scholarly journals Stability of OCT and OCTA in the Intensive Therapy Unit Setting

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1516
Author(s):  
Ella F. Courtie ◽  
Aditya U. Kale ◽  
Benjamin T. K. Hui ◽  
Xiaoxuan Liu ◽  
Nicholas I. Capewell ◽  
...  

To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure and blood flow measurements by portable OCT and OCTA in the eye clinic and intensive therapy unit (ITU) across three timepoints: (1) pre-operation in a clinic setting; (2) 24–48 h post-operation during ITU admission; and (3) seven days post-operation, if the patient was still admitted. Blood flow and macular structural measures were stable between the examination settings, with no consistent variation between pre- and post-operation scans, while retinal nerve fibre layer thickness increased in the post-operative scans (+2.31 µm, p = 0.001). Foveal avascular zone (FAZ) measurements were the most stable, with an intraclass correlation coefficient of up to 0.92 for right eye FAZ area. Blood flow and structural measures were lower in left eyes than right eyes. Retinal blood flow assessed in patients before and during an ITU stay using portable OCTA showed no systematic differences between the clinical settings. The stability of retinal blood flow measures suggests the potential for portable OCTA to provide clinically useful measures in ITU patients.

2012 ◽  
Vol 43 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Ranjith K. Konduru ◽  
Ou Tan ◽  
Muneeswar G. Nittala ◽  
David Huang ◽  
Srinivas R. Sadda

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kyoung-A Cho ◽  
Abhishek Rege ◽  
Yici Jing ◽  
Akash Chaurasia ◽  
Amit Guruprasad ◽  
...  

AbstractRetinal blood flow (RBF) information has the potential to offer insight into ophthalmic health and disease that is complementary to traditional anatomical biomarkers as well as to retinal perfusion information provided by fluorescence or optical coherence tomography angiography (OCT-A). The present study was performed to test the functional attributes and performance of the XyCAM RI, a non-invasive imager that obtains and assesses RBF information. The XyCAM RI was installed and used in two different settings to obtain video recordings of the blood flow in the optic nerve head region in eyes of healthy subjects. The mean blood flow velocity index (BFVi) in the optic disc and in each of multiple arterial and venous segments was obtained and shown to reveal a temporal waveform with a peak and trough that correlates with a cardiac cycle as revealed by a reference pulse oximeter (correlation between respective peak-to-peak distances was 0.977). The intra-session repeatability of the XyCAM RI was high with a coefficient of variation (CV) of 1.84 ± 1.13% across both sites. Artery-vein comparisons were made by estimating, in a pair of adjacent arterial and venous segments, various temporal waveform metrics such as pulsatility index, percent time in systole and diastole, and change in vascular blood volume over a cardiac cycle. All arterial metrics were shown to have significant differences with venous metrics (p < 0.001). The XyCAM RI, therefore, by obtaining repeatable blood flow measurements with high temporal resolution, permits the differential assessment of arterial and venous blood flow patterns in the retina that may facilitate research into disease pathophysiology and biomarker development for diagnostics.


1980 ◽  
Author(s):  
K. Gardner ◽  
E. R. Pike ◽  
J. A. Govan ◽  
D. W. Hill

2020 ◽  
Vol 9 (7) ◽  
pp. 34 ◽  
Author(s):  
Stephan Szegedi ◽  
Nikolaus Hommer ◽  
Martin Kallab ◽  
Stefan Puchner ◽  
Doreen Schmidl ◽  
...  

2007 ◽  
Author(s):  
Stefano Cattini ◽  
Giorgia Salvatori ◽  
Luigi Rovati

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