-RVT) with pT3aN0M0 RCC. We retrospectively reviewed 91 patients with pT3aN0M0 RCC who underwent surgical treatment. Patients with tumor size > 7 cm, UCSI, three invasive sites (PFI + SFI + RVI), and cd-RVT showed a significant correlation with high recurrence rates (hazard ration (HR) 2.98, p = 0.013; HR 8.86, p < 0.0001; HR 14.28, p = 0.0008; and HR 4.08, p = 0.0074, respectively). In the multivariate analysis, tumor size of >7 cm, the presence of UCSI, and cd-RVT were the independent predictors of recurrence (HR 3.39, p = 0.043, HR 7.31, p = 0.01, HR 5.06, p = 0.018, respectively). In pT3a RCC, tumor size (7 cm cut-off), UCSI, and cd-RVT may help to provide an early diagnosis of recurrence.

Renal Cell Carcinoma Invading the Urinary Collecting System: Implications for Staging

2002 ◽  
pp. 2392-2396 ◽  
Author(s):  
ROBERT G. UZZO ◽  
EDWARD E. CHERULLO ◽  
JONATHAN MYLES ◽  
ANDREW C. NOVICK
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Collecting System ◽  
Urinary Collecting System

PROGNOSTIC VALUE OF URINARY COLLECTING SYSTEM INVASION IN RENAL CELL CARCINOMA

2006 ◽  
Vol 5 (2) ◽  
pp. 67 ◽  
Author(s):  
J.J. Patard ◽  
N. Rioux-leclercq ◽  
L. Cindolo ◽  
V. Ficarra ◽  
K. Bensalah ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Collecting System ◽  
Urinary Collecting System

scholarly journals MP78-02 URINARY COLLECTING SYSTEM INVASION IS ASSOCIATED WITH POOR SURVIVAL IN CLEAR CELL RENAL CELL CARCINOMA PATIENTS

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
George Bailey ◽  
Stephen Boorjian ◽  
Matthew Ziegelmann ◽  
Mary Westerman ◽  
Christine Lohse ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Poor Survival ◽  
Cell Renal Cell Carcinoma ◽  
Collecting System ◽  
Urinary Collecting System

Urinary collecting system invasion in renal cell carcinoma: Incidence and long-term prognosis

2009 ◽  
Vol 16 (9) ◽  
pp. 718-722 ◽  
Author(s):  
Andres Jan Schrader ◽  
Julia Rustemeier ◽  
Zoltan Varga ◽  
Axel Hegele ◽  
Peter Jochen Olbert ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Long Term Prognosis ◽  
Collecting System ◽  
Urinary Collecting System

1290: Prognostic Value of the Urinary Collecting System Invasion in Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 425-425
Author(s):  
Gregory Verhoest ◽  
Nathalie Rioux-Leclercq ◽  
Karim Bensalah ◽  
Francois Guille ◽  
Vincenzo Ficarra ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Collecting System ◽  
Urinary Collecting System

Prognostic Value of the Involvement of the Urinary Collecting System in Renal Cell Carcinoma

2004 ◽  
Vol 46 (4) ◽  
pp. 472-476 ◽  
Author(s):  
C. Terrone ◽  
C. Cracco ◽  
S. Guercio ◽  
E. Bollito ◽  
M. Poggio ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Collecting System ◽  
Urinary Collecting System

scholarly journals Renal Cell Carcinoma Intravascular Spread Into Segmental Branches of the Renal Vein: A Single Institution Case Series

2021 ◽  
Author(s):  
Mauro Giuseppe Mastropasqua ◽  
Marta Mariano ◽  
Federico Fusco ◽  
Gerardo Cazzato ◽  
Valentina Ruggiero ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Vein ◽  
Case Series ◽  
Venous Invasion ◽  
Accurate Method ◽  
Renal Sinus ◽  
Accurate Procedure ◽  
The Impact

(1) Background: Overall survival of the patients with renal cell carcinoma (RCC) depends mostly on extra-renal extension, documented by the invasion of the pelvicalyceal system, or the perinephric/renal sinus fat or the renal vein/its segmental intraparenchymal branches. Staging may be challenging because of the high inter-observer variability. We have introduced a more accurate procedure to detect the extra-renal extension and, to possibly evaluate the impact of such more laborious approach, we have compared the RCC pathological staging obtained following both standard and modified procedures; (2) Methods: We selected 54 consecutive cases of RCC diagnosed 18 months before and 54 consecutive cases diagnosed 18 months after the introduction of the new method of sampling. Clinico-pathological characteristics have been statistically analyzed; (3) Results: Most of the features analyzed were non statistically significative, except the extra-renal invasion. More precisely, the occurrence of retrograde venous invasion was higher in the cases grossly approached with the more accurate method; (4) Conclusions: Extra-renal extension to intraparenchymal renal vein branches may be underestimated, leading to an inappropriate under-staging. Using more accurate staging procedures, to disclose the occurrence of intra-renal veins tumoral thrombosis, helps to better define the pathological stage, allowing patients to benefit of better fitting treatments.

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