scholarly journals Prenatal Diagnosis of Clubfoot: Where Are We Now? Systematic Review and Meta-Analysis

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2235
Author(s):  
Laura Ruzzini ◽  
Sergio De De Salvatore ◽  
Umile Giuseppe Longo ◽  
Martina Marino ◽  
Alessandra Greco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prenatal Diagnosis ◽  
Meta Analysis ◽  
Screening Method ◽  
Congenital Clubfoot ◽  
International Consensus ◽  
Primary Methods ◽  
The Us ◽  
Magnetic Resonance Imaging Mri

The primary methods for prenatal diagnosis of Clubfoot are ultrasound (US) and magnetic resonance imaging (MRI). An ultrasound is performed between the 1st trimester and the 28th week of pregnancy and it is reported to be used as a diagnostic method alone or in combination with MRI. So far, an international consensus on the most effective screening method has not been reached. This systematic review and meta-analysis were performed to establish the most effective and reliable exam for prenatal diagnosis of Clubfoot. The literature search was conducted using a PIOS-approach from May 2021 to June 2021. Studies reporting cases of prenatal diagnosis of Clubfoot made through US and MRI conducted from January 2010 to June 2021 were included in the study and reviewed by 2 authors. The 23 selected studies included 2318 patients. A total of 11 of the studies included details on the accuracy, while the rest were used to obtain information about the primary methodology utilized. In all the selected studies, US was used as the primary diagnostic instrument. Thirteen of the studies used the US exclusively, while three used MRI in addition to US and seven performed karyotyping after US diagnosis. The US has been shown to be the instrument of choice for the prenatal diagnosis of Clubfoot. International guidelines for an ultrasonography classification of congenital clubfoot are required to reduce the inter-variability accuracy of this procedure.

scholarly journals Estimating the Prevalence of HIV and Sexual Behaviors Among the US Transgender Population: A Systematic Review and Meta-Analysis, 2006–2017

2019 ◽  
Vol 109 (1) ◽  
pp. e1-e8 ◽  
Author(s):  
Jeffrey S. Becasen ◽  
Christa L. Denard ◽  
Mary M. Mullins ◽  
Darrel H. Higa ◽  
Theresa Ann Sipe
Keyword(s):  
Systematic Review ◽  
Sexual Behaviors ◽  
Meta Analysis ◽  
The Us

scholarly journals Application of Three Dimensional Geometric Morphometric Analysis for Sexual Dimorphism of Human Skull: A Systematic Review

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Abdelnasser Ibrahim ◽  
Aspalilah Alias ◽  
Mohamed Swarhib Shafie ◽  
Faridah Mohd Nor
Keyword(s):  
Systematic Review ◽  
Sexual Dimorphism ◽  
Morphometric Analysis ◽  
Meta Analysis ◽  
Positive Contribution ◽  
Inclusion Criteria ◽  
Geometric Morphometric ◽  
Human Skull ◽  
Geometric Morphometric Analysis

The present systematic review explores the most sexually dimorphic parameters by using geometric morphometric analysis of human skull. An extended search was conducted in Google Scholars and PubMed (published between 2005 and 2017). The main inclusion criteria were research articles published in English, and studies that used geometric morphometric analysis for classification of human skull. The literature search identified 54 potential relevant articles whereby, five had met the inclusion criteria. Most studies reported positive contribution of geometric morphometric as an alternative and accurate tool for classification of unknown human crania. Geometric morphometric method resulted in a high classification accuracy of sexual dimorphism among different populations. Further studies are required to approach the best method used for varied types of postcranial bones equipped with a more advanced meta-analysis of the results.

scholarly journals Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xudong Wang ◽  
Yangke Yu ◽  
Ningning Yang ◽  
Lei Xia
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Tethered Cord ◽  
Congenital Scoliosis ◽  
Cochrane Library ◽  
Resonance Imaging ◽  
R Software ◽  
Dural Ectasia ◽  
Magnetic Resonance Imaging Mri

Abstract Objective This is the first systematic review and meta-analysis on the overall incidence of intraspinal abnormalities in patients with congenital scoliosis (CS) and potential influencing factors. Methods We searched three large electronic databases (PubMed, EMBASE, and Cochrane Library) for potentially relevant studies. The quality of the included studies was assessed independently by two authors using the Methodological Index for Non-Randomized Studies (MINORS) criteria. Data on the number of CS patients, number of CS patients with intraspinal abnormalities, sex of the patients, and CS types were extracted from the included studies. R software was used to pool and analyze all the extracted data. Results This meta-analysis included 10 articles, and 671 of 1863 CS patients undergoing magnetic resonance imaging (MRI) examinations were identified to have intraspinal abnormalities. The overall incidence of intraspinal abnormalities in the patients with CS was 37% (95% CI, 29–45%). Diastematomyelia was the most common intraspinal abnormality and was detected in 45.60% of the patients with intraspinal abnormalities (306/671). The remaining intraspinal abnormalities included syringomyelia (273/671, 40.69%), tethered cord (190/671, 28.32%), low conus (58/671, 8.64%), intraspinal mass (39/671, 5.81%), Chiari malformation (32/671, 4.77%), fatty filum (27/671, 4.02%), spina bifida (occulta excluded) (17/671, 2.53%), tumor (17/671, 2.53%), cyst (12/671, 1.79%), syringomyelus (4/671, 0.60%), dural ectasia (1/671, 0.15%), and undiagnosed cord MRI hyperintensity (1/671, 0.15%). The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients (all P > 0.05). Conclusions This meta-analysis revealed that the overall incidence of intraspinal abnormalities detected by MRI in CS patients was 37%. Diastematomyelia was the most common intraspinal abnormality. The patient’s sex and CS type were not factors that affected the incidence of intraspinal abnormalities in CS patients.

scholarly journals Association of HLA-B*5701 Genotypes and Abacavir-Induced Hypersensitivity Reaction: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 18 (1) ◽  
pp. 68 ◽  
Author(s):  
Wimonchat Tangamornsuksan ◽  
Ornrat Lohitnavy ◽  
Chuenjid Kongkaew ◽  
Nathorn Chaiyakunapruk ◽  
Brad Reisfeld ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hypersensitivity Reaction ◽  
Diagnostic Criteria ◽  
Random Effects ◽  
Meta Analysis ◽  
Random Effects Model ◽  
Analysis Technique ◽  
The Us ◽  
Us Fda ◽  
Immunologic Test

OBJECTIVES: This study aimed to systematically review and quantitatively synthesize the association between HLA-B*5701 and abacavir-induced hypersensitivity reaction (ABC-HSR). METHODS: We searched for studies that investigated the association between HLA-B genotype and ABC-HSR and provided information about the frequency of carriers of HLA-B genotypes among cases and controls. We then performed a meta-analysis with a random-effects model to pool the data and to investigate the sources of heterogeneity. RESULTS: From 1,026 articles identified, ten studies were included. Five using clinical manifestation as their diagnostic criteria, 409 and 1,883 subjects were included as cases and controls. Overall OR was 23.6 (95% CI = 15.4 – 36.3). Whereas, the another five studies using confirmed immunologic test as their diagnostic criteria, 110 and 1,968 subjects were included as cases and controls, respectively. The association of ABC-HSR was strong in this populations with HLA-B*5701. Overall OR was 1,056.2 (95% CI = 345.0 – 3,233.3). CONCLUSIONS: Using meta-analysis technique, the association between HLA-B*5701 and ABC-HSR is strong in the studies using immunologic confirmation to identify ABC-HSR. These results support the US FDA recommendations for screening HLA-B*5701 allele before initiating abacavir therapy.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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