scholarly journals Molecular <em>docking </em>study of iclaprim derivatives with potential antineoplastic activity

2021 ◽  
Author(s):  
Marina Mijajlović ◽  
Teodora Tanasković ◽  
Miloš Nikolić ◽  
Nikola Nedeljković ◽  
Ana Stanković ◽  
...  
Keyword(s):  
Antineoplastic Activity

Combined Bcl-2/Bcl-xL and RAC1 inhibition yields a synergistic antineoplastic activity in glioblastoma

2018 ◽  
Author(s):  
M Hlavac ◽  
A Dwucet ◽  
A Westhoff ◽  
RE Kast ◽  
J Engelke ◽  
...  
Keyword(s):  
Antineoplastic Activity

Some 2-substitution derivatives of 5-(4-oxo-6-hydroxy-3,4-dihydro-5-pyrimidinyl)pentanoic acid

1983 ◽  
Vol 48 (1) ◽  
pp. 304-311 ◽  
Author(s):  
Jiří Křepelka ◽  
Jan Beneš ◽  
Vladimír Pouzar ◽  
Jaroslav Vachek ◽  
Jiří Holubek
Keyword(s):  
Nitrile Group ◽  
Antineoplastic Activity ◽  
Carboxyl Group ◽  
Positional Isomers ◽  
Pentanoic Acid ◽  
Pharmacological Tests ◽  
Derivatives Of

Condensation of triethyl ester of 1,1,5-pentanetricarboxylic acid (XI) with substituted guanidines XXII - XXIX gave acids II - IX, which were converted into esters XI - XIX. The acid II and the ester XI were obtained as mixtures of positional isomers. Analogously, condensation of the triester XXI with dicyanodiamide gave rise to acid X, whose nitrile group, under conditions of esterification of a carboxyl group, produced iminoether XX. In pharmacological tests for antineoplastic activity the compounds prepared exhibited weaker efficacy than 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid (I), employed as standard.

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